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| 1 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 2 | Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy显示文摘AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen. | István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth | 2013 | World Journal of Gastroenterology2013，19，6： | 2 |
| 3 | Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis显示文摘 | READ R W SZALAI A J VOGT S D | 2006 | Exp Eye Res2006，82，3： | 1 |
| 4 | Apoptosis driven by IP3 -linked mitochondrial calcium signals显示文摘 | Szalai G Kriahnamurthy R Hajnoczky G | 1999 | EMBO J1999，18，22： | 1 |
| 5 | Apoptosis driven by IP3-linked mitochondrial calcium signals显示文摘 | Szalai G Krishnamurthy R and Hajnóczky G | 1999 | EMBO J1999，18，： | 1 |
| 6 | Transplantation of human mesen- chymal stem cells in a non - autogenous setting for bone regeneration in a rabbit critical -size defect model 显示文摘 | Niemeyer P Szalay K Luginbuhl R | 2010 | Acta Biomater2010，6，3： | 1 |
| 7 | Delay, parametric excitation, and the nonlinear dynamics of cutting processes 显示文摘 | Stepan G Insperger T Szalai R | 2005 | International Journal of Bifurcation and Chaos2005，15，9： | 1 |
| 8 | Characterization of a leaf rust-resistant wheat–Thinopyrum ponticum partial amphiploid BE-1, using sequential multicolor GISH and FISH显示文摘 | A. Sepsi I. Molnár D. Szalay M. Molnár-Láng | 2008 | Theoretical and Applied Genetics2008，，6： | 1 |
| 9 | Transplantationof human mesenchymal stem cells in a non-autogenoussetting for bone regeneration in a rabbit critical-size defectmodel显示文摘 | Niemeyer P Szalay K Luginbuhl R | 2010 | Acta Biomater2010，6，3： | 1 |
| 10 | Nonlinear Dynamics of High-speed Milling-analyses,Numerics,and Experiments显示文摘 | Stepan G Szalai R Mann B P | 2005 | ASME Journal of Vibration and Acoustics2005，127，2： | 1 |
| 11 | apoptesis driven by IP(3)-linded mitochondrial calcium signals显示文摘 | Szalai G Krishnamurthy R Hajnoczky G | 1999 | EMBO J1999，1，8： | 1 |
| 12 | Differential scanning calorimetry (DSC) of blood serum in chronic obstructive pulmonary disease (COPD): A new diagnostic tool ahead?显示文摘 | Szalai Z Moln~ r TF Lorinczy D | 2013 | Journal of thermal analysis and calorimetry2013，113，1： | 1 |
| 13 | Apoptosis driven by IP3-linked mitochondrial calcium sgnals显示文摘 | Szalai G Krishnamurthy R Hajnoczky G | 1999 | EMBO J1999，18，22： | 1 |
| 14 | The chaotic oscillations of high -speed milling 显示文摘 | Stepan G Szalai R Hogan S J | 2003 | IUTAM Symposium on Chaotic Dynamics and Control of Systems and Processes in Mechanics2003，，6： | 1 |
| 15 | Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein e*3-leiden transgenic mice显示文摘 | Verschuren L Kleemann R Offerman EH Szalai AJ Emeis SJ Princen HM | 2005 | Arterioscler Thromb2005，25，： | 1 |
| 16 | Global Dynamics of Low Immersion High-speed Milling显示文摘 | SZALAI R ST(E)P(A)N G HOGAN S J | 2004 | Chaos2004，14，4： | 1 |
| 17 | Nestin modulates glueocorticoid receptor function by cytoplasmic anchoring显示文摘 | REIMER R HELMBOLD H SZALAY B | 2009 | PLoS One2009，4，6： | 1 |
| 18 | Human C-Reactive Protein is protective againstfatal Salmonella enterica Serovar Typhimurium infection in transgenic mice显示文摘 | Szalai A J Vancott J L McGhee J R | 2000 | Infection andImmunity2000，68，10： | 1 |
| 19 | In creased thrombosis after arterial injury in human C-reactive pro- tein-transgenicmice 显示文摘 | Danenberg H D Szalai A J Swaminathan R V | 2003 | Circulation2003，108，5： | 1 |
| 20 | Detection of attomole quantitites of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation 显示文摘 | GORE M R SZALAI V A ROPP P A | 2003 | Anal Chem2003，75，： | 1 |
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