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| 1 | 肥厚型心肌病猝死危险因素分层显示文摘肥厚型心肌病(HCM)是最常见的遗传性心脏病。普通人群患病率1/500,以自然病史差异极大为特征。很多患者终生无症状,寿命与常人并无不同。有些患者有心力衰竭(心衰)或心房颤动(房颤)的症状,某些患者猝死。猝死者常常先前没有症状,年龄较轻。HCM是青年人和运动员最常见的猝死原因。因此对猝死危险进行分层,预防猝死是一个重要的临床问题。 | Paolo Spirito Barry J Maron | 2009 | 中华心血管病杂志2009，37，4： | 12 |
| 2 | Efficacy and safety of low-intensity shockwave therapy plus tadalafil 5 mg once daily in men with type 2 diabetes mellitus and erectile dysfunction:a matched-pair comparison study显示文摘Low-intensity extracorporeal shockwave therapy(LiESWT)represents a promising treatment for patients with erectile dysfunction(ED).We investigated the efficacy of LiESWT combined with tadalafil 5 mg once daily in men with type 2 diabetes mellitus(T2DM)and ED and compared LiESWT protocols administering different number of shockwaves.We performed a retrospective matched-pair comparison using data from a prospectively maintained database.Seventy-eight patients who received tadalafil 5 mg once dai7ly for 12 weeks+LiESWT performed with an electrohydraulic source for 3 weeks(Group A)were matched 1:1 to patients who received tadalafil 5 mg once daily alone for 12 weeks(Group B).A subgroup analysis was performed according to the number of shockwaves delivered during each session(1500,1800,and 2400 in subgroup A1,A2,and A3,respectively).The mean International Index of Erectile Function-5(IIEF-5)score variations with respect to baseline recorded at 4,12,and 24 weeks after the end of the treatment were investigated as treatment outcomes.The mean IIEF-5 scores significantly improved in all groups and subgroups at 4-week follow-up without intergroup differences.At 12-and 24-week follow-up,the mean IIEF-5 improvement was significantly higher among patients in the A3 subgroup(+5.0±2.1[P<0.001]and+4.7±2.3[P<0.001],respectively).The combined approach with tadalafil 5 mg once daily and LiESWT with a protocol involving 2400 shockwaves provides significant advantages in terms of IIEF-5 improvement and durability compared to tadalafil 5 mg once daily alone in patients with T2DM and ED. | Paolo Verze Marco Capece Massimiliano Creta Roberto La Rocca Francesco Persico Lorenzo Spirito Antonio Cardi Vincenzo Mirone | 2020 | Asian Journal of Andrology2020，22，4： | 8 |
| 3 | 肥厚型心肌病猝死预防:肥厚型心肌病患者除颤器置入显示文摘从50年前认识到肥厚型心肌病(HCM)起,对HCM患者猝死危险已有了充分的认识和足够的重视。HCM是青年人(包括受训运动员)猝死最常见的原因。置入性心脏除颤器(ICD)起初用于治疗缺血性心脏病,近几年用于HCM心原性猝死的预防。临床ICD置人增加很快,是改变HCM青年患者病程的主要治疗手段。 | Barry J Maron Paolo Spirito | 2009 | 中华心血管病杂志2009，37，4： | 4 |
| 4 | Changes in cellular mechanical properties during onset or progression of colorectal cancer显示文摘Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC. | Gabriele Ciasca Massimiliano Papi Eleonora Minelli Valentina Palmieri Marco De Spirito | 2016 | World Journal of Gastroenterology2016，22，32： | 3 |
| 5 | ICD预防肥厚型心肌病患者发生心脏性猝死的研究显示文摘背景:ICD最近被用于预防肥厚型心肌病(HCM)患者发生心脏性猝死,但是,对其疗效以及患者的选择仍未完全明确。目的:研究HCM患者的临床危险因素状况与ICD植入的发生率及有效性。设计、地点和患者:1986—2003年,入选506例相互无关的HCM患者。 | Maron B.J. Spirito P. 吴超能 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 2 |
