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| 1 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 2 | A new twist in the microRNA pathway: Not Dicer but Argonaute is required for a microRNA production显示文摘 | Gabriel D Bosse Martin J Simard | 2010 | Cell Research2010，20，7： | 7 |
| 3 | Influence of cardiac nerve status on cardiovascular regulation and cardioprotection显示文摘Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk is critical for normal function of the heart and other organs; derangements within the nervous system hierarchy contribute to pathogenesis of organ dysfunction. The role of intact cardiac nerves in development of, as well as protection against, ischemic injury is of current interest since it may involve recruitment of intrinsic cardiac ganglia. For instance, ischemic conditioning, a novel protection strategy against organ injury, and in particular remote conditioning, is likely mediated by activation of neural pathways or by endogenous cytoprotective bloodborne substances that stimulate different signalling pathways. This discovery reinforces the concept that inter-organ communication, and maintenance thereof, is key. As such, greater understanding of mechanisms and elucidation of treatment strategies is imperative to improve clinical outcomes particularly in patients with comorbidities. For instance, autonomic imbalance between sympathetic and parasympathetic nervous system regulation can initiate cardiovascular autonomic neuropathy that compromises cardiac stability and function. Neuromodulation therapies that directly target the intrinsic cardiac nervous system or other elements of the nervous system hierarchy are currently being investigated for treatment of different maladies in animal and human studies. | John G Kingma Denys Simard Jacques R Rouleau | 2017 | World Journal of Cardiology2017，9，6： | 6 |
| 4 | Hepatitis B Virus Infection: Epidemiology and Vaccination显示文摘 | Colin W. Shepard Edgar P. Simard Lyn Finelli Anthony E. Fiore Beth P. Bell | 2006 | Epidemiologic Reviews2006，，： | 6 |
| 5 | Synthesis of Single-Walled Carbon Nanotubes by Induction Thermal Plasma显示文摘The production of high quality single-walled carbon nanotubes(SWCNTs)on a bulk scale has been an issue of considerable interest.Recently,it has been demonstrated that high quality SWCNTs can be continuously synthesized on large scale by using induction thermal plasma technology.In this process,the high energy density of the thermal plasma is employed to generate dense vapor-phase precursors for the synthesis of SWCNTs.With the current reactor system,a carbon soot product which contains approximately 40 wt%of SWCNTs can be continuously synthesized at the high production rate of~100 g/h.In this article,our recent research efforts to achieve major advances in this technology are presented.Firstly,the processing parameters involved are examined systematically in order to evaluate their individual inuences on the SWCNT synthesis.Based on these results,the appropriate operating conditions of the induction thermal plasma process for an effective synthesis of SWCNTs are discussed.A characterization study has also been performed on the SWCNTs produced under the optimum processing conditions.Finally,a mathematical model of the process currently under development is described.The model will help us to better understand the synthesis of SWCNTs in the induction plasma process. | Keun Su Kim Ala Moradian Javad Mostaghimi Yasaman Alinejad Ali Shahverdi Benoit Simard Gervais Soucy | 2009 | Nano Research2009，2，10： | 4 |
| 6 | 在缺血性卒中后新表达的由SUR1调控的NCCa-ATP通道介导脑水肿显示文摘中枢神经系统的病理状况(如卒中和脑外伤)通常因脑水肿而有所加剧。研究人员最近在缺血的星形胶质细胞发现了一种非选择性的阳离子通道,即NCCa—ATP通道。这种通道由磺酰脲受体1(SUR1)调控,在ATP耗竭时开放,并且这种开放会造成细胞毒性水肿。在本文中,作者通过建立啮齿类动物中风模型来评估这种通道机制的参与过程。 | J Marc Simard Mingkui Chen Kirill V Tarasov | 2006 | 国际内科双语杂志(中英文)2006，6，6： | 4 |
| 7 | Supporting and strengthening research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of poverty:scoping reviews and research gap analysis显示文摘Background:More than half of the world’s population currently lives in urban settlements that grow both in size and number.By 2050,approximately 70%of the global population will be living in urban conglomerations,mainly in low-and middle-income countries.Mobility,poverty,different layers of inequalities as well as climate variability and change are some of the social and environmental factors that influence the exposure of human populations in urban settings to vector-borne diseases,which pose eminent public health threats.Accurate,consistent,and evidencebased interventions for prevention and control of vector-borne and