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| 1 | Manufacturing tolerant topology optimization显示文摘In this paper we present an extension of thetopology optimization method to include uncertainties dur-ing the fabrication of macro,micro and nano structures.Morespecifically,we consider devices that are manufactured usingprocesses which may result in(uniformly)too thin(eroded)or too thick(dilated)structures compared to the intendedtopology.Examples are MEMS devices manufactured usingetching processes,nano-devices manufactured using e-beamlithography or laser micro-machining and macro structuresmanufactured using milling processes.In the suggestedrobust topology optimization approach,under- andover-etching is modelled by image processing-based 'erode'and 'dilate' operators and the optimization problem is for-mulated as a worst case design problem.Applications ofthe method to the design of macro structures for minimumcompliance and micro compliant mechanisms show that themethod provides manufacturing tolerant designs with littledecrease in performance.As a positive side effect the robustdesign formulation also eliminates the longstanding prob-lem of one-node connected hinges in compliant mechanismdesign using topology optimization. | Ole Sigmund | 2009 | Acta Mechanica Sinica2009，25，2： | 12 |
| 2 | Exploiting Additive Manufacturing Infill in Topology Optimization for Improved Buckling Load显示文摘增材制造可实现优质多功能构件所具有的高度复杂几何构型的制备。可以直接制备内含多孔填充的结构部件是其独有特征的一个例证。现有的设计方法还难以充分利用这一设计自由度,直接获得类似结构的设计。本文将展示涂层方法 (coating approach)的拓扑优化方法来作为多孔填充构件的设计方法,所设计的构件具有显著改进的临界屈曲载荷,从而使得整体结构部件的稳定性增强。传统的柔顺性拓扑优化方法极少在数学模型中考虑构件的屈曲约束,稳定性要求通常要经过后续的校核与改进过程满足。这一后续过程往往只能获得次优设计。本文所展示的方法弥补了传统柔顺性拓扑优化模型中难以考虑构件屈曲约束的缺陷。利用涂层拓扑优化方法与传统柔顺性拓扑优化同时对经典的MBB梁进行设计,并采用熔丝增材制造技术对设计结果进行了制备。实验结果验证了涂层方法的数学模型的正确性。由于填充材料的性质,在相同条件下,涂层优化得到的多孔填充结构的屈曲载荷比传统优化得到的实体结构高四倍以上。 | Anders Clausen Niels Aage Ole Sigmund | 2016 | Engineering2016，2，2： | 9 |
| 3 | T1影像高信号肾脏病变:DWI与MR增强检查鉴别诊断的比较显示文摘目的比较测量MR扩散加权成像(DWI)的表观扩散系数(ADC)与MR增强检查对鉴别不含脂肪T1高信号肾脏病变的能力。以组织病理学分析和随访影像作为参照标准。方法机构伦理审查委员会批准了符合HIPAA法案的回顾性研究计划,免除知情同意。2位观察者独立回顾性分析41例在MR T1影像上呈高信号的肾脏病变。MRI检查包括DWI和T1对比增强成像。对每一人组病变,观察者评价(a)ADC均值(±标准差)、(b)增强率和(C)为确定增强的存在而做的减影影像(可信性评分,1~5分)。 | S. Kim M. Jain A.B. Harris V.S. Lee J.S. Babb E.E. Sigmund 徐勐(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 9 |
| 4 | Theory of sputtering I-Sputtering yield of amorphous and polycrystalline 显示文摘 | Sigmund P | 1969 | Physics Review1969，184，2： | 2 |
| 5 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 6 | Material interpolation schemes in topology optimization显示文摘 | M. P. Bends?e O. Sigmund | 1999 | Archive of Applied Mechanics (-)1999，，9： | 2 |
| 7 | 更快、更高、更强?运动行为道德和不道德的解释(英文)显示文摘 | Sigmund Loland | 2008 | 体育科学2008，28，9： | 2 |
| 8 | A 99 line topology optimization code written in Matlab显示文摘 | O. Sigmund | 2001 | Structural and Multidisciplinary Optimization2001，，2： | 2 |
| 9 | Synthesis of YAG by a citrate-nitrate combustion technique显示文摘 | Roy Sukumar Wang Liwu Sigmund Wolfgang | 1999 | Mater lett1999，39，： | 2 |
| 10 | Design of materials with extreme thermal expansion using a three--phase topology optimization method 显示文摘 | Sigmund S Torquato | 1997 | J Mech Phys Solids1997，45，6： | 1 |
| 11 | Material interpolation schemes in topology optimization显示文摘 | BENDSФE M P SIGMUND O | 1999 | Archive Appl Mech1999，69，910： | 1 |
| 12 | Numerical instabilities in topology optimization:A survey on procedure dealing with checkerboards, mesh-dependencies and local minima 显示文摘 | Sigmund O | 1998 | Structural Optimization1998，16，1： | 1 |
| 13 | On the design of compliant mechanisms using topology optimization显示文摘 | Sigmund O | 1997 | Mechanics of Structures and Machines1997，25，4： | 1 |
| 14 | Topological dynamics of transformations induced on the space of probability measures显示文摘 | Bauer W Sigmund K | 1975 | Monatsh Math1975，79，： | 1 |
| 15 | Slope constrained topology optimization 显示文摘 | Petersson J Sigmund O | 1998 | International Journal for Numerical Methods in Engineering1998，41，8： | 1 |
| 16 | Zinc oxide nanowires on carbon nano- tubes 显示文摘 | Kim H Sigmund W | 2002 | Appl Phys Lett2002，81，11： | 1 |
| 17 | Slope constrained topology optimization显示文摘 | Petersson J Sigmund O | 1998 | International Journal for Numerical Methods in Engineering1998，41，： | 1 |
| 18 | The management of nonpigmented gallstones in children显示文摘 | Steven WB Sigmund HE Catharine R | | 0，，05： | 1 |
| 19 | Numerical Instabilities in Topology Optimization:A Survey on Procedures Dealing with Checkerboards,Mesh-dependencies and Local Minima显示文摘 | Sigmund O Petersson J | | 0，，： | 1 |
| 20 | Impact of vocal effort variability on automatic speech recognition 显示文摘 | ZELINKA P SIGMUND M SCHIMMEL J | 2012 | Speech Communica- tion2012，54，6： | 1 |
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