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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Performance of tunnel support under large deformation static and dynamic loading显示文摘 | ORTLEPP W D STACEY T R | 1998 | Tunnelling and Underground Space Technology1998，13，1： | 1 |
| 3 | The challenge of human interdependence显示文摘 | Stacey Ralph D | 2007 | European Business Review2007，19，4： | 1 |
| 4 | The dynamical and thermal structure of deep mantle plumes 显示文摘 | Loper D E Stacey F D | 1983 | Physics of the Earth and Planetary Interior1983，33，： | 1 |
| 5 | Frequency dependence of elasticity of rock--Test of seismic velocity dispersion显示文摘 | BRENNAN B J STACEY F D | 1977 | Nature1977，268，： | 1 |
| 6 | Surveying inventors listed on patents to investigate determinants of innova- tion 显示文摘 | Mattes E Stacey M C Marinova D | 2006 | Scientometrics2006，69，3： | 1 |
| 7 | Anelastic degradation of acoustic pulses in rocks显示文摘 | Gladwin M T Stacey F D | 1974 | Physics of the Earth and Planetary Interiors1974，8，4： | 1 |
| 8 | The emergence of knowledge in organizations 显示文摘 | Stacey R D | 2000 | Emergence2000，2，4： | 1 |
| 9 | Mechanical hysteresis in rocks at low strain amplitudes and seismic frequencies显示文摘 | Mckavanagh B Stacey F D | 1974 | Physics of Earth and Planet Interior1974，8，： | 1 |
| 10 | The Science of Complexity:An Alternative Perspective for Strategic Change Processes显示文摘 | Stacey Ralph D | 1995 | Strategic Management Journal1995，，16： | 1 |
| 11 | Two newly identified genetic determinants of pigmentation in Europeans显示文摘 | Sulem P Gudbjartsson D F Stacey S N | 2008 | Nature Genetics2008，40，7： | 1 |
| 12 | Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heine oxygenase, and cytochrome P-450 显示文摘 | Eaton D L Stacey N H Wong K L | 1980 | Toxicology and Applied Pharmacology1980，55，： | 1 |
| 13 | Frequency dependence of elasticity of rock-test of seismic velocity dispersion显示文摘 | Brennan B J Stacey F D | 1977 | Nature1977，268，： | 1 |
| 14 | Mechanical hysteresis in rocks at low strain amplitudes and seismic frequencies显示文摘 | MCKAVANAGH B STACEY F D | 1974 | Physics of the Earth and Planetary Interiors1974，8，3： | 1 |
| 15 | Mechanical hysteresis in rocks at low strain amplitudes and seismic frequencies 显示文摘 | Mckavanagh B Stacey F D | 1974 | Physics of the Earth and Planetary Interiors1974，8，3： | 1 |
| 16 | Performance of tunnel support under large deformation,static and dynamic loading显示文摘 | ORTLEPP W D STACEY T R | 1998 | Tunnelling and Underground Space Technology1998，13，1： | 1 |
| 17 | Rockburst mechanisms in tunnels and shafts 显示文摘 | Ortlepp W D Stacey T R | 1994 | Tunneling and Underground Space Technology1994，9，1： | 1 |
| 18 | Approximation of terrestrial lead i sotope evolution by a two-stage model显示文摘 | Stacey J S Kramers J D | 1975 | Earth and Planeta ry Science Letters1975，26，： | 1 |
| 19 | Approximation of terrestrial lead isotope evolution by a two-stage model显示文摘 | Stacey J S Kramers J D | 1975 | Earth and Planetary Science Letters1975，26，： | 1 |
| 20 | Genetic determinants of hair, eye and skin pigmentation in Europeans显示文摘 | Sulem P Gudbjartsson D F Stacey S N | 2007 | Nat Genet2007，39，： | 1 |
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