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	题名	作者	年代	出处	被引量
1	Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma显示文摘AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative treatment.METHODS Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with compensatedcirrhosis.Response to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance imaging.Eleven out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted nodules.RESULTS DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d mortality.The objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST respectively.Histological examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of cases.The overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis.	Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico	2017	World Journal of Radiology2017，9，5：	3
2	Semen characteristics and inflam- matory mediators in infertile men with different clinical diagnoses显示文摘	Moretti E Cosci I Spreafico A	2008	IntJ Androl2008，8，1：	1
3	Osteogenic growth peptide effects on primary human osteoblast cultures; potential relevance for the treatment of glucocorticoid-induced osteoporosis显示文摘	Spreafico A Frediani B Capperucci C	2006	J Cell Biochem2006，98，4：	1
4	Malignant peripheral nerve sheath tumors in children:a single-institution twenty-year experience显示文摘	Casanova M Ferrari A Spreafico F	1999	J Pediatr Hematol Oncol1999，21，6：	1
5	Malformations of cortical de- velopment 显示文摘	Arenica E Becker A J Spreafico R	2012	Brain Pathol2012，22，3：	1
6	Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes显示文摘	SPREAFICO A CHELLINI F FREDIANI B	2009	J Cell Biochem2009，108，5：	1
7	Malignant peripheral nerve sheath tumors in children;a singleinstitution twenty-year experience 显示文摘	Casanova M Ferrari A Spreafico F	1999	J Pediatr Hematol Oncol1999，21，6：	1
8	The prognostic and predic- tive role of histology in advanced non - small cell lung cancer:a lit- erature review 显示文摘	Hirsch FR Spreafico A Novello S	2008	J Thoracic Oncol2008，3，12：	1
9	Malignant renal tumours incidence and survival in European children ( 1978- 1997 ) : report from the Automated Childhood Cancer Information System project 显示文摘	Pastore G Znaor A Spreafico F	2006	Eur 3 Cancer2006，42，13：	1
10	Vinorelbine in previously treated advanced childhood sarcomas: evidence of activity in rhabdomyosarcoma 显示文摘	Casanova M Ferrari A Spreafico F	2002	Cancer2002，94，12：	1
11	Long-term effects of neridronate on human osteoblastic cell cultures显示文摘	Frediani B Spreafico A Capperucci C	2004	Bone2004，35，4：	1
12	Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis显示文摘	Spreafico A Frediani B Capperueci C	2006	J Cell Biochem2006，98，4：	1
13	Changes in plasmamass-spectral profile in course of treatment of non-small cell lungcancer patients with epidermal growth factor receptor tyrosinekinase inhibitors显示文摘	Lazzari C Spreafico A Bachi A	2012	J Thorac Oncol2012，7，1：	1
14	Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation显示文摘	Orlandini M Spreafico A Bardel i M		0，，26：	1
15	Prognostic value of circulating chromogranin A and soluble tumor necrosis factor recePtors in advanced nonsmaU cell lung cancer 显示文摘	Gregorc V SPreafico A Floriani I	2007	Cancer2007，110，4：	1
16	Osieogenic growth peptide effects on primary human osteoblast cuirass:potential relevance for the treatment of glucocorticoid-induced osteoporosis显示文摘	Spreafico A Frediani B Cappemcci C	2006	Cell Biochem2006，98，：	1
17	Malignant renal tumours in-cidence and survival in european children (1978 - 1997) : Reportfrom the automated childhood cancer information system project显示文摘	Pastore G Znaor A Spreafico F	2006	Eur J Cancer2006，42，13：	1
18	A proteomic study on human osteoblastic cells proliferation and differentiation显示文摘	Spreafico A Frediani B Capperucci C		0，，12：	1
19	Antiproliferative and proapoptotic activities of new pyrazolo pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells显示文摘	Spreafico A Schenone S Serchi T	2008	FASEB J2008，22，5：	1
20	Malignant renal tumours incidenceand survival in European children( 1978 - 1997 ) :Report from the Auto- mated Childhood Cancer Information System project 显示文摘	Pastore G Znaor A Spreafico F	2006	Eur J Cancer2006，42，13：	1

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