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| 1 | Laparoscopic surgery:A qualified systematic review显示文摘AIM: To review current applications of the laparoscopic surgery while highlighting the standard procedures across different fields.METHODS: A comprehensive search was undertaken using the Pub Med Advanced Search Builder. A total of 321 articles were found in this search. The following criteria had to be met for the publication to be selected: Review article, randomized controlled trials, or metaanalyses discussing the subject of laparoscopic surgery. In addition, publications were hand-searched in the Cochrane database and the high-impact journals. A total of 82 of the findings were included according to matching the inclusion criteria. Overall, 403 full-text articles were reviewed. Of these, 218 were excluded due to not matching the inclusion criteria. RESULTS: A total of 185 relevant articles were identified matching the search criteria for an overview of the current literature on the laparoscopic surgery. Articles covered the period from the first laparoscopic application through its tremendous advancement over the last several years. Overall, the biggest advantage of the procedure has been minimizing trauma to the abdominal wall compared with open surgery. In the case of cholecystectomy, fundoplication, and adrenalectomy, the procedure has become the gold standard without being proven as a superior technique over the open surgery in randomized controlled trials. Faster recovery, reduced hospital stay, and a quicker return to normal activities are the most evident advantages of the laparoscopic surgery. Positive outcomes, efficiency, a lower rate of wound infections, and reduction in the perioperative morbidity of minimally invasive procedures have been shown in most indications. CONCLUSION: Improvements in surgical training and developments in instruments, imaging, and surgical techniques have greatly increased safety and feasibility of the laparoscopic surgical procedures. | Alexander Buia Florian Stockhausen Ernst Hanisch | 2015 | World Journal of Methodology2015，5，4： | 15 |
| 2 | Evaluation of 4-fluorobenzoyl-FALGEA-NH2 as a position emission tomography tracer for epidermal growth factor receptor mutation variant Ⅲ imaging in cancer显示文摘 | DENHOIT C L BINDERUP T STOCKHAUSEN M T | 2011 | Nucl Med Bid2011，38，4： | 1 |
| 3 | Cell adhesion and EGFRactivation regulate EphA2 expression in cancer 显示文摘 | Larsen AB Stockhausen MT Poulsen HS | 2010 | Cell Signal2010，22，4： | 1 |
| 4 | Preoperative activation and intraoperative stimulation of language-related areas in patients with glioma 显示文摘 | Herholz K Reulen HJ yon Stockhausen HM | 1997 | Neurosurgery1997，41，： | 1 |
| 5 | Regulation of the Notch target gene Hes-I by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells显示文摘 | Stockhausen MT Sjolund J Axelson H | 2005 | Exp Cell Res2005，310，： | 1 |
| 6 | Cell adhe sion and EGFR activation regulate Eph A2 expression in caneer显示文摘 | Larsen AB Stockhausen MT Poulsen HS | 2010 | Cell Signal2010，22，4： | 1 |
| 7 | Irinotecan and bevacizumab in recurrent glioblastoma multiforme显示文摘 | Jakobsen JN Hasselbalch B Stockhausen MT | 2011 | Expert Opin Pharmacother2011，12，5： | 1 |
| 8 | Notch signa- ling and brain tumors显示文摘 | Stockhausen MT Kristoffersen K Poulsen HS | 2012 | Adv Exp Med Biol2012，727，： | 1 |
| 9 | Some new aspects for the modelling of isothermal remanent magnetization acquisition curves by cumulative log Gaussian functions显示文摘 | STOCKHAUSEN H | 1998 | Geophys Res Let1998，25，： | 1 |
| 10 | Geomagnetic palaeosecular variation (0-13 000 yr BP) as recorded in sediments from three maar lakes from the West Eifel (Germany)显示文摘 | Stockhausen H | 1998 | Geophysical Journal International1998，135，： | 1 |
| 11 | The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies. | Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan | 2021 | Bone Research2021，9，4： | 1 |
| 12 | The NOTCH pathway in cancer:differentiation gone awry显示文摘 | SJOLUND J MANETOPOULOS C STOCKHAUSEN M T | | 0，，17： | 1 |
| 13 | Metabolic and cardiovascular adaptation and performance of professional tennis players 显示文摘 | KEULS J STOCKHAUSEN W POKAN R | 1991 | Deutsche Medizinische Woehenschrift1991，116，20： | 1 |
| 14 | The Notch pathway in cancer:Differentiation gone awry显示文摘 | Sjolund J Manetopoulos C Stockhausen MT | 2005 | Eur J Cancer2005，41，17： | 1 |
| 15 | Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells显示文摘 | Stockhausen MT Sjolund J Axelson H | 2005 | Exp Cell Res2005，310，1： | 1 |
| 16 | The Notch pathway in cancer: Differentiation gone awry显示文摘 | Jonas Sj?lund Christina Manetopoulos Marie-Thérése Stockhausen H?kan Axelson | 2005 | European Journal of Cancer2005，，17： | 1 |
| 17 | Ford P2000 hydrogen engine design and vehicle development program 显示文摘 | STOCKHAUSEN W F NATKIN R J KABAT D M | 2002 | SAE Paper2002，，： | 1 |
| 18 | Regulation of the Notch target gcnc Hcs-l by TGFalpha induced Ras/MAPK signaling in human ncuroblastoma cells 显示文摘 | Stockhausen MT Sjolund J Axelson H | 2005 | Exp Cell Rcs2005，310，1： | 1 |
| 19 | Evaluation of 4- F-18 fluorobenzoyi-FAL- GEA-NH2 as a positron emission tomography tracer for epidermal growth factor receptor muta- tion variant Ⅲ imaging in cancer显示文摘 | Denholt C L Binderup T Stockhausen M T | 2011 | Nucl Med Biol2011，38，4： | 1 |
| 20 | Cell adhesion and EGFR activation regulate EphA2 expression in cancer 显示文摘 | Larsen AB Stockhausen MT Poulsen HS | 2010 | Cell Signal2010，22，4： | 1 |
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