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| 1 | 将卒中纳入心血管风险预测工具美国心脏协会/美国卒中协会对医疗卫生专业人员的声明显示文摘背景和目的目前美国针对心血管事件风险预测以及一级和二级预防的指南声明均使用绝对风险估计值来识别血管事件高危患者以及可从特定干预措施中获益的患者。然而,这些指南并未明确地包括卒中患者。本指南对现有证据和争论进行概述以支持:(1)将卒中(尤其是动脉粥样硬化性卒中)患者纳入心血管病绝对风险增高的患者群体;(2)将卒中纳入血管性疾病风险预测工具的转归预测因素。方法和结果写作组成员由委员会联合主席基于先前在相关领域的研究成果来提名,并得到美国心脏协会(American Heart Association,AHA)卒中委员会科学声明监督委员会以及文稿监督委员会的批准。作者采用系统文献回顾(覆盖1980年1月至2010年3月期间的文献)并参考以往公布的指南、个人资料以及专家观点,以归纳现有证据,提出当前知识的不足,并根据AHA标准对适当的问题制定推荐意见。所有写作组成员均有机会对推荐意见进行评论并批准了最终版本。经广泛的AHA内部同行评议以及卒中委员会领导阶层和科学声明监督委员会的审阅后,最终获得AHA科学咨询和协调委员会的批准。将卒中患者(尤其是动脉粥样硬化性卒中患者)纳入冠状动脉和心血管病绝对高危人群的原因如下。首先,有证据显示,缺血性卒中患者发生致死性和非致死性心肌梗死或猝死的绝对风险增高,10年绝对风险≥20%,这一风险阈值已被一些指南用于定义冠状动脉疾病风险等危症。其次,纳入动脉粥样硬化性卒中的原因与纳入糖尿病、周围血管病、慢性肾脏病以及其他动脉粥样硬化性疾病的原因相同,尽管尚缺乏在所有人群或患者中风险增高的统一证据。再次,缺血性卒中的大动脉粥样硬化性卒中亚型与其他这些疾病的病理生理学机制相同。将卒中纳入高危因素将导致高危人群的数量扩大约10%。然而,由于卒中的异质性,尚不确定其他卒中亚型,包括出血性卒中以及非动脉粥样硬化性卒中亚型,是否应被视为具有相同水平的风险,因此有待进一步研究。鉴于卒中对残疾和死亡的影响、卒中与其他血管性疾病预防措施的相似性以及卒中在某些人群中较冠状动脉疾病更高的重要性,将卒中、心肌梗死和猝死纳入心血管事件风险预测工具的转归预测因素是合适的。美国以外的指南常常将卒中患者纳入心血管高危人群,并将卒中作为心脏终点的一个相关转归事件。结论动脉粥样硬化性卒中患者应被纳入会进一步发生冠状动脉粥样硬化事件的高危患者(10年≥20%)。是否应纳入非动脉粥样硬化卒中亚型尚不确定。对于一级预防,缺血性卒中应被纳入绝对风险评估方案的心血管疾病转归事件。将动脉粥样硬化性卒中作为一个高危因素或者更宽泛地将缺血性卒中视作一种转归事件纳入,可能对心血管病的预防具有重要意义,因为被评定为高危风险的患者数量将大幅增加。 | Daniel T. Lackland Mitchell S.V. Elkind Ralph D'Agostino Sr Mandip S. Dhamoon David C. Goff Jr Randall T. Higashida Leslie A. McClure Pamela H. Mitchell Ralph L. Sacco Cathy A. Sila Sidney C. Smith Jr David Tanne David L. Tirschwell Emmanuel Touze Lawrence R. Wechsler 4:~ 尤寿江(译) 于海龙(译) 刘慧慧(译) 张霞(译) 刘春风(译) | 2012 | 国际脑血管病杂志2012,20,11: | 13 |
| 2 | Recent advances in sturgeon nutrition显示文摘Sturgeons are fish species of biological and economical importance, and most of them are endangered,vulnerable or rare because of their large size, late sexual maturity, long period between spawning, and longevity. These unique biological characteristics make them highly susceptible to overfishing, degradation of habitat and spawning ground, and contamination of water and sediments by pollutants. The objective of the current review is not to exhaustively include all studies on sturgeon nutrient requirements and utilizations conducted under laboratory conditions, but to critique some studies and update previous reviews. The goal is to provide a basis for recommendations for future research so that these important fish species can be managed and produced sustainably. Energy, protein, lipid carbohydrate, vitamin, and mineral requirements and utilizations were reviewed or critiqued. Future studies to develop suitable chemically defined diets to support good growth of sturgeon are urgently needed.Furthermore, future experiments should be designed systematically with more consideration on within and among studies and within and among different species of sturgeon. Finally, future experiments should be designed with a systematic approach with multiple doses(inputs) and multiple responses(outputs) at several levels of hierarchical organization in a biological system using traditional biochemical and modern molecular techniques and computer modeling with proper experimental design and methodology. This approach will provide a more realistic and holistic understanding of the mechanisms of nutrient requirements and utilizations, which will help us better manage wild sturgeon stocks and produce sturgeon more efficiently and sustainably under aquaculture conditions. | Silas S.O.Hung | 2017 | Animal Nutrition2017,,3: | 12 |
