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| 1 | Acute calculous cholecystitis: Review of current best practices显示文摘Acute calculous cholecystitis(ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery. Laparoscopic cholecystectomy is the best treatment for ACC and the procedure should ideally be performed within 72h. Early surgery is associated with better results in comparison to delayed surgery. In addition, when to suspect associated common bile duct stones and how to treat them when found are still debated. The antimicrobial agents are indicated for high-risk patients and especially in the presence of gallbladder necrosis. The use of broad-spectrum antibiotics and in some cases with antifungal agents is related to better prognosis. Moreover, an emerging strategy of not converting to open, a difficult laparoscopic cholecystectomy and performing a subtotal cholecystectomy is recommended by adept surgical teams. Some authors support the use of percutaneous cholecystostomy as an alternative emergency treatment for acute Cholecystitis for patients with severe comorbidities. | Carlos Augusto Gomes Cleber Soares Junior Salomone Di Saveiro Massimo Sartelli Michel Denis Kelly Camila Couto Gomes Felipe Couto Gomes Lívia Dornellas Correa Camila Brandao Alves Samuel de Fádel Guimaraes | 2017 | World Journal of Gastrointestinal Surgery2017，9，5： | 18 |
| 2 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 3 | Treatability studies of naphthalene in soil,water and air with persulfate activated by iron(Ⅱ)显示文摘Chemical oxidation was applied to an artificially contaminated soil with naphthalene(NAP).Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.Evaluation of NAP distribution and mass reduction in soil,water and air phases was carried out through mass balance.The importance of the air phase analysis was emphasized by demonstrating how NAP behaves in a sealed system over a 4 hr reaction period.Design of Experiments method was applied to the following variables:sodium persulfate concentration[SP],ferrous sulfate concentration[FeS04],and pH.The system operated with a prefixed solid to liquid ratio of 1:2.The following conditions resulted in optimum NAP removal[SP]=18.37 g/L,[FeSO4]=4.25 g/L and pH=3.00.At the end of the 4 hr reaction,62%of NAP was degraded.In the soil phase,the chemical oxidation reduced the NAP concentration thus achieving levels which comply with Brazilian and USA environmental legislations.Besides the NAP partitioning view,the monitoring of each phase allowed the variabilities assessment over the process,refining the knowledge of mass reduction.Based on NAP distribution in the system,this study demonstrates the importance of evaluating the presence of semi-volatile and volatile organic compounds in the air phase during remediation,so that there is greater control of the system as to the distribution and presence of the contaminant in the environment.The results highlight the importance of treating the contaminant in all its phases at the contaminated site. | Gabriela P.Mendes Vivian M.A.Magalhaes Lélia C·R·Soares Rayanne M.Aranha Claudio A.O.Nascimento Marilda M.G.R.Vianna Osvaldo Chiavone-Filho | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 4 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 5 | Fractional Fourier transforms and optical systems显示文摘 | BERNARDO L M SOARES O D D | 1994 | Opt Comm1994，110，： | 1 |
| 6 | Adsorption equilibrium and breakthrough analysis for NO adsorption on activated carbons at low temperatures显示文摘 | Claudino A Soares J L Moreira R F P M | 2004 | Carbon2004，42，： | 1 |
| 7 | Dinamica-a stochastic cellular automata model designed to simulate the landscape dynamics in an Amazonian colonization frontier显示文摘 | Soares B S Cerqueira G C Pennachin C L | 2002 | Ecological Modelling2002，154，3： | 1 |
| 8 | Ratio between positive lymph no- and total dissected axillaries lymph nodes as an independent prognostic factor for disease free survival in patients with breast caneer显示文摘 | Megale Costa L J Soares H P Gaspar H A | 2004 | Am J Clin Oncol2004，27，3： | 1 |
| 9 | Contact indentation of marine composites显示文摘 | Sutherland L S Soares C G | 2005 | Composite Structures2005，70，3： | 1 |
| 10 | Optimal design for active damping in sandwich structures using the Direct MultiSearch method 显示文摘 | Araujo A L Madeira J F A Mota Soares C M | 2013 | Composite Structures2013，105，： | 1 |
| 11 | An array of possibilities for the study of autoimmunity显示文摘 | FATHMAN C G SOARES L CHAN S M | 2005 | Nature2005，435，7042： | 1 |
| 12 | Quantitative detection of poultry meat adulteration with pork by a duplex PCR assay 显示文摘 | Soares S Amaral JS M afra l | 2010 | Meat Sci2010，85，3： | 1 |
| 13 | Prolonged exposure of naive CD8+T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length 显示文摘 | Wallace D L B~rard M Soares M V | 2006 | Immunology2006，119，2： | 1 |
| 14 | Aging effect on the reflectivity measurements of polychloroprene matrices containing carbon black and carbonyl-iron powder显示文摘 | Pinho M S Gregori M L Nunes R C R Soares B G | 2001 | Polymer Degradation and Stability2001，73，： | 1 |
| 15 | Oil spills debris clean up by thermal desorption 显示文摘 | ARARUNA J T PORTES V L O SOARES A P L | 2004 | J Hazard Mater2004，110，123： | 1 |
| 16 | Influence of the alkaline delignification on the simultaneous saccharification and fermentation(SSlr)of sugar cane bagasse显示文摘 | Soares M L Gouveia E R | 2013 | Bioresource Technology2013，147，0： | 1 |
| 17 | Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication 显示文摘 | SOARES J A LEITE F G ANDRADE L G | 2009 | J Virol2009，83，13： | 1 |
| 18 | Development of a finite element model for the identification of mechanical and piezoelectric properties through gradient optimization and experimental vibration data显示文摘 | Araujo A L Mota Soares C M Herskovits J | 2002 | Composite Structures2002，58，： | 1 |
| 19 | Construction and characterization of a normalized cDNA library显示文摘 | Soares M B Bonaldo M F Su L | 1994 | Proc Natl Acad Sci USA1994，91，20： | 1 |
| 20 | Hybrid composites based on polypropylene and carbon fiber and epoxy matrix显示文摘 | Soares B G Campos E A | 2000 | Polym2000，41，10： | 1 |
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