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| 1 | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells(EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice. | Juan Pías-Peleteiro Francisco Campos José Castillo Tomás Sobrino | 2017 | Neural Regeneration Research2017，12，4： | 4 |
| 2 | Land surface temperature retrieval from LANDSAT TM 5显示文摘 | José A. Sobrino Juan C. Jiménez-Mu?oz Leonardo Paolini | 2004 | Remote Sensing of Environment2004，，4： | 2 |
| 3 | sTWEAK is a marker of early haematoma growth and leukoaraiosis in intracerebral haemorrhage显示文摘Objective To study the association between early growth of haematoma with biomarkers of endothelial dysfunction such as leukoaraiosis(LA)and the soluble tumour necrosis factor-like weak inducer of apoptosis(sTWEAK)in patients with intracerebral haemorrhage(ICH).Methods This is a retrospective observational study of patients with nontraumatic ICH.Clinical and biochemical parameters were analysed.sTWEAK levels were measured by ELISA.LA was analysed in the hemisphere without haemorrhage to avoid interference with the acute injury.The main endpoint was the haematoma growth evaluated by the difference in volume between the second and the initial neuroimage.Poor functional outcome,defined as a modified Rankin Scale>2 at 3 months,was considered as secondary endpoint.Receiver operating characteristic curve analysis was performed to stablish the best cut-off for sTWEAK levels associated with haematoma growth.Results We included 653 patients with ICH in our analysis(71.1±11.9 years,44%women).Haematoma growth was observed in 188 patients(28.8%).sTWEAK levels≥5600 pg/mL predicted ICH growth with a sensitivity of 84%and a specificity of 87%.sTWEAK levels≥5600 pg/mL and the presence of LA were associated with haematoma growth(OR:42.46;(CI 95%22.67 to 79.52)and OR:2.73(CI 95%1.39 to 5.34),respectively).Also,the presence of LA(OR:4.31(CI 95%2.89 to 6.42))and the interaction between ICH growth and sTWEAK(OR:2.23(CI 95%1.40 to 3.55))were associated with poor functional outcome at 3 months.Conclusion sTWEAKs,together with the presence and grade of LA,are biomarkers able to predict ICH growth and poor functional outcome in patients with ICH. | Andrés da Silva-Candal Iria López-Dequidt Manuel Rodriguez-Yañez PauloÁvila-Gómez JoséManuel Pumar JoséCastillo Tomás Sobrino Francisco Campos Ramón Iglesias-Rey Pablo Hervella | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 4 | Land surface temperature retrieval from MSG1-SEVIRI data显示文摘 | J.A. Sobrino M. Romaguera | 2004 | Remote Sensing of Environment2004，，2： | 2 |
| 5 | Acute toxicity of LAS homologues in marine microalgae : esterase activity and inhibition growth as endpoints of toxicity 显示文摘 | HAMPEL M MORENO G I SOBRINO C | 2001 | Ecotoxicol Environ Safety2001，48，： | 1 |
| 6 | Determination of frosts in orange groves from NOAA-9 AVHRR data显示文摘 | Caselles V Sobrino J S | 1989 | Remote Sens Environ1989，29，： | 1 |
| 7 | On the atmospheric dependence of the split-window equation for land surface temperature显示文摘 | Coll C Caselles C Sobrino J A | 1994 | International Journal of Remote Sensing1994，15，1： | 1 |
| 8 | Atmospheric correction for land surface temperature using NOAA-11 AVHRR channels 4 and 5 显示文摘 | Sobrino J A Coil C Caselles V | 1991 | Remote Sensing of Environment1991，38，： | 1 |
| 9 | High serum levels of endothelin- 1 predict severe edema in patients with acute is- chemic stroke treated with t - PA显示文摘 | Modes O Sobrino T Millan M | 2008 | Stroke2008，39，7： | 1 |
| 10 | CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke显示文摘 | Sobrino T Rodriguez-Gonzfilez R Blanco M | 2011 | Neurol Res2011，33，： | 1 |
| 11 | Significance of the remotely sensed thermal infrared measurements obtained over a citrus orchard显示文摘 | Sobrino J A Caselles V Becker F | | 0，，06： | 1 |
| 12 | Usefulness of haptoglobin and scrota amyloid A proteins as biomarkers for atherothrombotic isehemie stroke diagnosis confirmation 显示文摘 | BREAREA D SOBRINO T BLANCO M | 2009 | Atheroselerosis2009，205，2： | 1 |
| 13 | Increased levels of circulating endothelial progenitor cells in patients with ischaemic stroke treated with statins during acute phase显示文摘 | Sobrino T Blanco M Perez-Mato M | 2012 | Eur J Neurol2012，19，： | 1 |
| 14 | Revision of the single-channel algorithm for land surface temperature retrieval from Landsat thermal-infrared data 显示文摘 | Jim6nez-Mufioz J C Crist6bal J Sobrino J A | 2009 | IEEE Transactions on Geoscience and Remote Sensing2009，47，1： | 1 |
| 15 | SNPs in forensic genetics:a review on SNP typing methodologies显示文摘 | Sobrino B Brión M Carracedo A | 2005 | Forensic Sci Int2005，154，： | 1 |
| 16 | Use of nisin and other baeteriocins for preservation of dairy products 显示文摘 | Sobrino Lopez A Martm-Belloso O | 2008 | International Dairy Journal2008，18，： | 1 |
| 17 | Multi-channel and multi-angle algorithms for estimating sea and land surface temperature with ATSR data显示文摘 | Sobrino J A LI Z-L Stoll M P | 1996 | International Journal of Remote Sensing1996，17，： | 1 |
| 18 | Budd-Chiari syndrome with complete occlusion of the inferior vena cava:percutaneous recanalization by angioplasty and stenting显示文摘 | Sanchez-Recalde A Sobrino N Galeote G | 2004 | Cardiovasc Intervent Radiol2004，27，： | 1 |
| 19 | The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome显示文摘 | Sobrino T Hurtado O Moro MA | 2007 | Stroke2007，38，： | 1 |
| 20 | Theoretical split window algorithms for determining the actual surface temperature显示文摘 | Sobrino J A Caselles V Coll C | 1993 | Ⅱ Nuovo Cimento1993，，03： | 1 |
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