| 3 | CEUS and Fibroscan in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis显示文摘AIM: To determine intra-hepatic blood flow and liver stiffness in patients with non-alcoholic fatty liver disease(NAFLD) and non-alcoholic steatohepatitis (NASH) using contrast-enhanced ultrasound and fibroscan.METHODS: This prospective study included 15 patients with NAFLD, 17 patients with NASH and 16 healthy controls.In each patient, real-time ultrasound was used to locate the portal vein (PV) and the right liver lobe, and 5 mL of SonoVue? was then injected intravenous in a peripheral vein of the left arm over a 4-s span. Digital recording was performed for 3 min thereafter. The recording was subsequently retrieved to identify an area of interest in the PV area and in the right liver parenchyma(LP) to assess the blood flow by processing the data using dedicated software (Qontrast?, Bracco, Italy).The following parameters were evaluated: percentage of maximal contrast activity (Peak%), time to peak (TTP, s), regional blood volume (RBV, cm3), regional blood flow (RBF, cm3/s) and mean transit time (MTT, s).At 24-48 h post-injection, liver stiffness was evaluated using Fibroscan and measured in kPa. The statistical evaluation was performed using Student’s t test.RESULTS: In the PV, the Peak%, RBV and RBF were significantly reduced in the NAFLD and NASH patientscompared with the controls (Peak%: NAFLD 26.3 ± 6.6,NASH 28.1 ± 7.3 vs controls 55.8 ± 9.9, P < 0.001;RBV: NAFLD 4202.3 ± 3519.7, NASH 3929.8 ± 1941.3vs controls 7473 ± 3281, P < 0.01; RBF: NAFLD 32.5± 10.8, NASH 32.7 ± 12.1 vs controls 73.1 ± 13.9, P< 0.001). The TTP in the PV was longer in both patient groups but reached statistical significance only in the NASH patients compared with the controls (NASH 79.5± 37.8 vs controls 43.2 ± 30, P < 0.01). In the LP,the Peak%, RBV and RBF were significantly reduced in the NAFLD and NASH patients compared with the controls (Peak%: NAFLD 43.2 ± 7.3, NASH 41.7 ± 7.7 vs controls 56.6 ± 6.3, P < 0.001; RBV: NAFLD 4851.5± 2009, NASH 5069.4 ± 2292.5 vs controls 6922.9 ±2461.5, P < 0.05; RBF: NAFLD 55.7 ± 10.1, NASH 54.5 ± 12.1 vs controls 75.9 ± 10.5, P < 0.001). The TTP was longer in both patient groups but did not reach statistical significance. The MTT in both the PV and LP in the NAFLD and NASH patients was not different from that in the controls. Liver stiffness was significantly increased relative to the controls only in the NASH patients(NASH: 6.4 ± 2.2 vs controls 4.6 ± 1.5, P < 0.05).CONCLUSION: Blood flow derangement within the liver present not only in NASH but also in NAFLD suggests that a vascular flow alteration precedes liver fibrosis development. | Sila Cocciolillo Giustino Parruti Leonardo Marzio | 2014 | World Journal of Hepatology2014,6,7: | 7 |
