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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Long-term omeprazole treatment in resistant gastroesophageal reflux disease:efficacy,safety,and influence on gastric mucosa显示文摘 | Klinkenberg-Knol EC Nelis F Dent J Snel P Mitchell B Prichard P | 2000 | Gastroenterology2000，118，： | 1 |
| 3 | Genome phylogeny based on gene content显示文摘 | Snel B Bork P Huynen M A | 1999 | Nat Genet1999，21，： | 1 |
| 4 | Acute upper gastrointestinal bleeding in the Amsterdam area: Incidence, diagnosis, and clinical outcome显示文摘 | Vreeburg EM Snel P De Bruijne JW | 1997 | The American Journal of Gastroenterology1997，92，2： | 1 |
| 5 | Greenelectricity production with living plants and bacteria in afuel cell 显示文摘 | Strik D P B T B Hamelers H V M Snel J F H | 2008 | International Journal of Energy Research2008，32，9： | 1 |
| 6 | Genomes in flux:the evolution of archaeal and proteobacterial gene content显示文摘 | Snel B Bork P Huynen M A | 2002 | Genome Res2002，12，1： | 1 |
| 7 | En-hanced mucosal fi brinolytic activity in gastroduo-denal ulcer haemorrhage and the benef icial effect of acid suppression显示文摘 | Vreeburg EM Levi M Rauws EA Deventer SJ Snel P Bartelsman JW Ten Cate JW Tytgat GN | | 0，，07： | 1 |
| 8 | Overview of gut flora and probiotics 显示文摘 | Holzapfel WH Haberer P Snel J | 1998 | Int J Food Microbiol1998，41，2： | 1 |
| 9 | Overiew of gut flora and probiotics 显示文摘 | Holzapfel W H Haberer P Snel J | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 10 | Genome phylogeny based on gene content显示文摘 | Bork P | 1999 | Nat Genet1999，21，1： | 1 |
| 11 | Overview of gut flora and probiotics显示文摘 | Holzapfel W H Haberer P Snel J | 1998 | International Journal of Food Microbiology1998，41，2： | 1 |
| 12 | Genome phylogeny based on gene content显示文摘 | Snel B Bork P | 1999 | Nat Genet1999，21，1： | 1 |
| 13 | Overview of gut flora and probiotics显示文摘 | Holzapfel W H Haberer P Snel J | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 14 | The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract 显示文摘 | Schell M A Karmirantzou M Snel B Vilanova D Berger B Pessi C Zwahlen MC Desiere F Bork P Delley M Pridmore RD Arigoni F | 2002 | Proc Nat Acad Sci USA2002，99，14： | 1 |
| 15 | Overview of gut flora and probiotics 显示文摘 | Holzapfel W H Haberer P Snel J | 1998 | International Journal of Food Microbiology1998，41，： | 1 |
| 16 | Validation of the Rockall risk scoring system in upper gastrointestinal bleeding 显示文摘 | Vreeburg EM Terwee CB Snel P | 1999 | Gut1999，44，3： | 1 |
| 17 | The use of chlorophyll fluorescence and other non-invasive spectroscopic techniques in plant stress physiology显示文摘 | Snel J P H | 1990 | Photosynthesis Research1990，125，： | 1 |
| 18 | 显示文摘 | van der Laag N J Snel M D Magusin P C M M | 2004 | J Euro Ceram Soc2004，24，： | 1 |
| 19 | STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene 显示文摘 | Snel B Lehmann G Bork P | 2000 | Nucleic Acids Res2000，28，18： | 1 |
| 20 | Overview of gut flora and probiotics显示文摘 | HOLZAPFEL W H HABERER P SNEL J | 1998 | International Journal of Food Microbiology1998，41，2： | 1 |
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