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| 1 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 2 | Enhanced biodegradation of aromatic pollutants in cocultures of anaerobic and aerobic bacterial consortia 显示文摘 | FELDJ A STAMS A J M KATO M | 1995 | Antonievall Leeuwenhoek1995，67，： | 1 |
| 3 | Randomized,placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis显示文摘 | de Bruijn SF Stam J | 1999 | Stroke1999，30，3： | 1 |
| 4 | Randomized, placebo-controlled trial of antico- agulant treatment with low-molecular-wight heparin for cerebral sinus thrombosis显示文摘 | de Brujin SF Stam J | 1999 | Storke1999，30，： | 1 |
| 5 | Thrombosis of the cerebral veins and sinuses显示文摘 | Stam J | 2005 | N Engl J Med2005，352，17： | 1 |
| 6 | Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis:a prospective study显示文摘 | Stam J Majoie CB van Delden OM | | 0，，05： | 1 |
| 7 | Investigation of the dynamics underlying periodic complexes in the EEG显示文摘 | Stam CJ Vliegen JH Nicolai J | 1999 | Biol Cybern1999，80，： | 1 |
| 8 | Randomized,placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis显示文摘 | De Bruijn SF Stam J | 1999 | Stroke1999，30，3： | 1 |
| 9 | Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke显示文摘 | Immink RV Montfrans GA Stam J | 2005 | Stroke2005，36，12： | 1 |
| 10 | Thrombosis of the cerebral veins and sinuses显示文摘 | Stam J | | 0，，： | 1 |
| 11 | Analysis of end user securi- ty behaviors显示文摘 | Stanton J Stam K Mastrangelo P | 2005 | Computers & Security2005，24，2： | 1 |
| 12 | EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients 显示文摘 | Einh upl K Stam J Bousser MG | 2010 | Eur J Neurol2010，17，10： | 1 |
| 13 | Prognosis of cerebral vein and dural sinus thrombosis:results of the International Study on Cerebral Vein and Dural Sinus Thrombosis(ISCVT)显示文摘 | Ferro J M Canho P Stam J | 2004 | Stroke2004，35，3： | 1 |
| 14 | Small-world networks and function- al connectivity in Alzheimer' s disease 显示文摘 | Stam C J Jones BF | 2007 | Cereb Cortex2007，17，1： | 1 |
| 15 | Metabolic interactions between anaerobic bacteria in methanogenie environments 显示文摘 | Stams A J M | 1994 | Antonie Van Leeuwen hoek1994，66，： | 1 |
| 16 | Biogeography ofCladophoropsis membranacea (Chlorophyta) based on comparisons of nuclear rDNA ITS sequences 显示文摘 | Kooistra W H C F Stam W T Olsen J L | 1992 | Journal of Phycology1992，28，： | 1 |
| 17 | The Cerebral Venous Sinus Thrombosis Group Randomised placebo controlled trial of anticoagulant treatment with low molecular weight heparin for cerebral sinus thrombosis显示文摘 | DeBruijn SF Stam J | 1999 | Stroke1999，30，： | 1 |
| 18 | The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia显示文摘 | Hubeek I Stam RW Peter G J | 2005 | Br J Cancer2005，93，12： | 1 |
| 19 | Sugar-binding activity of pea lectin expressed in white clover hairy roots显示文摘 | Diaz C L Logman T J J Stam H C | | 0，，04： | 1 |
| 20 | Functional connectivity patterns of human magneto-encephalographic recordings: a small-worldnetwork显示文摘 | STAM C J | 2004 | Neuroscience LeUers2004，355，12： | 1 |
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