|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B virus and micro RNAs:Complex interactions affecting hepatitis B virus replication and hepatitis B virusassociated diseases显示文摘Chronic infection with the hepatitis B virus(HBV) is the leading risk factor for the development of hepatocellular carcinoma(HCC). With nearly 750000 deaths yearly, hepatocellular carcinoma is the second highest cause of cancer-related death in the world. Unfortunately, the molecular mechanisms that contribute to the development of HBV-associated HCC remain incompletely understood. Recently, micro RNAs(mi RNAs), a family of small non-coding RNAs that play a role primarily in post-transcriptional gene regulation, have been recognized as important regulators of cellular homeostasis, and altered regulation of mi RNA expression has been suggested to play a significant role in virus-associated diseases and the development of many cancers. With this in mind, many groups have begun to investigate the relationship between mi RNAs and HBV replication and HBV-associated disease. Multiple findings suggest that some mi RNAs, such as mi R-122, and mi R-125 and mi R-199 family members, are playing a role in HBV replication and HBV-associated disease, including the development of HBV-associated HCC. In this review, we discuss the current state of our understanding of the relationship between HBV and mi RNAs, including how HBV affects cellular mi RNAs, how these mi RNAs impact HBV replication, and the relationship between HBV-mediated mi RNA regulation and HCC development. We also address the impact of challenges in studying HBV, such as the lack of an effective model system for infectivity and a reliance on transformed cell lines, on our understanding of the relationship between HBV and mi RNAs, and proposepotential applications of mi RNA-related techniques that could enhance our understanding of the role mi RNAs play in HBV replication and HBV-associated disease, ultimately leading to new therapeutic options and improved patient outcomes. | Jason Lamontagne Laura F Steel Michael J Bouchard | 2015 | World Journal of Gastroenterology2015，21，24： | 17 |
| 2 | Mechanism of gold and silver species on activated carbon显示文摘 | Jia Y F Steele J Hayward P | 1998 | Carbon1998，36，9： | 1 |
| 3 | Current clinical immunother- apy targets in advanced nonsmall cell lung cancer(NSCLC)显示文摘 | McCarthy F Roshani R Steele J | 2013 | J Leukoc Biol2013，94，6： | 1 |
| 4 | Deficient cellular immunity in endometriosis 显示文摘 | Dmowski W P Steele R W Baker G F | 1981 | Am J Obstet Gynecol1981，141，4： | 1 |
| 5 | SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma显示文摘 | Schweqler E E Cazares L Steel L F | 2005 | Hepatology2005，41，3： | 1 |
| 6 | A new continuous catheter delivery system显示文摘 | STEELE S M KLEIN S M D'ERCOLE F J | 1998 | Anesth Analg1998，87，1： | 1 |
| 7 | Transcriptomic analysis reveals calcium regulation of specific promoter motifs in Arabidopsis 显示文摘 | Whalley H J Sargeant A W Steele J F | 2011 | Plant Cell2011，23，11： | 1 |
| 8 | Attenuation of pollutants in municipal landfill leachate by passage through clay显示文摘 | GRIFFIN R A SHIMP N F STEELE J D | 1976 | Environmental Science & Technology1976，10，13： | 1 |
| 9 | Combinatorial antibody libraries from survivors of the Turkish HSN1 avian influenza outbreak reveal virus neutralization strategies显示文摘 | Kashyap A K Steel J Ner A F | 2008 | Proc Natl Acad Sci U S A2008，105，16： | 1 |
| 10 | A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepantcellular carcinoma显示文摘 | Steel L F Shumpert D Trotter M | 2003 | Protiomics2003，3，5： | 1 |
| 11 | Metap lastic breast carcinomas are basal-like tumours显示文摘 | Reis-Filho JS Milanezi F Steele D | 2006 | Histopathology2006，49，1： | 1 |
| 12 | Cooling rate effect on outgrowth of Clostridium perfringens in cooked, ready-to-eat turkey breast roasts显示文摘 | STEELE F WRIGHT K | 2001 | Poultry Science2001，80，6： | 1 |
| 13 | Metaplastic breastcarcinomas are basal-like tumours显示文摘 | Reis-Filho JS Milanezi F Steele D | 2006 | Histopathology2006，49，1： | 1 |
| 14 | Biological nitrogen fixation in mixed legume/grass pastures显示文摘 | Ledgard S F and Steele K W | 1992 | Plant and Soil1992，141，： | 1 |
| 15 | Bayesian stochastic frontier a- nalysis using WinBUGS 显示文摘 | JIM E GRIFFIN MARK F J STEEL | 2007 | Journal of Productivity Analysis2007，27，5： | 1 |
| 16 | Comparison of 2 different regimens for reactogenicity, safety, and immunogenicity of the live attenuated oral rotavirus vaccine RIX4414 coadmi- nistered with oral polio vaccine in South African infants 显示文摘 | Steele AD Reynders J Schohz F et ol | 2010 | J Infect Dis2010，，： | 1 |
| 17 | Can 'negative' be positive显示文摘 | Steele F R | 2002 | Mol Ther2002，5，4： | 1 |
| 18 | Biological nitrogen fixation in mixed legume/grass pastures显示文摘 | Ledgard S F Steele K W | 1992 | Plant and Soil1992，141，： | 1 |
| 19 | The components of output growth : A stochastic frontier analysis 显示文摘 | Koop G Osiewalski J Steel M F J | 1999 | Ox- ford Bulletin of Economics and Statistics1999，61，4： | 1 |
| 20 | Heahh-related quality of life in patients with muhiple injuries and traumatic }rain injury 10+ years postinjury 显示文摘 | Steel J Youssef M Pfeifer f/ | 2010 | J Trauma2010，69，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员