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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020,19,5: | 6 |
| 2 | A role for the AKT1 potassium channel in plant nutrition显示文摘 | Hirsch R E Lewis B D Spalding E P | 1998 | Science1998,280,: | 1 |
| 3 | Occurrence of Nitrate in Groundwa- ter: A Review 显示文摘 | SPALDING R F EXNER M E | 1993 | Journal of Environmental Quality1993,22,: | 1 |
| 4 | Effects of artificial, recharge on ground water quality and aquifer storage reeovery 显示文摘 | Ma L Spalding R F | 1997 | Journal of the American Water Resources Association1997,33,3: | 1 |
| 5 | Controlling nitrate leaching in irrigated agriculture显示文摘 | Spalding R F Watts D G Schepers J S | 2001 | Journal of Environmental Quality2001,30,: | 1 |
| 6 | Source identification of nitrate on Cheju Island, South Korea 显示文摘 | Spalding R F U Z K Hyun S W | 2001 | Nutrient Cycling in Agroecosystems2001,61,3: | 1 |
| 7 | Aquifer denitrification as interpreted from in situ microcosm experiments显示文摘 | BATES H K SPALDING R F | 1998 | J Environ Qual1998,27,: | 1 |
| 8 | Complementary and alternative medicine use among primary care patients in west Texas显示文摘 | Zhang Y Jones B Ragain M Spalding M Mannschreck D Young R | 2008 | South MedJ2008,101,12: | 1 |
| 9 | A role for the AKT1 potassium channel in plant nutrition 显示文摘 | HIRSCII R E LEWIS B D SPALDING E P el al | 1998 | Science1998,280,5365: | 1 |
| 10 | Three-dimensional and thermal surface imaging produces reliable measures of joint shape and temperature:a potential tool for quantifying arthritis显示文摘 | Spalding SJ Kwoh CK Boudreau R | 2008 | Arthritis Res Ther2008,10,1: | 1 |
| 11 | A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes 显示文摘 | Margolls R Spalde RF | 2009 | Am J OphOzcdmol2009,147,6: | 1 |
| 12 | The formation of dimensionally ordered germanium nanowires within mesoporous silica显示文摘 | Coleman N R B Ryan K M Spalding T R | 2001 | Chem Phys Lett2001,343,: | 1 |
| 13 | Occurrence of nitrate in groundwater-a review 显示文摘 | Spalding R F Exner M E | 1993 | Journal of Environmental Quality1993,22,3: | 1 |
| 14 | Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL显示文摘 | Gibson S B Oyer R Spalding AC | 2000 | Mol Cell Biol2000,20,1: | 1 |
| 15 | A two equation model of turbulence and its application to heated plane jets and wakes显示文摘 | Malin M R Spalding D B | 1984 | Physieoehemical Hydrodynamics1984,5,: | 1 |
| 16 | Nitrogen isotope indicators of seasonal source variability to groundwater显示文摘 | Iqbal M Z Krothe N C Spalding R F | 1997 | Environmental Geology1997,32,3: | 1 |
| 17 | Occurrence of nitrate in groundwa- ter a re view显示文摘 | SPALDING R EXNER M E | 1993 | Environ Qual1993,22,: | 1 |
| 18 | Pancreatic and periampullary cancers:treatment and outcome显示文摘 | Spalding D R | 2006 | Br J Hosp Med(Lond)2006,67,1: | 1 |
| 19 | Occurrence of nitrate in groundwater-A review显示文摘 | Spalding R F Exner M E | 1993 | Journal of Environmental Quality1993,22,3: | 1 |
| 20 | Controlling Nitrate Leaching in Irrigated Agriculture显示文摘 | SPALDING R F WALTTS D G SCHEPERS J S | 2001 | Journal of Environmental Quality2001,30,78: | 1 |