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| 1 | How to identify which patients with asymptomatic carotid stenosis could benefit from endarterectomy or stenting显示文摘Offering routine carotid endarterectomy(CEA)or carotid artery stenting(CAS)to patients with asymptomatic carotid artery stenosis(ACS)is no longer considered as the optimal management of these patients.Equally suboptimal,however,is the policy of offering only best medical treatment(BMT)to all patients with ACS and not considering any of them for prophylactic CEA.In the last few years,there have been many studies aiming to identify reliable predictors of future cerebrovascular events that would allow the identification of patients with high-risk ACS and offer a prophylactic carotid intervention only to these patients to prevent them from becoming symptomatic.All patients with ACS should receive BMT.The present article will summarise the evidence suggesting ways to identify these high-risk asymptomatic individuals,namely:(1)microemboli detection on transcranial Doppler,(2)plaque echolucency on Duplex ultrasound,(3)progression in the severity of ACS,(4)silent embolic infarcts on brain CT/MRI,(5)reduced cerebrovascular reserve,(6)increased size of juxtaluminal hypoechoic area,(7)identification of intraplaque haemorrhage using MRI and(8)carotid ulceration.The evidence suggests that approximately 10%-15%of patents with asymptomatic stenosis might benefit from intervention;this will become more clear after publication of ongoing studies comparing stenting or endarterectomy with best medical therapy.In the meantime,no patient should be offered intervention unless there is evidence of high risk of ipsilateral stroke,from modalities such as those discussed here. | Kosmas I Paraskevas Frank J Veith J David Spence | 2018 | Stroke & Vascular Neurology2018，3，2： | 10 |
| 2 | An Overview of Flood Actions on Buildings 显示文摘 | Kelman I Spence R | 2004 | Eng Geol2004，73，： | 1 |
| 3 | Exercise and vascu- lar adaptation in asymptomatic humans显示文摘 | GREEN I) J SPENCE A HALLIWILL J R | 2011 | Experimental physiology2011，96，2： | 1 |
| 4 | Three-Dimension Finite Modeling of Ring Rolling显示文摘 | Hu Z M Pillinger I Hartley P MeKenzie S Spence P J | 1994 | Journal of Materials Processing Technology1994，45，： | 1 |
| 5 | The Galerkin method for integral equations of the first kind with loga- rithmic kernel: theorem显示文摘 | Sloan I H Spence A | 1988 | IMA J Numer Anal1988，8，1： | 1 |
| 6 | Reduced magnetization produced by increased methane flux at a gas hydrate vent显示文摘 | Novosel I Spence G D Hyndman R D | 2005 | Marine Geology2005，216，： | 1 |
| 7 | Video games and spatial cognition显示文摘 | Spence I Feng J | | 0，，02： | 1 |
| 8 | A neurotoxin of no- vel structural type from the venom of the australian com- mon brown snake显示文摘 | Barnett D Howden M E H Spence I | 1980 | Die Naturwissenschaften1980，67，8： | 1 |
| 9 | Normal perfusion pressure breakthrough:the role of capillaries显示文摘 | Sekhon LH Morgan MK Spence I | 1997 | J Neurosurg1997，86，3： | 1 |
| 10 | Be havioural and functional anatomical correlates of de ception in humans 显示文摘 | Spence S A Farrow I F Herford A E | 2001 | Neuroreport2001，12，13： | 1 |
| 11 | Dietary intervention to revers carotid atherosclerosis 显示文摘 | SHAI I SPENCE JD SCHWARZFUCHS D | 2010 | Circulation2010，121，10： | 1 |
| 12 | The roles of me- latonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders显示文摘 | Pandi-Perumal SR Trakht I Spence DW | 2008 | Nat Clin Pract Neurol2008，4，8： | 1 |
| 13 | Geophysical and geochemical signatures associated with gas hydrate related venting in the northern Cascadia margin显示文摘 | Riedel M Novosel I Spence G D | 2006 | GSA Bulletin2006，118，： | 1 |
| 14 | Geophysical and geochemical signatures associated with gas hydrate-related venting in the northern Cascadia margin显示文摘 | Riedel M Novosel I Spence G D | 2006 | Geological Society of America Bulletin2006，118，12： | 1 |
| 15 | Dietary intervention to reverse carotid atherosclerosis 显示文摘 | Shai I Spence JD Schwarzfuchs D | 2010 | Circulation2010，121，10： | 1 |
| 16 | Dietary intervention to reverse carotid atherosclerosis显示文摘 | Shai I Spence JD Schwarzfuchs D | | 0，，10： | 1 |
| 17 | Playing an action video game reduces gender difference in spatial cognition 显示文摘 | Feng J Spence I Pratt J | 2007 | Psychol Sci2007，18，10： | 1 |
| 18 | Munochemotherapy of bladder carcinoma with glucan and clophosphamide显示文摘 | Thompson I M Spence CR Lamm DL | 1987 | AmJ Med Sci1987，294，5： | 1 |
| 19 | Dietary intervention to revers carotid atheroselernsis 显示文摘 | Shai I Spence JD Sehwarzfuchs D | 2010 | Circulation2010，121，10： | 1 |
| 20 | Normal perfusion breakthrough :the roles of capillaries 显示文摘 | Sekhon LHS Morgan MK Spence I | 1997 | J Neurosurg1997，86，： | 1 |
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