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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Implications of preoperative hypoalbuminemia in colorectal surgery显示文摘Serum albumin has traditionally been used as a quantitative measure of a patient's nutritional status because of its availability and low cost. While malnutrition has a clear definition within both the American and European Societies for Parenteral and Enteral Nutrition clinical guidelines, individual surgeons often determine nutritional status anecdotally. Preoperative albumin level has been shown to be the best predictor of mortality after colorectal cancer surgery. Specifically in colorectal surgical patients, hypoalbuminemia significantly increases the length of hospital stay, rates of surgical site infections, enterocutaneous fistula risk, and deep vein thrombosis formation. The delay of surgical procedures to allow for preoperative correction of albumin levels in hypoalbuminemic patients has been shown to improve the morbidity and mortality in patients with severe nutritional risk. The importance of preoperative albumin levels and the patient's chronic inflammatory state on the postoperative morbidity and mortality has led to the development of a variety of surgical scoring systems to predict outcomes efficiently. This review attempts to provide a systematic overview of albumin and its role and implications in colorectal surgery. | Adam Truong Mark H Hanna Zhobin Moghadamyeghaneh Michael J Stamos | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 9 |
| 3 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 4 | A Tale of Two (Anal Fistula) Plugs: Is there a Difference in Short-Term Outcomes?显示文摘 | Buchberg Brian Masoomi Hossein Choi John Bergman Herlinda Mills Steven Stamos Michael J | 2010 | The American Surgeon2010，，10： | 2 |
| 5 | Extramedullary paraspinal hematopoiesis in thalassemia:CT and MRI evaluation显示文摘 | Tsitouridis J Stamos S Hassapopoulou E | 1999 | Eur J Radio1999，，30： | 1 |
| 6 | Management of early rectal T1 and T2 cancers 显示文摘 | Stamos M J Murrell Z | 2007 | Clin Cancer Res2007，13，222： | 1 |
| 7 | Exploiting Database Parallelism in A Message- passing Multiprocessor 显示文摘 | Lorie R A Daudenarde J Stamos J W | 1991 | IBM Journal of Research and Development1991，35，56： | 1 |
| 8 | Extr- ameduHary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation显示文摘 | Tsitouridis J Stamos S Hassapopoulou E | 1999 | Eur J Radiol1999，30，1： | 1 |
| 9 | The β - catenin destruction complex 显示文摘 | STAMOS J L WEIS W I | 2013 | Cold Spring Harb Perspect Biol2013，5，1： | 1 |
| 10 | Management of early rectal T1 and T2 cancers显示文摘 | Stamos M J Murrell Z | 2007 | Clin Cancer Res2007，13，22： | 1 |
| 11 | Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats显示文摘 | Thanos P K Tucci A Stamos J | 2010 | Behav Brain Res2010，215，1： | 1 |
| 12 | Management of early rectal T1 and T2 cancers 显示文摘 | Stamos M J Murrell Z | 2007 | Clin Cancer Res2007，13，22： | 1 |
| 13 | Crystal structure of the HGF beta - chain in complex with the Sema domain of the Met receptor显示文摘 | STAMOS J LAZARUS R A YAO X | 2004 | EMBO J2004，23，12： | 1 |
| 14 | Extramedullary paraspinal hematopoiesis in thalassemia:CT and MRI evaluation显示文摘 | Tsitouridis J Stamos S Hassapopoulou E | 1999 | Eur J Radiol1999，30，： | 1 |
| 15 | Extramedullary paraspinal hematopoiesis in thalassemia:CT and MRI evaluation显示文摘 | Tsitouridis J Stamos S nassapopoulou E | 1999 | Eur J Radiol1999，30，： | 1 |
| 16 | Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4- anilinoquinazoline inhibitor显示文摘 | Stamos J Sliwkowski MX Eigenbrot C | 2002 | Biol Chem2002，277，46： | 1 |
| 17 | The Sema domain of Met is necessary for receptor dimerization and activation显示文摘 | Kong-Beltran M Stamos J Wickramasinghe D | 2004 | Cancer Cell2004，6，1： | 1 |
| 18 | Extramedullary paraspinal hematopoiesis in thalaaaemia:CT and MRI evalution显示文摘 | Tsitouridis J Stamos S Hassapopoulou E | 1999 | Eur J Radial1999，30，1： | 1 |
| 19 | Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor显示文摘 | Stamos J Sliwkowski MX Eigenbrot C | | 0，，48： | 1 |
| 20 | Timely diagnosis of congenital infections 显示文摘 | Stamos J K | 1994 | Care of the Infant1994，41，5： | 1 |
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