other infectious diseases of poverty in urban settings are needed to implement innovative and cost-effective public policy and to promote inclusive and equitable urban health services.Main body:While there is growing awareness of vector-borne diseases epidemiology at the urban level,there is still a paucity of research and action being undertaken in this area,hindering evidence-based public health policy decisions and practice and strategies for active community engagement.This paper describes the collaboration and partnership of the Special Programme for Research and Training in Tropical Diseases(TDR)hosted by the World Health Organization(WHO)and the“VEctor boRne DiseAses Scoping reviews”(VERDAS)Research Consortium as they joined efforts in response to filling this gap in knowledge and evidence by supporting the development of a series of scoping reviews that highlight priority research gaps and policy implications to address vector-borne and other infectious diseases at the urban level.Conclusions:The set of scoping reviews proposed in this special issue presents a critical analysis of the state-of-the-art of research on urban health interventions for the prevention and control of vector-borne and other infectious diseases of poverty.The authors of the 6 reviews highlighted severe gaps in knowledge and identified organizational and theoretical limitations that need to be urgently tackled to improve cities preparedness and vector control response.The more pressing need at present is to ensure that more implementation research on vector-borne diseases in urban settings is conducted,addressing policy and practice implications and calling for more political commitment and social mobilization through adequate citizen engagement strategies. | Mariam Otmani del Barrio Frederic Simard Andrea Caprara | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 8 | Biological profiles in subjects with recurrent acute coronary events compared with subjects with long-standing stable angina 显示文摘 | BOGATY P POIRIER P SIMARD S | 2001 | Circulation2001，103，25： | 2 |
| 9 | Enhancement of mechanical performance of epoxy/carbon fiber laminate composites using single-walled carbon nanotubes显示文摘 | Behnam Ashrafi Jingwen Guan Vahid Mirjalili Yunfa Zhang Li Chun Pascal Hubert Benoit Simard Christopher T. Kingston Orson Bourne Andrew Johnston | 2011 | Composites Science and Technology2011，，13： | 2 |
| 10 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 11 | 法国梨主栽品种和砧木利用现状显示文摘法国选育出许多优良梨品种、梨砧木品种,并在世界广泛应用,对世界梨产业的发展具有重要贡献。简要介绍了法国梨主栽品种的生产情况、品种特点以及梨砧木利用情况、砧木特点等,并对我国梨品种和梨砧木的选育迚行了展望。 | 王斐 姜淑苓 Fran?ois Laurens Marie-Hélène Simard 欧春青 张艳杰 方明 马力 赵亚楠 | 2019 | 中国果树2019，，6： | 2 |
| 12 | PNAS:科学家首次鉴别出让寨卡病毒如此致命的关键蛋白显示文摘当寨卡病毒横空出世时科学家们对其知之甚少。在过去一年里研究者们通过深入研究来阐明寨卡病毒为何会引发一系列危险的健康问题。包括新生儿缺陷等,比如小头畸型和神经性问题(格--巴二氏综合征等)。但研究者们并不知道寨卡病毒哪种蛋白会让其变得具有杀伤性。当然他们也不清楚这些蛋白质的作用机理是什么。 | Ge Li Melissa Poulsen Csaba Fenyvuesvolgyi Yoko Yashiroda Minoru Yoshida J. Marc Simard Robert C. Gallo Richard Y. Zhao | 2017 | 现代生物医学进展2017，17，3： | 2 |
| 13 | Achieving accuracy requirements for forest biomass mapping: A spaceborne data fusion method for estimating forest biomass and LiDAR sampling error显示文摘 | P.M. Montesano B.D. Cook G. Sun M. Simard R.F. Nelson K.J. Ranson Z. Zhang S. Luthcke | 2013 | Remote Sensing of Environment2013，，： | 2 |
| 14 | Increased aquaporin-4 expression in ammonia-treated cultured astrocytes显示文摘 | Rama-Rao KV Chen M Simard JM | 2003 | Neuroreport2003，14，18： | 1 |
| 15 | Inhibition of surface spoilage bacteria in processed meats by application of antimicrobial films prepared with chitosan显示文摘 | B Ouattara R E Simard G Piette | 2000 | Microbiology2000，62，： | 1 |
| 16 | Protective immune responses induced by the immunization of mice with a recombinant phage displaying an epitope of the human respiratory syncytial virus显示文摘 | BASTIEN N TRUDEL M SIMARD C | 1997 | Virology1997，234，1： | 1 |
| 17 | Phosphorus loss in agricultural drainage: Historical perspective and current research显示文摘 | Sims J T Simard R R Joern B C | 1998 | Journal of Environmental Quality1998，27，： | 1 |
| 18 | Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cells显示文摘 | Simard J De Launoit Y Haagensen DE | 1992 | Endocrinology1992，130，3： | 1 |
| 19 | Molecular mechanisms of ischemiccerebral edema: role of electroneutral ion transport显示文摘 | Kahle KT Simard JM Staley KJ | 2009 | Physiology (Bethesda)2009，，24： | 1 |
| 20 | Psychological distress among adolescents living with a parent with advanced cancer显示文摘 | Rainville F Dumont S Simard S | 2012 | Psychosoc Oncol2012，30，5： | 1 |
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