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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Hongda New Material Improved Silicone Rubber Industrial Chain显示文摘 | Jiangsu Hongda Chemical New Material Co.,Ltd.(Hongda New material,SZ:002211)is located in Yangzhong,Jiangsu province.It got listed in Shenzhen Stock Exchange onFebruary 1st,2008.(CCR2008, No.3)The company mainly produces silicone monomersand high-temperature silicone rubber series.The capacity of silicone monomers and prod-ucts of silicone rubber series reached 30 000 t/a and 28 000 t/a respectively at the end of2007.The sales volume of high-temperature silicone rubber compound has grown steadilyat 30% a year.The company’s high-temperature silicone rubber capacity is still beingexpanded today and will hopefully reach 50 000 t/a at the end of 2008. | 2008 | China Chemical Reporter2008，，25： | 16 |
| 3 | Acquired segmental colonic hypoganglionosis in an adult Caucasian male:A case report显示文摘BACKGROUND Hypoganglionosis is a rare condition that most often presents with abnormal gastrointestinal transit and usually arises in early childhood or adolescence. Two types have been described(Type I and Type II). The adult-onset form(acquired hypoganglionosis) is extremely uncommon and is thought to arise due to cellular remodelling as a result of chronic inflammation. It differs from Hirschprung's disease in that there is a reduction in ganglion cells in the colonic neural plexuses as opposed to being completely absent.CASE SUMMARY A 31 year-old male presented to hospital with recurrent abdominal pain and vomiting over thirteen months. Abdominal computed tomography scans demonstrated thickening and stranding affecting the transverse, descending and sigmoid colon. Endoscopic appearances were non-specific but confirmed a mixed picture of mucosal inflammation and necrosis in various stages of healing.Numerous investigations were performed to elucidate an underlying aetiology but neither an infective nor ischaemic cause could be proven. Biopsy features were not typical of inflammatory bowel disease. Due to persistence of his symptoms and failure of medical management, a segmental colectomy was performed. Histological examination of the specimen revealed an unexpected finding of segmental hypoganglionosis. Complete surgical excision of the diseased segment of colon was curative and since his operation the patient has had no recurrence of symptoms requiring hospitalisation.CONCLUSION Our case serves to raise awareness of acquired hypoganglionosis as a rare condition that can result from chronic colitis. | Allan MF Kwok Andrew B Still Kimberly Hart | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 3 |
| 4 | An Approach to Automatic Display Layout Using Combinatorial Optimization Algorithms显示文摘 | P Luder R Ernst S Stille | 1995 | Software:Practice and Experience1995，25，11： | 2 |
| 5 | Acute pancreatitis显示文摘 | Dubagunta S Still CD Komar MJ | 2001 | J Am Osteopath Assoc2001，，： | 1 |
| 6 | Inferior survival of hydroxyapatite versus titanium-coated cups at 15 years 显示文摘 | Stilling M Rahbek O Sballe K | 2009 | Clinical Orthopaedics and Related Research2009，467，11： | 1 |
| 7 | Numerical calculations for prediction of grout spread with account of filtration and varying aperture显示文摘 | Eriksson M Stille H Andersson J | 2000 | Tunneling and Underground Space Technology2000，15，4： | 1 |
| 8 | The palladium-catalyzed cross-coupling reactions of organotin reagents with organic eleetrophiles显示文摘 | Stille J K | 1986 | Angew Che Int Ed Eng1986，25，： | 1 |
| 9 | Synthesis and Properties of Rigid-Rod Polyquinolines 显示文摘 | Sybert P D Beever W H Stille J K | 1981 | Macromolecules1981，1981，： | 1 |
| 10 | Electricity production from alkalophic organisms显示文摘 | Akiba T Bennetto H P Stilling J L | 1987 | Biotechnol Lett1987，9611，： | 1 |
| 11 | Mechanisms of the palladium-catalyzed -Couplings of acid chlorides with organotin reagents显示文摘 | Jeff W L Stille J K | 1983 | J Am Chem Soc1983，105，： | 1 |
| 12 | Prevalence,characteristics and natural course of inappropriate sinus tachycardia显示文摘 | Still AM Raatikainen P Ylitalo A | 2005 | Europace2005，7，： | 1 |
| 13 | Suppression of the coffee-ring effect by shape-dependent capillary interactions显示文摘 | Yunker P J Still T Lohr M A Yodh A G | | 0，，7360： | 1 |
| 14 | Linkages between Manufacturing and Services in Germany显示文摘 | Stille F | 2002 | Research Note DIW Berlin2002，，： | 1 |
| 15 | Pulmonary Artery Sling: A New Diagnostic Tool and Clinic Review显示文摘 | Rheuban K S Ayres N Still J G | 1982 | Pediatrics1982，69，2： | 1 |
| 16 | Rare earth ele- ments and Sr and Nd isotopic compositions of dissolved and suspended loads from small river systems in the Vosges Motm- tains (France), the river Rhine and groundwater 显示文摘 | TRICCA A STILLE P STEINMANN M | 1990 | Chemical Geology1990，160，： | 1 |
| 17 | Atherosclerosis as a sequela of chronic Chlamydia pneumoniae infection显示文摘 | Stille W Dittmann R | 1998 | Herz1998，23，： | 1 |
| 18 | Hydrophobic Strip-of-helix algorithm for selection of T cell-presented peptides 显示文摘 | Stille CJ Thomas LJ Reyes VE | 1987 | Mol Immunol1987，24，10： | 1 |
| 19 | Computer-Simulated flow of grouts in jointed rock显示文摘 | HASSLER L HAKANSSON U STILLE H | 1992 | Tunneling and Underground Space Tech1992，7，4： | 1 |
| 20 | GLEAMS:Groundwater loading effects of agricultural management systems显示文摘 | Leonard R A Knisel W G Still D A | 1987 | Trans Amer Soc of Agri Engrs1987，30，5： | 1 |
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