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| 1 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 2 | Paramutation: A Heritable Change in Gene Expression by Allelic Interactions In Trans显示文摘Epigenetic 基因规定通过有丝分裂、有时平的 meiotic 包含基因活动状态的稳定的繁殖,没有在 DNA 的变化的房间部门定序。Paramutation 是在稳定地通过有丝分裂以及成熟分裂被播送的基因表示包含变化的 epigenetic 现象。这些可继承的变化被调停由在在不同染色体上的相应 DNA 序列之间的 trans 相互作用。在这些期间在 trans 相互作用, epigenetic 信息从基因的一等位基因被转移到一样的基因的另一等位基因,在基因表示导致一个变化。尽管 paramutation 开始在植物被发现,它最近也在哺乳动物被观察了,建议位于 paramutation 下面的机制可能 evolutionarily 被保存。最近的调查结果点到为在 paramutation 过程的小 RNA 的一个关键角色。在老鼠,,小 RNA 在玉米显得足够导致 paramutation,它似乎不是在这个过程的唯一的运动员。在这评论,潜在的机制在与各种各样的 paramutation 现象的关系被讨论。 | Maike Stam | 2009 | Molecular Plant2009，2，4： | 2 |
| 3 | Enhanced biodegradation of aromatic pollutants in cocultures of anaerobic and aerobic bacterial consortia 显示文摘 | FELDJ A STAMS A J M KATO M | 1995 | Antonievall Leeuwenhoek1995，67，： | 1 |
| 4 | Randomized,placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis显示文摘 | de Bruijn SF Stam J | 1999 | Stroke1999，30，3： | 1 |
| 5 | On the Uses of Theory 显示文摘 | STAM H | 2006 | The General Psychologist2006，，2： | 1 |
| 6 | Randomized, placebo-controlled trial of antico- agulant treatment with low-molecular-wight heparin for cerebral sinus thrombosis显示文摘 | de Brujin SF Stam J | 1999 | Storke1999，30，： | 1 |
| 7 | The evolution and nature of young firm networks:A longitudinal perspective显示文摘 | Schutjens V Stam E | 2003 | Small Business Economics2003，21，： | 1 |
| 8 | Thrombosis of the cerebral veins and sinuses显示文摘 | Stam J | 2005 | N Engl J Med2005，352，17： | 1 |
| 9 | Theoretical proportion of donor genome in nearisogenic lines of self-fertilizers bred byback-crossing显示文摘 | Stam P Zeven A C | 1981 | Euphytica1981，30，： | 1 |
| 10 | Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis:a prospective study显示文摘 | Stam J Majoie CB van Delden OM | | 0，，05： | 1 |
| 11 | The genetic overlap of attention deficit hyperactivity disorder and autistic spectrum disorder显示文摘 | Stam AJ Schothorst PF Vorstman JA | 2009 | Appl Clin Genet2009，2，： | 1 |
| 12 | Impaired renal function is associated with markers of endothelial dysfunction and increased inflammatory activity显示文摘 | Stam F van Guldener C Schalkwijk CG | 2003 | Nephrol Dial Transplant2003，18，5： | 1 |
| 13 | Analysis of α1L-Adrenoceptor pharmacology in rat small mesenteric artery 显示文摘 | Van der Graaf P H Saxerta P R | 1999 | Br J Pharmacol1999，127，： | 1 |
| 14 | Investigation of the dynamics underlying periodic complexes in the EEG显示文摘 | Stam CJ Vliegen JH Nicolai J | 1999 | Biol Cybern1999，80，： | 1 |
| 15 | Randomized,placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis显示文摘 | De Bruijn SF Stam J | 1999 | Stroke1999，30，3： | 1 |
| 16 | Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke显示文摘 | Immink RV Montfrans GA Stam J | 2005 | Stroke2005，36，12： | 1 |
| 17 | Ventilator-Associated Pneumonia and Frequency of Circuit Changes显示文摘 | Stam A M | 1998 | Am J Infect Control1998，26，1： | 1 |
| 18 | Thrombosis of the cerebral veins and sinuses显示文摘 | Stam J | | 0，，： | 1 |
| 19 | Small-world and scale-free organization of voxel-based resting-state functional connectivity in the human brain 显示文摘 | van den Heuvel MP Stam CJ Boersma M | 2008 | Neuroimage2008，43，3： | 1 |
| 20 | Analysis of end user securi- ty behaviors显示文摘 | Stanton J Stam K Mastrangelo P | 2005 | Computers & Security2005，24，2： | 1 |
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