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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Simulations of the wind-forced near-surface circulation in Knight Inlet:A parameteriza- tion of the roughness length显示文摘 | STACEY M W | 1999 | J Phys Oceanogr1999，29，： | 1 |
| 3 | Nuclear and fuel cycle analysis for a fusion transmutation of waste reactor 显示文摘 | Hoffman E A Stacey W M | 2002 | Fusion Eng Design2002，6364，： | 1 |
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| 5 | Biodegradation of Rhamnolipid, EDTA and Citric Acid in Cadmium and Zinc Con- taminated Soils 显示文摘 | JIA W STACEY S P MCLAUGHLIN M J | 2009 | Soil Biology and Biochemistry2009，41，10： | 1 |
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| 8 | The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds 显示文摘 | Stacey M G Patel A McClain W E | 2008 | Plant Physiology2008，146，2： | 1 |
| 9 | The vertical structure of densityand tu rb id ity currents: Theory and observations 显示文摘 | Stacey M W Bowen A J | 1988 | Journalof Geophysical Research1988，93，4： | 1 |
| 10 | Binding of the steroidal pheromone 17α,20β-dihydroxy-4-pregnen-3-one to goldfish (Carassius auratus) olfactory epithelium membrane preparations 显示文摘 | Rosenblum P M Sorensen P W Stacey N E | 1991 | Chem Senses1991，16，14： | 1 |
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| 12 | The arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron todeveloping seeds显示文摘 | Stacey M G Patel A McClain W E | 2008 | Plant Physiology2008，146，： | 1 |
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| 14 | Cloning vectors for the expression of green fluorescent protein fusion proteins in transgenic plants显示文摘 | von Arnim A G Deng X W Stacey M G | 1998 | Gene1998，221，1： | 1 |
| 15 | Hormonal and pberomonal control of spawning behavior in the goldfish显示文摘 | Kobayashi M Sorensen P W Stacey N E | 2002 | Fish physiol Biochem2002，26，1： | 1 |
| 16 | A fusion transmutation of waste reactor 显示文摘 | Stacey W M Mandrekas J Hoffman E A | 2002 | Fusion Engineering and Design2002，6364，： | 1 |
| 17 | Dielectric characterization of costal cartilage chondrocytes显示文摘 | Stacey M W Sabuncu A C Beskok A | 2014 | Biochim Biophys Acta2014，1840，1： | 1 |
| 18 | Cloning vectors for the expression of green fluorescent protein fusion proteins in transgenicplants 显示文摘 | von Arnim A G Deng X W Stacey M G | 1998 | Gene1998，221，1： | 1 |
| 19 | A fusion transmutation of waste reactor 显示文摘 | STACEY W M MANDREKAS J HOFFNAM E | 2002 | Fusion Engineering and Design2002，63，1： | 1 |
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