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| 1 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Nerve growth factor downregulates inflammatory response in human monocytes through TrkA显示文摘 | Prencipe G Minnone G Strippoli R | 2014 | J Immunol2014，192，7： | 1 |
| 3 | Cold single-strand conformation polymorphism analysis:optimization for detection of APC gene mutations in patients with familial Adenomatous polyposis显示文摘 | Strippoli P Sarchielli S Santucci R | 2001 | Int J Mol Med2001，8，5： | 1 |
| 4 | Clinical and therapeutic aspects of diabetic nephropathy显示文摘 | Strippoli G F Di Paolo S Cincione R | 2003 | J Nephrol2003，16，4： | 1 |
| 5 | Nerve growth factor downregulates inflammatory response in human monocytes through TrkA显示文摘 | Prencipe G Minnone G Strippoli R | 2014 | J Immunol2014，192，7： | 1 |
| 6 | Epithelial-to- mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappa B/Snaill pathway 显示文摘 | Strippoli R Benedicto I P6rez Lozano ML | 2008 | Dis Model Mech2008，1，45： | 1 |
| 7 | p38 maintains E-cadherin expression by modulating TAK1 - NF-kappa B during epithelial-to-mesenchymal transition 显示文摘 | STRIPPOLI R BENEDICTO I FORONDA M | 2010 | J Cell Sci2010，123，24： | 1 |
| 8 | Inhibition of transtbr- ming growth factor-activated kinase 1 ( TAK1 ) blocks and reverses epi- thelial to mesenchymal transition of mesothelial cells 显示文摘 | Strippoli R Benedicto I Perez Lozano ML | 2012 | PIoS Otle2012，7，31： | 1 |
| 9 | RAC1/p38 MAPK signaling pathway controlsb1 integrin-induced interleukin-8 production in human natural killer cells显示文摘 | Mainiero F Soriani A Strippoli R Jacobelli J Gismondi A Piccoli M | 2000 | Immunity2000，12，1： | 1 |
| 10 | Inhibition of transforming growth factor-activated kinase 1(TAK1)blocks and reverses epithelial to mesenchymal transition of mesothelial cells显示文摘 | Strippoli R Benedicto I Perez Lozano ML | 2012 | PLoS One2012，7，31： | 1 |
| 11 | HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway显示文摘 | Toschi E Bacigalupo I Strippoli R | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 12 | Epithelial - to - mesenchymal transition of peritoneal mesothelial cells is reg- ulated by an ERK/NF - kappaB/Snaill pathway 显示文摘 | Strippoli R Benedicto I Perez LM | 2008 | Dis Model Mech2008，1，45： | 1 |
| 13 | p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial- to-mesenchymal transition显示文摘 | Strippoli R Benedicto I Foronda M | 2010 | J Cell Sci2010，123，24： | 1 |
| 14 | Clinical and therapeutic aspects of diabetic nephropathy显示文摘 | Strippoli GF Di Paolo S Cincione R | 2003 | J Nephrol2003，16，4： | 1 |
| 15 | Epithelial- to-mesenchymal transition of peritoneal mesothelial ceils is regulated by an ERK/NF-κB/Snaillpathway 显示文摘 | Strippoli R Benedicto I Perez Lozano M L | 2008 | Dis Model Mech2008，1，45： | 1 |
| 16 | In vitro activity of propyl gallate-azole drug combination against fluconazole and itraconazole-resistant Candida albicans strains显示文摘 | D' Auria FD Tecta M Strippoli R | 2001 | Lett Appl Microbiol2001，32，4： | 1 |
| 17 | Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an erk/nf-kappab/snail1 pathway显示文摘 | Strippoli R Benedicto I Perez Lozano ML | 2008 | Dis Model Mech2008，1，45： | 1 |
| 18 | In vitro activity of propylgallate-azole drug combination against fluconazole- and itraconazole-resistant Candida albicans strains 显示文摘 | D'Auria F D Tecca M Strippoli R | 2001 | Lett App 1 Microbiol2001，32，： | 1 |
| 19 | Epithelial-tcymesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF kappaB/Snaill pathway显示文摘 | Strippoli R Benedicto I Perez Lozano ML etal | 2008 | Dis Model Meeh2008，1，45： | 1 |
| 20 | Clinical and therapeutic aspects of diabetic nephropathy显示文摘 | Strippoli GF Di Paolo S Cincione R | 2003 | J Nephrol2003，16，： | 1 |
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