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| 1 | Long-term survival following radiofrequency ablation of colorectal liver metastases: A retrospective study显示文摘AIM: To retrospectively evaluate the long-term survivalof patients that received radiofrequency ablation(RFA) therapies of colorectal liver metastases. METHODS: In 2005 to 2008, RFA of 105 colorectal liver metastases(CRLM) were performed on 49 patients in our institution. The liver metastases were evaluated, both before and after ablation therapies, with contrast enhanced computerised tomography and contrast enhanced ultrasonography. Histological evidence of malignant liver metastases was obtained in the few instances where contrast enhanced ultrasonography gave equivocal results. Accesses to the CRLM were guided ultrasonically in all patients. The data obtained from records of these ablations were retrospectively analysed and survival data were compared with existing studies in the literature.RESULTS: 1-, 2-, 3-, 4- and 5-year survival rates, when no stringent selection criteria were applied, were 92%, 65%, 51%, 41% and 29% respectively. To explore the impact of the number and size of CRLM on patients' survival, an exclusion of 13 patients(26.5%) with number of CRLM ≥ 5 and tumour size ≥ 40 mm resulted in 1-, 2-, 3-, 4- and 5-year survival rates improving to 94%, 69%, 53%, 42% and 31% respectively. It is of note that 9 of 49 patients developed extra-hepatic metastases, not visible or seen on pretreatment scans, just after RFA treatment. These patients had poorer survival. The development of extra-hepatic metastases in nearly 20% of the patients included in our study can partly account for modestly lower survival rates as compared with earlier studies in the literature.CONCLUSION: Our study underscores the fact that optimum patients' selection before embarking on RFA treatment is vitally important to achieving a superior outcome. | Simeon Niyi Babawale Thomas MandФe Jensen Jens BrФndum FrФkjr | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 11 |
| 2 | Effect of Leuconostoc mesenteroides NRRL B- 512F dextransucrase carbon- terminal deletion on dextran and oligosaccharide synthesiset al显示文摘 | Augustin Reverte Magali emaud- simeon R | 1998 | Applied and Environmental Microbiogy1998，5，： | 1 |
| 3 | Phenothiazines inhibit hepatitis C virus entry, likely by in- creasing the fluidity of cholesterol-rich membranes显示文摘 | Chamouu-Emanuelli A M Pecheur E I Simeon R L | 2013 | Antimi- crob Agents Chemother2013，57，6： | 1 |
| 4 | Utility of ITS sequence data for phylogenetic reconstruc- tion of Itatlian Querces spp 显示文摘 | Bellarosa R Simeone M C Papini A | 2005 | Mol Phylogenet Evol2005，34，2： | 1 |
| 5 | Cyclooxygenase-2 uses the protein kinase C/interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells显示文摘 | Simeone AM Nieves-Alicea R MeMurtry VC | 2007 | Int J Oncol2007，30，4： | 1 |
| 6 | Pro grammed cell death 4 inhibits breast cancer cel invasion by in creasing tissue inhibitor of metalloproteinases-2 exprcssion显示文摘 | Nieves Alicea R Colburn NH Simeone AM | | Breast Cancer Res Treat0，114，2： | 1 |
| 7 | ESX/type VII secretion sys-tems and their role in host-pathogen interaction显示文摘 | Simeone R Bottai D Brosch R | 2009 | CurrOpin Microhiol72009，12，1： | 1 |
| 8 | Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction显示文摘 | Qin F Simeone M Patel R | 2007 | Free Radic Biol Med2007，43，2： | 1 |
| 9 | Molecular characterization of a LMW-GS gene located on chromosome 1B and the development of primers specific for the Glu-B3 complex locus in durum wheat显示文摘 | D'Ovidio R Simeone M Masci S | 1997 | Theor Appl Genet1997，95，： | 1 |
| 10 | Genetic map- ping of polyphenol oxidase in tetraploid wheat显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cell Mol Biol- ogy Letters2002，7，： | 1 |
| 11 | Genetic mapping of polyphenol oxidase in tetraploid wheat 显示文摘 | Simeone R Pasqualone A Clodoveo M L | 2002 | Cellular Molecular Biology Letters2002，7，： | 1 |
| 12 | ESX/type Ⅶ secretion systems and their role in host-pathogen interaction 显示文摘 | Simeone R Bottai D Brosch R | 2009 | Curr Opin Microbiol2009，12，1： | 1 |
| 13 | Mat-ing-induced transient inhibition of responses to sex pheromonein a male moth is not mediated by octopaminez or serotonin显示文摘 | BARROZO R B JARRIAULT D SIMEONE X | 2010 | The Journal of Experimental Biology2010，213，： | 1 |
| 14 | Molecular characterization of a LMW-GS gene located on chromosome 1B and the development of primers specific for the Glu-B3 complex locus in durum wheat显示文摘 | D'ovidio R Simeone M Masci S Porceddu E | 1997 | Theoretical and Applied Genetics1997，95，： | 1 |
| 15 | Prospects of bareoding the Italian wild dendroflora: oaks reveal severe limitations to tracking species identity 显示文摘 | Piredda R Simeone M C Attimonelli M | 2010 | Molecular Ecology Resources2010，11，1： | 1 |
| 16 | Programmed Cell Death 4 inhibits breast cancer ceil invasion by increasing tissue inhibitor of metalloproteinases 2 expression显示文摘 | Nieves Alicea R Colburn N H Simeone A M | 2009 | Breast Cancer Res Treat2009，114，2： | 1 |
| 17 | Programmed Cell Death 4 inhibits breast cancer cell asion by increasing Tissue Inhibitor of Metalloproteinases-2 expression显示文摘 | Nieves-Alieea R Simeone AM Taxi A M | 2009 | Breast Cancer Res Treat2009，114，2： | 1 |
| 18 | Descending thoracic aortic dissections显示文摘 | Karmy-Jones R Simeone A Meissner M | 2007 | Surg Clin North Am2007，87，： | 1 |
| 19 | Cyclooxygenase-2 uses the protein kinase C/interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells 显示文摘 | Simeone AM Nieves-Alicca R Mcmurtry VC | 2007 | Int J Oncol2007，30，4： | 1 |
| 20 | Application of plastid and nuclear markers to DNA barcoding of Euro - Mediterranean oaks ( Quercus, Fagaceae) : problems, prospects and phylogenetic impli- cations 显示文摘 | Simeone M C Piredda R Papini A | 2013 | Botanical Journal of the Linnean Society2013，172，4： | 1 |
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