| 4 | Physical Model Testing of Compaction Grouting in Cohesionless Soil显示文摘 | Silas C. Nichols Deborah J. Goodings | 2000 | Journal of Geotechnical and Geoenvironmental Engineering2000,,9: | 3 |
| 5 | 长江流域不同地质生态环境土壤碳酸酐酶活性、有机碳含量及其相关性显示文摘为了探讨流域岩溶生态系统土壤碳酸酐酶(CA)活性、有机碳含量及CA固碳之间的潜在关系,选取长江流域干流及支流沿岸不同地质生态环境下的10个样地,比较长江流域不同地质生态环境下表层土壤(0--20cm)中的碳酸酐酶(CA)活性与土壤有机碳(SOC)含量,并分析二者之间的关系。结果表明:(1)长江流域岩溶区的表层土壤CA活性要高于非岩溶区(P〈0.01),土壤CA活性的差异与样地的地质类型及植被类型不同有关;(2)位于岩溶区高场(GC)样地的年平均SOC含量最高(1.09%),而位于非岩溶区外洲(WZ)样地的年平均SOC含量最低(0.29%),而且总体比较而言,长江流域冬季表层土壤的平均SOC含量显著高于夏季(P〈0.01);(3)相关性分析结果显示,不同季节长江流域岩溶区表层土壤CA活性与SOC含量呈一定的正相关。研究结果为进一步研究流域岩溶生态系统土壤CA与土壤固碳能力之间的关系奠定了基础。 | 潘伟志 Sila Onesmus Nzung’a 申泰铭 李为 王晨玮 余龙江 | 2016 | 中国岩溶2016,35,2: | 3 |
| 6 | Comparative study of carbonic anhydrase activity in waters among different geological eco-environments of Yangtze River basin and its ecological significance显示文摘This study provides the presence of carbonic anhydrase(CA) activity in waters of the Yangtze River basin, China, as well as the correlation of CA activity with HCO-3 concentration and CO_2 sink flux. Different degrees of CA activity could be detected in almost all of the water samples from different geological eco-environments in all four seasons. The CA activity of water samples from karst areas was significantly higher than from non-karst areas(PP3-concentration(r = 0.672, P2 sink flux(r = 0.602, P = 0.076) in karst areas. This suggests that CA in waters might have a promoting effect on carbon sinks for atmospheric CO_2 in karst river basins. In conditions of similar geological type, higher CA activity was generally detected in water samples taken from areas that exhibited better eco-environments, implying that the CA activity index of waters could be used as an indicator for monitoring ecological environments and protection of river basins. These findings suggest that the role of CA in waters in the karst carbon sink potential of river basins is worthy of further in-depth studies. | Sila Onesmus Nzung'a Weizhi Pan Taiming Shen Wei Li Xiaoqun Qin Chenwei Wang Liankai Zhang Longjiang Yu | 2018 | Journal of Environmental Sciences2018,30,4: | 3 |
| 7 | Analysis of factors associated with durable remission of diabetes after Roux-en- Y gastric bypass显示文摘 | Silas M. Chikunguwo Luke G. Wolfe Patricia Dodson Jill G. Meador Nancy Baugh John N. Clore John M. Kellum James W. Maher | 2010 | Surgery for Obesity and Related Diseases2010,,3: | 2 |
| 8 | Nanosized GdVO_4 powders synthesized by sol-gel method using different carboxylic acids显示文摘Nanosized GdVO_4 powders were synthesized via a sol-gel method using different carboxylic acids as chelating agent, followed by calcination at 600 ℃ for 3 h.The effect of different carboxylic acids such as citric acid,malic acid, and tartaric acid on the characteristics of the nanosized GdVO_4 powders was investigated. The GdVO_4 powder was also synthesized without carboxylic acid for comparison. The thermal decomposition process of the