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| 1 | Statistical design and evaluation of a propranolol HCl gastric floating tablet显示文摘The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state. | Meka Venkata Srikanth Nali Sreenivasa Rao Songa Ambedkar Sunil Battu Janaki Ram Venkata Ramana Murthy Kolapalli | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 6 |
| 2 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
| 3 | Optimization of microstructures and magnetic properties of Sm(Co_(bal)Fe_(0.227)Cu_(0.07)Zr_(0.023))_(7.6) magnets by sintering treatment显示文摘Magnetic properties and microstructures of Sm(Co_(bal)Fe_(0.227)Cu_(0.07)Zr_(0.023_)_(7.6) sintered magnets were optimized by sintering treatment. Results show that the knee-point magnetic field, Hknee, is twofold up and the intrinsic coercivity Hcjincreases by 40%, ranging from 21.64 to 30.39 kOe at the cost of a little decrease of Brfrom 10.84 to 10.31 kGs with sintering temperature decreasing from 1488 to 1473 K. And the average domain width is narrower and more uniform for the specimen sintered at 1473 K than that of the specimen sintered at 1488 K. It is impressive that the density of lamellar phase increases from ~0.050 to ~0.058 nm^(-1) with the sintering temperature decreasing from 1488 to 1473 K. Moreover, the average cellular size is about ~84 nm for the magnets sintered at 1473 K, which is 80% of that of the magnets sintered at 1488 K(~97 nm). And the cell boundary width of the magnets sintered at 1473 K(~7 nm) is only half average width of the magnets sintered at 1488 K(~14 nm). It is found that the Cu content in the cell boundaries is much higher(~17 at%) in the magnets sintered at 1473 K compared to that of the magnets sintered at 1488 K(~10 at%). It can be concluded that smaller cells and narrower cell boundaries together with higher gradient of Cu content are key points for obtaining the optimum Hkneeand Hcj. | Kuikui Songa Wei Suna Yikun Fang Shuai Wang Nengjun Yu Meiling Zhang Minggang Zhu Wei Li | 2019 | Journal of Rare Earths2019，37，2： | 6 |
| 4 | Precolumn derivatization LC-MS/MS method for the determination and pharmacokinetic study of glucosamine in human plasma and urine显示文摘A selective precolumn derivatization liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of glucosamine in human plasma and urine has been developed and validated. Glucosamine was derivatized by o-phthalaldehyde/3-mercaptopropionic acid. Chromatographic separation was performed on a Phenomenex ODS column (150 mm 4.6 mm, 5 mm) using linear gradient elution by a mobile phase consisting of methanol (A), and an aqueous solution containing 0.2% ammonium acetate and 0.1% formic acid (B) at a flow rate of 1 mL/min. Tolterodine tartrate was used as the internal standard (IS). With protein precipitation by acetonitrile and then the simple one-step derivatization, a sensitive bio-assay was achieved with the lower limit of quantitation (LLOQ) as low as 12 ng/mL for plasma. The standard addition calibration curves suitable for clinical sample analysis showed good linearity over the range of 0.012-8.27 mg/mL in plasma and 1.80-84.1 mg/mL in urine. The fully validated method has been successfully applied to a pharmacokinetic study of compound glucosamine sulfate dispersible tablets in health Chinese volunteers receiving single oral doses at 500, 1000 and 1500 mg of glucosamine sulfate, as well as multiple oral doses of 500 mg t.i.d. for 7 consecutive days. | Min Songa, Tai-Jun Hanga, Cheng Wanga, Lin Yangb, Ai-Dong Wenb aDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China bDepartment of Pharmacy, Xijing Hospital, Xi’an 710032, China | 2012 | Journal of Pharmaceutical Analysis2012，2，1： | 3 |
