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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Sonographic signs of neutropenic enterocolitis显示文摘瞄准:与 neutropenic 小肠结肠炎在病人在诊断和后续的时间调查 sonographic 特征。方法:在有 neutropenic 小肠结肠炎的 14 个病人的 sonographic 调查结果被描述并且评估了考虑症状和临床的结果。结果:在有 neutropenic 小肠结肠炎的所有病人, ileocoecal 区域涉及墙变厚 >10 公里。一个透壁的煽动性的模式,变厚的肠墙的亢奋的由脉管形成和免费腹的液体是普通调查结果。肠墙的 sonographically 揭示的厚度与致命的结果(P<0.03 ) 被联系。在 11 个幸存病人,临床的症状的改进被肠的墙厚度的进步减小伴随。结论:肠的高端 sonography 是为诊断的一个有用工具,对预后的评价和有 neutropenic 小肠结肠炎的病人的后续。ultrasonographically 揭示的肠厚度反映严厉和疾病的功课,并且似乎为临床的结果预兆。 | Christoph F Dietrich Stella Hermann Stefan Klein Barbara Braden | 2006 | World Journal of Gastroenterology2006，12，9： | 2 |
| 3 | Incidence and outcome of radial artery occlusion following transradial artery coronary angplasty显示文摘 | Stella PR Kiemeneiji F Laarman GJ | 1997 | Cathet Cardiovasc Diagn1997，40，2： | 1 |
| 4 | Circulating plasma factors induce tubular and glomerular alterations in septic burns patients显示文摘 | Mariano F Cantaluppi V Stella M | 2008 | Crit Care2008，12，2： | 1 |
| 5 | Plasma homocysteine in early and late pregnancies complicatedwith preeclampsia and isolated intrauterine growth restriction显示文摘 | Anna R Baviera G Corrado F Ientile R Granese D Stella NC | 2004 | Acta Obstet Cynecol Scand2004，83，2： | 1 |
| 6 | Liquidchromatography-mass spectrometry methods for urinarybiomarker detection in metabonomic studies with application tonutritional studies 显示文摘 | Legido-Quigley C Stella C Perez-Jimenez F | 2010 | Biomed Chromatogr2010，247，： | 1 |
| 7 | Self-organization of multiple spatial and context memories in the hippocampus 显示文摘 | Stella F Cerasti E Si B | 2012 | Neurosci Biobehav Rev2012，36，7： | 1 |
| 8 | Regional citrate anticoagulationin critically ill patients treated with plasma filtration and adsorption显示文摘 | Mariano F Tetta C Stella M | 2004 | Blood Purification2004，22，3： | 1 |
| 9 | Retrograde ileoscopy in chronic nonbloody diarrhea:a prospective,case-control study显示文摘 | Morini S Lorenzetti R Stella F | | 0，，07： | 1 |
| 10 | Endovaseular treatment of common carotid artery dissection via the superficial temporal artery显示文摘 | Stella N Palombo G Filippi F | 2010 | J Endovasc Ther2010，17，4： | 1 |
| 11 | Incidence and outcome of radial artery occlusion following transradial artery coronary angioplasty显示文摘 | Stella PR Kiemeneij F Laarman G J | 1997 | Cathet Cardiovasc Diagn1997，40，2： | 1 |
| 12 | Incidebce and outcome of radia artery occlusion following transradial artery coronary angioplasty 显示文摘 | Stella PR Kiemeneij F Laarman GJ | 1997 | Cathet Cardiovasc Diagn1997，40，2： | 1 |
| 13 | Quasi-periodic oscillations in the X-ray flux of the rapid burster (MXB 1730-335)显示文摘 | STELLA L HABERL F LEWIN W H G | 1988 | The Astrophysical Journal1988，324，： | 1 |
| 14 | DAQNE broad-band button electrodes显示文摘 | MARCELLINI F SERIO M STELLA A | 1998 | Nuclear Instruments and Methods in Physics Research A1998，402，： | 1 |
| 15 | Endovascular treatment of common carotid artery dissection via the superficial temporal artery显示文摘 | Stella N Palombo G Filippi F | 2010 | J Endovasc Ther2010，17，4： | 1 |
| 16 | Cost-effective- ness of Implantable Cardioverter Defibrillators in Brazil in the Public and Private Sectors显示文摘 | Ribeiro R A Stella S F Zimerman L I | 2010 | Arq Bras Cardiol2010，95，5： | 1 |
| 17 | Encapsulation of gem- citabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules显示文摘 | Stella B Arpiceo S Rocco F | 2007 | Int J Pharm2007，344，12： | 1 |
| 18 | Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children 显示文摘 | Zhang F Li X Stella C | 2012 | J Pediatr2012，160，2： | 1 |
| 19 | Circulating plasma factors induce tubular and gomerular alterations in burn septic patients显示文摘 | Mariano F Cantaluppi V Stella M | 2008 | Crit Care2008，12，： | 1 |
| 20 | Pressure oscillations In solid rocket motors:Effect of nozzle cavity显示文摘 | F Stella F Paglia | | 0，，1： | 1 |
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