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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease 显示文摘 | Sugai E Vazquez H Nachman F | 2006 | Clin Gastroenterol Hepatol2006，4，9： | 1 |
| 3 | Pun- gent quanlities of sanshool-related compounds evalua- ted by a sensory test and activation of rat TRPV1 显示文摘 | SUGAI E MORIMITSU Y IWASAKI Y | 2005 | Biosci Biotechnol Biochem2005，69，10： | 1 |
| 4 | In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet显示文摘 | Sugai E Yoshioka W Kakeyama M | 2014 | J Appl Toxicol2014，34，3： | 1 |
| 5 | Treatment of epilepsy in se- verely disabled children with bilateral brain malformations显示文摘 | Saito Y Sugai K Nakagawa E | 2009 | Neurol Sei2009，277，12： | 1 |
| 6 | Serum transforming growth factor batal levels increase in response to successful anti- infammatory therapy in ulcerative colitis显示文摘 | Samhuelli A Diez RA Sugai E | 2000 | Aliment Pharmacol Ther2000，14，11： | 1 |
| 7 | In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin modulates dys-regulation of the lipid metabolism in mouse offspring fed a high-calorie diet显示文摘 | Sugai E Yoshioka W Kakeyama M | 2014 | J Appl Toxicol2014，34，3： | 1 |
| 8 | Brunner's gland ade- noma with a focus of p53-positive atypical glands显示文摘 | Fujimaki E Nakamura S Sugai T | 2000 | J Gastro- enterol2000，35，2： | 1 |
| 9 | Two dimentional modeling of slot excited surface wave in bounded planar surface wave plasmas显示文摘 | ABDEL-FATTAH E GHANASHEV I SUGAI H | 2000 | Jpn J Appl Phys2000，39，： | 1 |
| 10 | Estimation of automotive tire force characteristics using wheel velocity 显示文摘 | One E Asano K Sugai M | 2003 | Control Engineering Practice2003，，11： | 1 |
| 11 | Pungent qualities of sanshool - related compounds evaluated by a sensory test and activation of rat TRPVI显示文摘 | Sugai E | 2005 | Bioscience Biotechnology and Biochemistry2005，69，10： | 1 |
| 12 | Numerical 3D simula- tion of surface wave excitation in planar-type plasma pro- cessing device with a corrugated dielectric plate 显示文摘 | Fattah E A Ganachev I Sugai H | 2011 | Yac- uum2011，，3： | 1 |
| 13 | Pungent qualities of sanshool -related compounds evaluated by a sensory test and activation of rat TRPVl 显示文摘 | Sugai E Morimitsu Y Iwasaki Y | 2005 | Bioscience Biotechnology and Biochemistry2005，69，10： | 1 |
| 14 | Environmental influences on the microbial degradation of exxon valdez oil on the shorelines of prince william sound,alaska显示文摘 | SUGAI S F LINDSTROM J E BRADDOCK J F | 1997 | Environ Sci Technol1997，31，： | 1 |
| 15 | Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1显示文摘 | SUGAI E MORIMITSU Y IWASAKI Y | 2005 | Biosciencet Biotechnology and Biochemistry2005，69，10： | 1 |
| 16 | Apple lalent spherical virus vectors for reliable and effective virus induced gene silencing among a broad range of plants including tobacco,tomalo,Arabidapsis thaliana ,cucurbits,and legumes显示文摘 | IGARASHI A YAMAGATA K SUGAI T TAKAHASHI Y SUGAWARA E TAMURA A YAEGASHI H YAMAGISHI N TAKAHASHI T ISOGAI M TAKAHASHI H YOSHIKAWA N | 2009 | Virolog2009，386，2： | 1 |
| 17 | Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of Rat TRPV1显示文摘 | Sugai E Morimitsu Y Iwasaki Y | | 0，，： | 1 |
| 18 | Environmental influences on the microbial degradation of Exxon Valdez oil on the shorelines of Prince William Sound, Alaska 显示文摘 | SUGAI S F LINDSTROM J E BRADDOCK J F | 1997 | Environ Sci Technol1997，31，： | 1 |
| 19 | Brain perfusion SPECT and EEG findings in children with autism spectrum disorders and medically intractable epilepsy显示文摘 | Sasaki M Nakagawa E Sugai K | 2010 | Brain Develop2010，32，9： | 1 |
| 20 | Grappling with press forming used magnesium alloy in Niigata prefecture显示文摘 | TANABE H YAMAZAKI E SUGAI H | 2003 | Journal of the Japan Society for Technology of Plasticity2003，44，1： | 1 |
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