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| 1 | Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study显示文摘AIM: To prospectively analyze the impact of increased intestinal permeability(IP) on mortality and the occurrence of infections in patients with cirrhosis.METHODS: IP was quantified using the lactulose/mannitol(L/M) test in 46 hospitalized patients with cirrhosis(25 Child-Pugh A/B, 21 Child-Pugh C) and in 16 healthy controls. Markers of inflammation [LPSbinding protein, Interleukin-6(IL-6)] and enterocyte death [intestinal fatty-acid binding protein(I-FABP)] were determined in serum using enzyme-linked immunosorbent assays. Patients were followed for one year and assessed for survival, liver transplantation, the necessity of hospitalization and the occurrence of bacterial infections. The primary endpoint of the study was defined as differences in survival between patients with pathological and without pathological lactulose/mannitol test.RESULTS: Thirty-nine(85%) patients with cirrhosis had a pathologically increased IP index(L/M ratio > 0.07) compared to 4(25%) healthy controls(P < 0.0001). The IP index correlated with the ChildPugh score(r = 0.484, P = 0.001) and with serum IL-6(r = 0.342, P = 0.02). Within one year, nineteen(41%) patients developed a total of 33 episodes of hospitalization with bacterial or fungal infections. Although patients who developed spontaneous bacterial peritonitis(SBP)(n = 7) had a higher IP index than patients who did not(0.27 vs 0.14, P = 0.018), the baseline IP index did not predict time to infection, infection-free survival or overall survival, neither when assessed as linear variable, as tertiles, nor dichotomized using an established cut-off. In contrast, model for end-stage liver disease score, Child-Pugh score, the presence of ascites, serum IL-6 and I-FABP were univariate predictors of infection-free survival.CONCLUSION: Although increased IP is a frequent phenomenon in advanced cirrhosis and may predispose to SBP, it failed to predict infection-free and overall survival in this prospective cohort study. | Anika Vogt Philipp A Reuken Sven Stengel Andreas Stallmach Tony Bruns | 2016 | World Journal of Gastroenterology2016，22，11： | 8 |
| 2 | Primary total hip arthroplasty versus hemiarthmplasty for displaced int- racapsular hip fractures in older patients:systematic rev- iew显示文摘 | Hopley C Stengel D Ekkemkamp A | 2010 | BMJ2010，340，： | 1 |
| 3 | Nesfatin-1 immu-noreactivity in rat brain and spinal cord autonomic nuclei显示文摘 | Goebel M Stengel A Wang L | 2009 | Neurosci Lett2009，452，3： | 1 |
| 4 | Corticotropin-relcasing factor signaling and visceral response to stress 显示文摘 | Stengel A Tache Y | 2010 | Exp Biol Med2010，235，10： | 1 |
| 5 | Effects of mutations and glycosylations on STS activity: a site-directed mutagenesis study显示文摘 | Stengel C Newman S P Day J M Tutill H J Reed M J Purohit A | 2008 | Molecular and Cellular Endocrinology2008，283，1： | 1 |
| 6 | Identificationand characterization of nesfatin-1 immunoreactivity in en-docrine cell types of the rat gastric oxyntic mucosa 显示文摘 | Stengel A Goebel M Yakubov I | 2009 | Endocrinology2009，150，1： | 1 |
| 7 | Localization of nesfatin- 1 neurons in the mouse brain and functional implication 显示文摘 | Goebel-Stengel M Wang L Stengel A | 2011 | Brain Res2011，1396，： | 1 |
| 8 | irisin as a muscle-derived hor- mone stimulating thermogenesis-A critical update 显示文摘 | Hofmann T Elbelt U Stengel A | 2014 | Peptides2014，54，： | 1 |
| 9 | Nesfatin- 1 immunoreactivity in rat brain and spinal cord autonomic nuclei 显示文摘 | Goebel M Stengel A Wang L | 2009 | Neurosci Lett2009，452，3： | 1 |
| 10 | Ghrelin-a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach 显示文摘 | Stengel A Tache Y | 2012 | Front Neurosci2012，6，： | 1 |
| 11 | Interaction between gastric and upper small intesti-nal hormones in the regulation of hunger and satiety:ghrelin and chole-cystokinin take the central stage 显示文摘 | Stengel A Tach6 Y | 2011 | Curr Protein Pept Sci2011，12，4： | 1 |
| 12 | Probabilistic Reasoning for Intelligent Wind Shear Avoidance显示文摘 | Stratton D A Stengel R F | 1992 | Guidance1992，15，1： | 1 |
| 13 | A role for corticotropin-re- leasing factor in functional gastrointestinal disorders 显示文摘 | Tache Y Kiank C Stengel A | 2009 | Curr Gastroenterol Rep2009，11，： | 1 |
| 14 | Minireview: nesfatin-1 an emerging new player in the brain-gut endocrine and metabolic axis显示文摘 | Stengel A Tachs Y | 2011 | Endocrinology2011，152，11： | 1 |
| 15 | Nesfatiwl: a novel inhibi- tory regulator of food intake and body weight显示文摘 | Stengel A Goebel M Tach6 Y | 2011 | Obes Rev2011，12，4： | 1 |
| 16 | nesfa-tin-1 immunoreactivity in rat brain and spinal cord au-tonomic nuclei 显示文摘 | GOEBEL M STENGEL A WANG L X | 2009 | Neuroscience Letters2009，452，3： | 1 |
| 17 | Hematological findings among styrene-exposedworkers in the reinforced plastics industry显示文摘 | Stengel B Touranchet A Boiteau H L | 2001 | Occupational Environmental Health2001，62，： | 1 |
| 18 | Localization of nesfatin-1 neurons in the mousebrain and functional implication 显示文摘 | GOEBEL-STENGEL M WANG L X STENGEL A | 2011 | Brain Research2011，1396，： | 1 |
| 19 | Retinoblastoma/ p107/p130 Pocket Proteins 显示文摘 | Stengel K R Thangavel C Solomon D A | 2009 | J Biol Chem2009，284，19： | 1 |
| 20 | Identification and characterization of Nnesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa显示文摘 | Stengel A Goebel M Yakubov I | | 0，，： | 1 |
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