|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Calculation of the nonlinear optical properties of molecules 显示文摘 | Kurtz H A Stewart J J P Dieter K M | 1990 | Journal of Computa- tional Chemistry1990，11，1： | 1 |
| 3 | Gon- adotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo 显示文摘 | MORGAN K STEWART A J MILLER N | 2008 | Cancer Res2008，68，15： | 1 |
| 4 | The Role of Climate for Innovation in En- hancing Business Performance: The Case of Design Firms显示文摘 | PANUWATWANICH K STEWART R A MO- HAMED S | 2008 | Engineering Construction and Architectur- al Management2008，15，5： | 1 |
| 5 | Biofilm resistance to antimicrobial agents显示文摘 | XU K D McFETERS G A STEWART P S | 2000 | Microbiology2000，146，3： | 1 |
| 6 | Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver显示文摘 | McClung J K Danner D B Stewart D A | 1989 | Biochem Biophys1989，16，4： | 1 |
| 7 | Evidence suggesting that a chronic disease self-management program can improve health status while reducing hospitalization:A Randomized Trial显示文摘 | Lorig K Sobel U Stewart A | 1999 | Medical Care1999，37，1： | 1 |
| 8 | Using ProMED-Mail and MedWorm blogs for cross-domain pattern analysis in epidemic intelligence显示文摘 | Stewart A Denecke K | 2010 | Stud Health Technol Inform2010，160，1： | 1 |
| 9 | Heat-related illness 显示文摘 | Becker J A Stewart L K | 2011 | Am Fam Physician2011，83，11： | 1 |
| 10 | Evidence suggesting that a chronic disease self-management pro- gram can improve health status while reducing hospitali- zation: a randomized trial显示文摘 | Lorig K R Sobel D S Stewart A L | 1999 | Med Care1999，37，1： | 1 |
| 11 | 显示文摘 | KURTZ 1t A STEWART J J P DIETER K M | 1990 | J CompChem1990，11，1： | 1 |
| 12 | Three-dimensional computed tomography analysis of airway volume changes after rapid maxillary expansion显示文摘 | Smith T Ghoneima A Stewart K | 2012 | Am J Orthod Dentofacial Orthop2012，141，5： | 1 |
| 13 | Assessing cloud phase conditions 显示文摘 | Stewart G George A I Alexei V K | 2001 | J Appl Meteor2001，40，： | 1 |
| 14 | An evaluation of modified μ-Law compaading to reduce the PAPR of OFDM systems显示文摘 | Vallavaraj A Stewart B G and Harrison D K | 2010 | AEU-International Journal of Electronics and Communications2010，64，9： | 1 |
| 15 | Structural reliability of concrete bridges including improved chloride-induced corrosion models 显示文摘 | Vu K A T Stewart M G | 2000 | Struetural Safety2000，22，4： | 1 |
| 16 | Current issues in mouse ge- nome engineering显示文摘 | Glaser S Anastassiadis K Stewart A F | 2005 | Nat Genet2005，37，： | 1 |
| 17 | Estimating historical heating and cooling need: per capita degreeday显示文摘 | Downton M W Stewart T R Miller K A | 1988 | Journal of Applied Meteorology1988，27，1： | 1 |
| 18 | Chronic disease self-management program: 2-year health status and health care utilization outcomes显示文摘 | Lorig K R Ritter P Stewart A L | 2001 | Med Care2001，39，11： | 1 |
| 19 | Evidence suggesting that a chronic disease self-management program can improve health status while reducing hospitalization: a randomized trial显示文摘 | Eorig K Sobel D Stewart A | 1999 | Med Care1999，37，1： | 1 |
| 20 | Effeets of cast film fabrication variables on structure development and key stretch film properties 显示文摘 | Degroot J A Doughty A T Stewart K B | 1994 | Journal of Applied Polymer Seien ee1994，52，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员