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| 1 | Hepatoprotective activity of brown alga Padina boergesenii against CCl_4 induced oxidative damage in Wistar rats显示文摘Objective:To investigate the protective effects of brown alga Padina boergesenii(P.boergeseii) against carbon tetrachloride(CCl4) induced oxidative damage and liver fibrosis in rats.Methods: To assess the hepatic damage liver weight,the activities of TBARS level,glutathione,SOD,CAT and GPx in circulation and liver.Results:The group of rats induced with CCl4 alone(2 mL/kg body weight),showed noticeable increase in the liver weight and TBARS level.Followed by, the level of antioxidant enzymes glutathione peroxidase,Superoxide dismutase and catalase was also significantly(P<0.01) diminished.Where as,the rats pretreated with P.boergesenii(150 mg/ kg body weight) modulated the CCl4 induced liver fibrosis.The level of antioxidant enzymes and lipid peroxidation products was found to be significandy(P<0.01) attenuated to near normal level, when compared with rats induced with CCL,alone.In order to assess the role of carotenoids in the relevant activity,total carotenoid content of the extract was analysed and found to be 0.59 mg/g fresh weight(FW).Further,the histopathogical studies provide a supportive evidence for this study to show the protective nature of P.boergesenii.Conclusions:The protective role of brown alga P.boergesenii extract has confirmed its potential activity through its antioxidant sparing actions against CCl4 induced free radical damage.However,the possible mechanism of hepatoprotection is rather speculative at this stage and investigations are underway to isolate and characterize the bioactive compounds from P.boergesenii. | Rajamani Karthikeyan ST Somasundaram T Manivasagam T Balasubramanian P Anantharaman | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 6 |
| 2 | Exergy and energy analysis of three stage auto refrigerating cascade system using zeotropic mixture for sustainable development 显示文摘 | Sivaakumar M Somasundaram P | 2014 | Energy Conversion and Management2014，84，： | 1 |
| 3 | Evolutionary programming based security constrained optimal power flow显示文摘 | Somasundaram P Kuppusamy K Kumudini Devi R P | 2004 | Electric Power Systems Research2004，72，2： | 1 |
| 4 | Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 P13K-PKB/Akt-dependent pathway 显示文摘 | Nair P Somasundaram K Krishna S | 2003 | J Virol2003，77，12： | 1 |
| 5 | Salivagram revisited : justifying its routine use for the evaluation of persistent/ recurrent lower respiratory tract infections in developmentally nor- mal children显示文摘 | Somasundaram VH Subramanyam P Palaniswamy S | 2012 | Ann Nucl Med2012，26，7： | 1 |
| 6 | Application of evolutionary programming to security constrained economic dispatch显示文摘 | Somasundaram P Kuppusamy K | 2005 | International Journal of Electrical Power & Energy Systems2005，27，56： | 1 |
| 7 | Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of Nsaid-enteropathy in the rat显示文摘 | Somasundaram S Sigthorsson G Simpson P d | 2000 | Aliment Pharmcol Ther2000，14，： | 1 |
| 8 | Regulation of smooth muscle myosin heavy chain gene expression in cultured vascular smooth muscle cells by growth factors and contractile angonists 显示文摘 | Somasundaram C Kallmeier RC Babij P | 1995 | Basic Appl Mycol1995，6，1： | 1 |
| 9 | Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma 显示文摘 | SOMASUNDARAM K REDDY S P VINNAKOTA K | 2005 | Oncogene2005，24，： | 1 |
| 10 | Application of evolutionary programming to security constrained economic dispatch显示文摘 | Somasundaram P Kuppusamy K | 2005 | International Journal of Electrical Power & Energy System2005，27，56： | 1 |
| 11 | IgG-induced Ca2+ oscillations in differentiated U937 cells;a study using laser scanning confocal micros copy and coloaded fluo-3 and fura-red fluorescent probes 显示文摘 | FLOTO R A MAHAUT-SMITH M P SOMASUNDARAM B | 1995 | Cell Calcium1995，18，5： | 1 |
| 12 | Protective potential of casein phosphopeptide amorphous calcium phosphate containing paste onenamel surfaces显示文摘 | Somasundaram P Vimala N Mandke LG | 2013 | J Conserv Dent2013，16，2： | 1 |
| 13 | OPF with FACTS De- vices in Interconnected Power Systems Using Fuzzy Stochastic Al- gorithms显示文摘 | PRASANNA T S SOMASUNDARAM P | 2009 | International Journal of Power and Energy Conver- sion2009，1，23： | 1 |
| 14 | Salivagram revisited : justifying its routine use for the evaluation of persistent/ recurrent lower respiratory tract infections in developmentally nor- mal children显示文摘 | Somasundaram VH Subramanyam P Palaniswamy S | 2012 | Ann Nucl Med2012，26，7： | 1 |
| 15 | Economic dispatch with prohibited operating zones using fast computation evolutionary programming algorithm显示文摘 | Somasundaram P Kuppusamy K Devi R P K | 2004 | Electric Power Systems Research2004，70，3： | 1 |
| 16 | Com- parative evaluation of dimensional accuracy of elastomeric Impression materials when treated with autoclave, micro- wave, and chemical disinfection显示文摘 | Kamble SS Khandeparker RV Somasundaram P | 2015 | J Int Oral Health2015，7，9： | 1 |
| 17 | Activated Notchl inhibits p53 -induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K - PKB/Akt - dependent pathway显示文摘 | NAIR P SOMASUNDARAM K KRISHNA S | 2003 | J Virol2003，77，12： | 1 |
| 18 | Solution for Multi- Objective Reactive Power Optimization Using Fuzzy Guided Tabu Search 显示文摘 | STEPHEN D S SOMASUNDARAM P | 2012 | Arabian Journal for Science and Engineering2012，37，8： | 1 |
| 19 | The calciumATPase SERCA2 regulates desmoplakin dynamics andintercellular adhesive strength through modulation ofPKC&-alpha; signaling显示文摘 | Hobbs R P Amargo E V Somasundaram A?Simpson CL Prakriya M Denning M F | 2011 | FASEB J2011，25，： | 1 |
| 20 | Some morphological effects of zinc upon the yolk-sac larvae of Clupea harengus L显示文摘 | Somasundaram B King P E Shackley S E | 1984 | Journal of Fish Biology1984，25，3： | 1 |
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