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| 1 | 面向复杂产品的分布式协同设计系统显示文摘在回顾国内外并行工程和协同设计发展情况的基础上,结合多学科协同设计优化理论,明确分布式并行协同设计的概念;提出一个基于SORCER(Service oriented computing environment)的面向复杂产品的协同设计系统DCDSCP(Distributed collaborative design system for complex product)。给出DCDSCP的架构和工程软件工具封装和集成为服务的方法,描述服务被调用的临时联盟环境。在DCDSCP支持下,顺序调用Pro/E,HyperMesh,Ansys和Human Expert服务,部署面向机车转向架静态强度分析的协同设计任务,实现在动态网络环境中的可扩展性、可靠性和柔性。计算结果表明:新系统能缩短服务交换周期,支持复杂产品的异地分布式协同设计。 | 于加晴 查建中 陆一平 徐文胜 李楠 M. Sobolewski | 2010 | 中南大学学报(自然科学版)2010，41，2： | 13 |
| 2 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 3 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 4 | The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies显示文摘 | Cyril Sobolewski Claudia Cerella Mario Dicato Lina Ghibelli Marc Diederich Simone Fulda | 2010 | International Journal of Cell Biology2010，，： | 2 |
| 5 | Intravenous thrombolysis patients with acute ischemic stroke:the analysis of the 100cases I:Characteristic of the patients and effectiveness of treatment显示文摘 | Sobolewski P Sledzinska M Szczuchniak W | 2012 | Przeglad Lekarski2012，69，6： | 1 |
| 6 | Evidence for the role of G-proteins in flow stimulation ofdinoflagellate bioluminescence显示文摘 | Chen AK Latz MI Sobolewski P | 2007 | Am J Physiol Regul Integr Comp Physiol2007，，5： | 1 |
| 7 | Disk allocation for Cartesian product files on multiple-disk systems显示文摘 | DU H C SOBOLEWSKI J S | 1982 | ACM Transactions of Database Systems1982，7，1： | 1 |
| 8 | Matrix metallopro-teinases of human leiomyoma in various stages of tumor growth显示文摘 | Olanska M Sobolewski K Bankowski E et a1 | 2004 | Gynecol Obstet Invest2004，58，1： | 1 |
| 9 | Matrix metalloproteinases of human leiomyoma in various stages of tumor growth 显示文摘 | Wolanska M Sobolewski K Bankowski E | 2004 | Gynecol Obstet Invest2004，58，1： | 1 |
| 10 | Network effects and prefer- ence heterogeneity in the case of mobile telecommunications mar- kets 显示文摘 | SOBOLEWSKI M CZAJKOWSKI M | 2012 | Telecommunication Policy2012，36，3： | 1 |
| 11 | The role of cyclooxy-genase-2 in cell proliferation and cell death in human malignancies显示文摘 | SOBOLEWSKI C CERELLA C DICATO M | 2010 | Int J Cell Biol2010，，21： | 1 |
| 12 | Slovak Brown Coals as a Feedstock for the Active Coke Production显示文摘 | Alecksander Sobolewski | 1998 | Acta Montanistica Slovaca1998，，3： | 1 |
| 13 | Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells 显示文摘 | BILLAM M SOBOLEWSKI M D DAVIDSON N E | 2010 | Breast Cancer Res Treat2010，120，3： | 1 |
| 14 | Matrix metalloproteinases in the vein wall显示文摘 | Kowalewski R Sobolewski K Wolanska M | | 0，，2： | 1 |
| 15 | Time-domain characterization of bent coplanar waveguides显示文摘 | ALEXANDROU S SOBOLEWSKI R HSIANG T Y | | 0，，10： | 1 |
| 16 | Wharton' s jelly as a reservoir of peptide growth factors显示文摘 | Sobolewski K MMkowski A Ba fi kowski E | 2005 | Placenta2005，26，10： | 1 |
| 17 | Extra-cellular matrix components in uterine leiomyoma and their alteration during the tumor growth 显示文摘 | Wolanska M Sobolewski K Drozdzewicz | 1998 | Mol Cell Endocrinol1998，189，12： | 1 |
| 18 | Celecoxib prevents curcumin-induced apoptosis in a hematopoietic cancer cell model 显示文摘 | Sobolewski C Muller F Cerella C | 2015 | Mol Carcinog2015，54，10： | 1 |
| 19 | FGF bindingby extracellular matrix components of Wharton 's jelly显示文摘 | Malkowski A Sobolewski K Jaworski S | 2007 | Acta Biochim Pol2007，，2： | 1 |
| 20 | Venous hemodynamic changes during laparoscopic cholecystectomy 显示文摘 | Deshmukh RM Brunson BL | 1995 | J Laparoendosc Surg1995，5，6： | 1 |
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