|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | Peptide delivery via the pulmonary route: a valid approach for local and systemic delivery 显示文摘 | Smith PL | 1997 | J Controlled Release1997，46，12： | 2 |
| 3 | The IL-2 receptor β chain(p70):role in mediating signals for LAK,NK,and proliferative activities显示文摘 | Siegel JP Sharon M Smith PL | 1987 | Science1987，238，： | 1 |
| 4 | Oral absorption of peptides and proteins显示文摘 | Smith PL Wall DA Gochoco C | 1992 | Adv Drug Deliv Rev1992，8，： | 1 |
| 5 | Herpes simplex virus mediated gene transfer to primate ocular tissues显示文摘 | Liu X Brandt CR Gabelt BT Bryar PJ Smith ME Kaufman PL | 1999 | Exp Eye Res1999，69，4： | 1 |
| 6 | Advanced multiplexed analysis with the FlowMetrix system显示文摘 | Fulton RJ McDade RL Smith PL | 1997 | Clin Chem1997，43，9： | 1 |
| 7 | Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea显示文摘 | Schwartz AR Bennett ML Smith PL | 2001 | Arch Otohryngol Head Neck Surg2001，127，： | 1 |
| 8 | May-Thurner syndrome显示文摘 | LIM WN SMITH PL | 1983 | Radiology1983，147，1： | 1 |
| 9 | Ogilvie syndrome as a postoperative complication 显示文摘 | Tenofsky PL Beamer L Smith RS | 2000 | Arch-Surg2000，135，6： | 1 |
| 10 | Long-term IL-113 exposure causes ganglion neuron excitability subpopulation-dependent al- terations in rat dorsal root ganglion neuron excitability 显示文摘 | STEMKOWSKI PL SMITH PA | 2012 | J Neurophysiol2012，107，6： | 1 |
| 11 | Advanced multiplexed analysis with the FlowMetrix system显示文摘 | Fultion RJ McDade RL Smith PL | 1997 | Chlin Chem1997，43，9： | 1 |
| 12 | Weight loss in mildly to moderately obese patients with obstructive sleep apnea 显示文摘 | Smith PL Gold AR Meyers DA | 1985 | Ann Intern Med1985，103，6： | 1 |
| 13 | Sensory neurons, ion channels, inflammation and the onset of neuropathic pain显示文摘 | Stemkowski PL Smith PA | 2012 | Can J Neurol Sci2012，39，4： | 1 |
| 14 | Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass显示文摘 | Asimakopoulos G Smith PL Ratnatunga CP | 1999 | Ann Thor Surg1999，68，3： | 1 |
| 15 | Upper airway collapsibility in children with obstructive sleep apnea syndrome显示文摘 | Marcus CL McColley SA Carroll JL Loughlin GM Smith PL Schwartz AR | 1994 | J Appl Physiol1994，77，2： | 1 |
| 16 | A rapid, sensitive, multiplexed assay for detection of viral nucleic acids using the FlowMetrix system显示文摘 | Smith PL WalkerPeach CR Fultin RJ | 1998 | Clin Chem1998，44，9： | 1 |
| 17 | Morphologic, immunophenotypic, and molecular evolution of bone marrow innolvement in non - Hodgkins lymphoma 显示文摘 | Crotty PL Smith BR Tallini G | | Pinagn Mol Pathol 19 980，7，2： | 1 |
| 18 | Iron accumulation in Alzheimer disease is a source of redox-generated free radicals显示文摘 | Harris PL Sayre LM | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 19 | A hopelessnessmodel of depressive symptoms in youth with epilepsy显示文摘 | Wagner JL Smith G Ferguson PL | 2009 | J Pediatr Psychol2009，34，1： | 1 |
| 20 | Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass显示文摘 | Asimakopoulos G Smith PL Ratnatunga CP | 1999 | Ann Thorac Surg1999，68，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员