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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 浸渍硅胶薄层色谱板分离钴和镍及数字图像分析法定量(英文)显示文摘Thin layer chromatography(TLC) of cobalt and nickel has been performed on silica gel layers induced with alkali mediated cellulose extract.A novel combination of 10% aqueous solutions of Tween-20 and potassium thiocyanate in 1∶1(v/v) was identified as the best mobile phase for the selective separation of Co2+from Ni2+on the impregnated Silica Gel G layers.The chromatographic characteristics of the cations were studied and the limits of detection as well as the limits of quantification for Co2+and Ni2+were determined.The quantitative estimation of the cations was achieved from the digital image analysis of respective chromatograms.The proposed quantitative method was successfully applied with 0-0.50% error for the determination of Co2+from Ni2+in spiked samples of bauxite,soil and rock containing common cations such as Al3+,Fe2+,Ti4+,Zn2+,Mn2+,Cu2+,Cr6+,Mg2+,etc.under the optimized chromatographic conditions. | P A MOHAMED NAJAR R G SONALI M T NIMJE K V RAMANA RAO | 2012 | 色谱2012，30，10： | 2 |
| 3 | Vascular endothelial growthfactor immunoneutralization in combinationwith cisplatin reduces EAC tumor growth显示文摘 | SONALI G PUTUL M | 2006 | Int Immunopharmacol2006，6，10： | 1 |
| 4 | Bromelain Limits Airway Inflammation in an Ovalbumin-induced Murine Model of Established Asthma显示文摘 | Secor Eric R Shah Sonali J Guernsey Linda A Schramm Craig M Thrall Roger S | 2012 | EN2012，，5： | 1 |
| 5 | Val66Met polymorphism and BDNF levels in Alzheimer’s disease patients in North Indian population显示文摘 | Sonali N Tripathi M Sagar R | 2013 | Int J Neurosci2013，123，6： | 1 |
| 6 | Metabolic sta- bility of plants regenerated from cryopreserved shoot tips of Dioscorea deltoidea Science Horticulturae an endangered medicinal plant显示文摘 | Sonali D S Sangeeta A G Binay B M | 2005 | Scientia Horticulturae2005，105，： | 1 |
| 7 | Molecular, pheno- typic and biosynthetic stability in Dioscorea floribunda plants derived from cryopreserved shoot tips显示文摘 | Sangeeta A Binay B M Sonali D | 2002 | plant sci- ence2002，163，： | 1 |
| 8 | Alkaline phytase from Lilium longiflorum:Purification and structural characterization显示文摘 | Barry G G Sonali P J Bakul D M | 2006 | Protein expression and purification2006，46，2： | 1 |
| 9 | Insight into the salt tolerance factors of a wild halophytic rice, Porteresia coarctata:a physiological and proteomic approach 显示文摘 | Sonali S Arun L M | 2009 | Planta2009，229，： | 1 |
| 10 | Extracellular biosynthesis andcharacterization of silver nanoparticles using Aspergillus flavus NJP08:Amechanism perspective显示文摘 | NAVIN J ARPIT B SONALI M | 2011 | Nanoscale2011，3，： | 1 |
| 11 | Alkaline phytase from Lilium longiflorum: Purification and structural characterization显示文摘 | Barry G Garchow Sonali P Jog Bakul Dhagat Mehta Jodi M Monosso Pushpalatha PN Murthy | 2006 | Protein Expression and Purification2006，46，： | 1 |
| 12 | In vitro and in vivo genotoxicity of silver nanoparticles 显示文摘 | Manosij G M J Sonali S Anirban C | 2012 | Muta- tion Research2012，749，12： | 1 |
| 13 | Physiological and genomic basis of mechanical - functional trade - off in plant vasculature 显示文摘 | Sonali S Amn L M | 2014 | Plant Science2014，5，224： | 1 |
| 14 | Bacterial Flora of Water and Rotifers in Outdoor Mass Culture Tanks Fed with Different Microalagal Diets显示文摘 | Jayasree Lokat Sonali S. M Purbali Saha Philipose K.K. | 2016 | Journal of Life Sciences2016，10，3： | 0 |
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