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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines显示文摘 | Jácomo R H Melo R A Souto F R | 2007 | Haematologica2007，92，10： | 1 |
| 3 | Simulation of anti-roll tanks and sloshing type problems with Smoothed Particle Hydrodynamics 显示文摘 | Souto Iglesias A | 2004 | Ocean Engineering2004，31，： | 1 |
| 4 | On the existence and con- centration behaviour of ground state solutions for a class of problems with critical growth 显示文摘 | Alves C O Souto M A S | 2002 | Comm Pure Appl Anal2002，3，： | 1 |
| 5 | Dyeing mechanism and optimization of polyamide 6,6 functionalized with double barrier discharge (DBD) plasma in air显示文摘 | Oliveira F R Zille A Souto A P | 2014 | Applied Sur- face Science2014，293，： | 1 |
| 6 | Liquid moment amplitude assessment in sloshing type problems with Smooth Paritcle Hydrodynamics显示文摘 | Souto Iglesias A | 2006 | Ocean Eengineering2006，33，： | 1 |
| 7 | Prevalence of Enterococcus faecalis in subgingival biofilm and saliva of subjects with chronic periodontal infection显示文摘 | Souto R Colombo A P | | 0，，2： | 1 |
| 8 | On systems of elliptic equations involving subcritical or critical Sobolev exponents显示文摘 | Alves C O Filho D C de M Souto M A S | 2000 | Nonlinear Analysis2000，42，： | 1 |
| 9 | A doubleline sequential injection system for the spectrophotometric determination of copper, iron, manganese, and zinc in waters 显示文摘 | Morais I P Souto M R Rangel A O | 2002 | Anal Bioanal Chem2002，373，12： | 1 |
| 10 | Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery 显示文摘 | SOUTO E B WISSING S A BARBOSA C M | 2004 | Int J Pharm2004，278，1： | 1 |
| 11 | Clinical features and outcomes of 134 Brazilians with acute promyelocytie leukemia who received ATRA and anthracyclines 显示文摘 | JACOMO R H MELO R A SOUTO F R | 2007 | Haematologica2007，92，10： | 1 |
| 12 | Spectrophoto- metric flow system using vanadomolybdophosphate detection chemistry and a liquid waveguide capillary cell for the determination of phosphate with improved sensitivity in surface and ground water samples显示文摘 | Neves M S A C Souto M R S | 2008 | Talanta2008，77，： | 1 |
| 13 | Adenocarcinoma of the cardia:does it arise in Barrett epithelium 显示文摘 | Souto E 0 Cameron A J Olivira A M | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 14 | Superlinear problems without Ambrosetti and Rabinowitz growth condition显示文摘 | MIYAGAKI O H SOUTO M A S | 2008 | Journal of Dif- ferential Equations2008，245，12： | 1 |
| 15 | Multi-resolution broadcast/multicast systems for MBMS显示文摘 | Correia A Silva J and Souto N | 2007 | IEEE Transactions on Broadcasting2007，53，1： | 1 |
| 16 | Development of single- crystal c -A1203 fibers by vapor-liquid-solid deposition (VLS) from aluminum and powdered silica 显示文摘 | VALCA'RCEL V SOUTO A GUITIArN F | 1998 | Adv Mater1998，，10： | 1 |
| 17 | Solid lipid nanoparticles as a drug delivery system for peptides and proteins 显示文摘 | Almeida A J Souto E | 2007 | Adv Drug Deliv Rev2007，59，6： | 1 |
| 18 | In situ monitoring of electroactive species by using the scanning electrochemical microscope. Application to the investigation of degradation processes at defective coated metals显示文摘 | R.M. Souto Y. González-Garc??a S. González | 2005 | Corrosion Science2005，，12： | 1 |
| 19 | Solid lipid nanoparticles as a drug delivery system for peptides and proteins 显示文摘 | Almeida A J Souto E | 2007 | Adv Drug Deliv Rev2007，59，： | 1 |
| 20 | Evaluation of the physical stability of SLN and NLC before and after incor-poration into hydrogel formulations 显示文摘 | Souto E B Wissing S A Barbosa C M | 2004 | Eur J Pharm Biopharm2004，58，1： | 1 |
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