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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Neovascularization of ischemic myocardium by human bone marrow derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J Takuma S Burkhoff D Wang J | 2001 | Nat Med2001，7，： | 1 |
| 3 | Neovaseularization of ischemic myocardium by human bone marrow derived angioblasts prevents eardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schusitc 'r MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 4 | Neovascularization of ischemic myocardium by human bone-marrow-derived amgioblasts prevents cardiomyocyte apoptosis,reduces remodeling and umproves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 5 | Proliferative activity of benign and neoplastic endocervical epithelium and correlation with HPV DNA detection显示文摘 | Isacson C Szabolcs M J | 2002 | Int J Gynecol Pathol2002，21，1： | 1 |
| 6 | Dysrcgulation of cellular pro- liferation and apoptosis mediates human autosomal dominant polycystic kidney disease ( ADPKD ) 显示文摘 | Lanoix J D'Agati V Szabolcs M | 1996 | Oncogene1996，13，6： | 1 |
| 7 | Neovascularization of ischcmic myocardium by human bonemarrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 8 | Neovascularization of ischemie myocardium by human bone - marrow - derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 9 | Neovasculariza- tion of ischemic myocardium by human bone-marrow-derived an- gioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J et ak | 2010 | Nat Med2010，7，： | 1 |
| 10 | Neovascular-ization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 11 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | KOCHER A A SCHUSTER M D SZABOLCS M J | 2001 | Nat Med2001，7，4： | 1 |
| 12 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 13 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function 显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 14 | Neovascularization ofischemic myocardium by human bone marrow-derived angioblastsprevents cardiomyocyte apoptosis reduces remodeling and improvescardiac function显示文摘 | Kocher A A Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 15 | Neovascu- larization of ischemic myocardium by human bone-marrow- derived angioblasts prevents cardiomyocyte apoptosis, re- duces remodeling and improves cardiac function 显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
| 16 | Neovscularization of ischemic myocardium by human-bone-marrow-derived angioblasts prevent cardiomyocyte apoptosis,reduces remodeling and improve cardiac function显示文摘 | KOCHER A A SCHUSTER M J SZABOLCS | 2001 | NatureMedicine2001，7，： | 1 |
| 17 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | 2001 | Nat Med2001，7，： | 1 |
| 18 | Neovascu1arization of ischemic myocardium by human bone-marrow -derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster M D Szabolcs M J | 2001 | Nat Med2001，7，： | 1 |
| 19 | Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis,reduces remodeling and improves cardiac function显示文摘 | Kocher AA Schuster MD Szabolcs M J | | 0，，： | 1 |
| 20 | 显示文摘 | Kocher AA Sxhuster MD Szabolcs M J | 2001 | Nat Med2001，7，4： | 1 |
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