carboxylate precursors was investigated by thermogravimetric differential thermal analysis(TG-DTA). X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscope(FESEM),transmission electron microscope(TEM), and surface area measurement data were used to confirm the formation of nanocrystalline GdV04 powders. It is found that the synthesis using the carboxylic acid with higher heat of combustion results in the powder with larger crystallite size. The difference in the steric effect of the acids used,which was evaluated by a computational method, also affects the degree of agglomeration of the synthesized powders. | Sulawan Kaowphong Nawapong Chumha Piyarat Nimmanpipug Sila Kittiwachana | 2018 | Rare Metals2018,37,7: | 2 |
| 9 | Transfusion-related acute lung injury in ICU patients admitted with gastrointestinal bleeding显示文摘 | Alexander B. Benson Gregory L. Austin Mary Berg Kim K. McFann Sila Thomas Gina Ramirez Hugo Rosen Christopher C. Silliman Marc Moss | 2010 | Intensive Care Medicine2010,,10: | 2 |
| 10 | Pectins in processed fruits and vegetables: Part III--stability and catalytic activity of pectinases显示文摘 | Duvetter T Sila D N Van Buggenhout S | 2009 | Comprehensive Reviews in Food Science and Food Safety2009,8,2: | 1 |
| 11 | CFD analysis of station fire conditions in Buenos Aires subway显示文摘 | Li Silas K L Kennedy W D | 1999 | ASHRAE Transactions1999,105,1: | 1 |
| 12 | Examining the effects of contextual factors on TQM and performance through the lens of organizational theo- ries :An empirical study显示文摘 | Sila I | 2007 | Journal of Operations Manage- ment2007,25,1: | 1 |
| 13 | Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage显示文摘 | Gebel JM Brott TG Sila CA | 2000 | Stroke2000,31,3: | 1 |
| 14 | Decreased perihematomal edema in thrombolysis-related intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage显示文摘 | Brott TG Sila CA | 2000 | Stroke2000,31,: | 1 |
| 15 | Decreased perihematomal edema in thrombolysis-reduced intracerebral hemorrhage compared with spontaneous intracerebral hemorrhage显示文摘 | Gebel J M Brott T G Sila C A | 2000 | Stroke2000,31,3: | 1 |
| 16 | Complications of photorefractive keratectomy and laser in situ keratomileusis 显示文摘 | LUI M M SILAS M A FUGISHIMA H | 2003 | J Refract Surg2003,19,2: | 1 |
| 17 | Pectin fraction interconversions: insight into understanding texture evolution of thermally processed carrots显示文摘 | SILA D N DOUNGLA E SMOUT C VAN LOEY A | 2006 | Journal of Agricultural and Food Chemistry2006,54,22: | 1 |
| 18 | Effect of high pressure/high temperature processing on cell wall pecticsubstances in relation to firmness of carrot tissue 显示文摘 | Roeck A D Sila D N Duvetter T | 2008 | Food Chemistry2008,107,3: | 1 |
| 19 | Examining the effects of contextual factors on TQM and per- formance through the lens of organizational theories: An empirical study 显示文摘 | SILA I | 2007 | Journal of Operations Management2007,25,1: | 1 |
| 20 | Construction cost factors in Nigeria显示文摘 | A Uchechukwu Ellnwa Silas A Buba | 1993 | Journal of Construction Engineering and Management1993,119,4: | 1 |