| 5 | Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study显示文摘A sensitive and specific liquid-chromatography tandem mass spectrometry(LC-MS/MS)assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine.The assay employed a single liquid–liquid extraction of the analytes from plasma and urine samples,and diazepam was used as internal standard(IS).The chromatographic separation was achieved on a Diamonsil C18 column(150 mm4.6 mm,5 mm,Dikma)using a mixture of methanol and aqueous 5 mM ammonium acetate buffer containing 0.2%formic acid(80:20,v/v)as mobile phase.The assay for ivabradine and N-desmethylivabradine in plasma showed good linearity(r≥0.99)over the ranges 0.1013–101.3 ng/mL and 0.085–25.5 ng/mL,respectively.The assay for ivabradine and N-desmethylivabradine in urine showed good linearity(r≥0.99)over the ranges 10.13–6078 ng/mL and 8.5–850 ng/mL,respectively.The intra-and inter-day accuracy and precision values were found to be within the assay variability limits(RSD<15%)in accordance with FDA guidelines.The methods were successfully used for evaluating the pharmacokinetic properties of ivabradine and N-desmethylivabradine in human plasma and urine in Chinese healthy volunteers. | Chengtao Lu Yanyan Jia Jing Yang Xin Jin Ying Songa Wenxing Liu Yi Ding Xiaoli Sun Aidong Wen | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 3 |
| 6 | Penetration in vitro of zona- free pig oocytes by homologous and heterologous spermatozoa 显示文摘 | Zhao X M Songa X X Kawai Y | 2002 | Theriogenology2002，58，5： | 1 |
| 7 | Defining maritime lo- gistics hub and its implication for container port 显示文摘 | Hyung-Sik Nama Dong-Wook Songa | 2011 | Maritime Policy & Management: The flagship journal of international shipping and port research2011，38，3： | 1 |
| 8 | Use of blind placements of peripherally inserted central catheters in burn patients: A retrospective analysis显示文摘 | Younghwan Choia Changmin Songa Eunok Parka | 2015 | Burns2015，41，： | 1 |
| 9 | Biological evaluationof anti-influenza viral activity of semi-synthetic catechinderivatives显示文摘 | Songa JM Parka KD Lee KH | 2007 | Antiviral Research2007，76，2： | 1 |
| 10 | Synthesis of methane gas hydrate in porous sediments and its dissociation by depressurizing 显示文摘 | Hisashi O Kono Sridhar Narasimhan Feng Songa | 2002 | Powder Technology2002，122，2： | 1 |
| 11 | Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats显示文摘 | Xiu-Yun Songa Jin-Feng Hub Shi-Feng Chua | 2013 | Eur J Pharmaco12013，710，15： | 1 |
| 12 | Study on the relationship between the structure and activities of alkyl methacrylate-maleican hydride polymers as cold flow improvers in diesel fules 显示文摘 | Songa Y | 2005 | Fuel Processing Technology2005，86，6： | 1 |
| 13 | Mirror finishing of Co-Cr-Mo alloy using elliptical vibration cutting显示文摘 | SONGA Yong-chang Criun-heng P Toshimichi M | | 0，，04： | 1 |
| 14 | Immunomodulation and antitumor activity of k-carrageenan oligosaccharides 显示文摘 | Huamao Yuana Jinming Songa Xuegang Lia | 2006 | Cancer Letters2006，243，： | 1 |
| 15 | Corporate Governance and Market Valuation in China显示文摘 | Bai C Liua Q Lua J Songa F M Zhang J | 2004 | Journal of Com- parative Economics2004，32，4： | 1 |
| 16 | Electrochemical detection of glyphosate herbicide using horseradish peroxidase immobilized on su|fonated polymer matrix 显示文摘 | SONGA E A AROTIBA O A OWINO J H | 2009 | Bioelectrochemistry2009，75，2： | 1 |
| 17 | Mining Pareto-optimal modules for delayed product differentiation显示文摘 | SONGA Z KUSIAK A | | 0，，01： | 1 |
| 18 | Antiangiogenic,antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus显示文摘 | Yun Seon Songa Sun-Hyoung Kimb Jae-Hoon Sa c | 2003 | Journal of Ethnopharmacology2003，88，1： | 1 |
| 19 | Hierarchical microstructure of explosive joints:Example of titanium to steel cladding显示文摘 | Songa J Kostkaa A Veehmayerb M | | 0，，： | 1 |
| 20 | Fusibility and flow properties of coal ash and slag显示文摘 | Wenjia Songa Lihua Tanga Xuedong Zhu | 2009 | Fuel2009，88，： | 1 |
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