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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Molecular signals exchanged between host plants and rhizobia: basic aspects and potential application in agriculture显示文摘 | HUNGRIA M STACEY G | 1997 | Soil Biology Biochemistry1997，29，： | 1 |
| 3 | Creation of residual flows in a partially stratified estuary 显示文摘 | Stacey M C Burau J R Monismith S G | 2001 | Journal of Geophysical Research2001，106，17： | 1 |
| 4 | Expression analyses of Arabidopsis oligopeptide transporters during seed germination, veg etative growth and reproduetion显示文摘 | STACEY M G OSAWA H PATEL A | 2006 | Planta2006，223，： | 1 |
| 5 | Cloning and functional characterization of a constitutively express-ed nitrate transporter gene,Osnrtl,from rice显示文摘 | LIN C M KOH S STACEY G | 2000 | Plant Physiology2000，122，2： | 1 |
| 6 | Genetics andfunctional genomics of legume nodulation显示文摘 | Stacey G Libault M Brechenmacher L | 2006 | Current Opinion inPlant Biology2006，9，2： | 1 |
| 7 | Expression analysis of Arabidopsis oligopeptide transporters during seed germina- tion, vegetative growth and reproduction 显示文摘 | Stacey M G Osawa H Patel A | 2006 | Planta2006，223，2： | 1 |
| 8 | Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma显示文摘 | Schmidt M Sun G Stacey M A | 2003 | J Immunol2003，171，1： | 1 |
| 9 | Genetics and functional genomics of legume nodulation显示文摘 | Stacey G Libault M Brechenmacher L | 2006 | Current Opinion in Plant Biology2006，9，2： | 1 |
| 10 | The condensation of long-chain fatty acids with polysaccharides and proteins 显示文摘 | Jones A S Kaye M A G Stacey M | 1952 | J Chem Soc1952，，： | 1 |
| 11 | The Seasat scanning multichannel microwave radiometer (SMMR): Instrument description and performance显示文摘 | Njoku E G Stacey J M Barath F | 1980 | IEEE Journal of Oceanic Engineering1980，5，2： | 1 |
| 12 | The p38 pathway provides negative feedback for Ras proliferarive signaling显示文摘 | Chen G Hitomi M Han J Stacey DW | 2000 | Bioll Chem2000，275，38： | 1 |
| 13 | Measurements of Reyn- olds stress profiles in unstratified tidal flow显示文摘 | Stacey M T Monismith S G Burau J R | 1999 | J Phys Oeeanogr1999，29，8： | 1 |
| 14 | Discrete domains mediate the lightresponsive nuclear and cytoplasmic localization of Arabidopsis COP1显示文摘 | Stacey M G Hicks S N Von Arnim A G | 1999 | Plant Cell1999，11，3： | 1 |
| 15 | Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells 显示文摘 | Sun G Stacey MA Schmidt M | 2001 | J Immunol2001，167，2： | 1 |
| 16 | Eotaxin expression and eosinophilic inflammation in asthma 显示文摘 | Mattoli S Stacey M A Sun G | 1997 | Biochem Biophys Res Commun1997，236，2： | 1 |
| 17 | The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds 显示文摘 | Stacey M G Patel A McClain W E | 2008 | Plant Physiology2008，146，2： | 1 |
| 18 | Identification of circulating fibrocytes as precursors of bronchial myofibro- blasts in asthma显示文摘 | Schmidt M Sun G Stacey MA | 2003 | J Immunol2003，171，1： | 1 |
| 19 | Identification of cir-culating fibrocytes as precursors of bronchial myofibroblastsin asthma显示文摘 | Schmidt M Sun G Stacey MA | 2003 | J Immunol2003，171，1： | 1 |
| 20 | Shoot to root communication is necessary to control the expression of ironacquisition genes in Strategy I plants 显示文摘 | Garcia M J Romera F J Stacey M G | 2012 | Planta2012，237，1： | 1 |
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