| 6 | Controlling the Cassie-to-Wenzel Transition: an Easy Route towards the Realization of Tridimensional Arrays of Biological Objects显示文摘In this paper we provide evidence that the Cassie-to-Wenzel transition, despite its detrimental effects on the wetting properties of superhydrophobic surfaces, can be exploited as an effective micro-fabrication strategy to obtain highly ordered arrays of biological objects. To this purpose we fabricated a patterned surface wetted in the Cassie state, where we deposited a droplet containing genomic DNA. We observed that, when the droplet wets the surface in the Cassie state, an array of DNA filaments pinned on the top edges between pillars is formed. Conversely, when the Cassie-to-Wenzel transition occurs, DNA can be pinned at different height between pillars. These results open the way to the realization of tridimensional arrays of biological objects. | G.Ciasca M.Papi M.Chiarpotto A.De Ninno E.Giovine G.Campi A.Gerardino M.De Spirito L.Businaro | 2014 | Nano-Micro Letters2014，6，3： | 2 |
| 7 | On the accuracy of cellular mobile station location estimation显示文摘 | Spirito M A | 2001 | 1EEE Transactions on Vehicle Technology2001，50，5： | 1 |
| 8 | Sudden death and hypertrophic cardiomyopathy显示文摘 | Spirito P Maron BJ | 2001 | Lancet2001，357，9272： | 1 |
| 9 | Usefulness of Dopple echocardiographic assessment of diastolic filling in distinguishing “athlete,heart” from hypertrophic cardiomyopathy显示文摘 | Lewis JF Spirito P Pelliccia A | 1992 | Br Heart J1992，68，3： | 1 |
| 10 | The use of scheduled awakenings to eliminate childhood sleepwalking 显示文摘 | Frank NC Spirito A Stark L | 1997 | J Pediatr Psychol1997，22，3： | 1 |
| 11 | Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy显示文摘 | Spirito P Bellone P Harris KM | 2000 | N Engl J Med2000，342，24： | 1 |
| 12 | Evidence for a proin flammatory and proteolytic environment in plaques from endarterectomy segments of human carotid arteries显示文摘 | Formato M Farina M Spirito R | 2004 | Arterioseler Thromb Vasc Bioi2004，24，： | 1 |
| 13 | Evidence for a proinflammatory and proteolytie environment in plaques from endarterectomy segments of human carotid arteries 显示文摘 | Formato M Farina M Spirito R | 2004 | Arterioseler Thromb Vasc Biol2004，24，1： | 1 |
| 14 | The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer:a debated therapeutic option显示文摘 | Gadducci A Spirito N Baroni E | 2009 | Gynecol Endocrinol2009，25，10： | 1 |
| 15 | The Children' s Sleep Habits Questionnaire(CSHQ) : psychometric properties of a survey instru- ment for school-aged children 显示文摘 | Owens JA Spirito A MeGuinn M | 2000 | Sleep2000，8，23： | 1 |
| 16 | A preoperative index of mortality for patients undergoing surgery of type A aortic dissection显示文摘 | SPIRITO R POMPILIO G ALAMANNI F | 2001 | J Cardiovasc Surg (Torino)2001，42，4： | 1 |
| 17 | Quantitative assessment of ultrasonic myocardial reflectivity in hyperteopic cardiomyopathy显示文摘 | Lattanzi F Spirito P Picano E | 1991 | J Am Coll Cardiol1991，17，： | 1 |
| 18 | The management of hypertrophic cardiomyopathy显示文摘 | Spirito P Seidman CE McKenna WJ | 1997 | N Engl J Med1997，336，： | 1 |
| 19 | Affective,behavioral,and cognitive functioning in adolescents with multiple suicide attempts显示文摘 | Esposito C Spirito A Boergers J | 2003 | Suicide Life Threat Behav2003，33，4： | 1 |
| 20 | Cooperative spectrum sensing based on the limiting eigenvalue ratio distribution in Wishart matrices显示文摘 | PENNA F GARELLO R SPIRITO M A | | 0，，07： | 1 |
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