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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | Acid-base characteristics of aspbahenes isolated from mechanical sheared oil distillation residues 显示文摘 | Siffert B Rageul P Papirer E | 1996 | Fuel1996，75，14： | 1 |
| 4 | Gas displacement of viscoplastic liquids in capillary tubes 显示文摘 | De Souza MENDES P R DUTRA E S S SIFFERT J R R | 2007 | Journal of Non-Newtonian Fluid Mechanics2007，145，1： | 1 |
| 5 | Worldwide ethnic distribution of the G-protein beta 3 subunit 825T allele and its association with obesity in Caucasian,Chinese and Black African individual显示文摘 | Siffert W Forster P Jochel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 6 | Worldwide ethnic distribution of the G protein 133 subunit 825T allele and its association with obesity in Caucasian,Chinese,and Black African individuals 显示文摘 | Siffert W Forster P Jockel K-H | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 7 | Worldwide Ethnic Distribution of the G-Protein β3 Subunit C825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals显示文摘 | Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 8 | Worldwide ethnic distribution of the G protein beta 3 subunit 825T allele and its association with obesity in Caucasian,Chinese,and Black African individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 9 | Properties of Vapour Phase Grown Mercuric Iodide Single Crystal Detectors显示文摘 | Ponpon J P Stuck R Siffert P | 1975 | IEEE Transaction Nuclear Science1975，22，1： | 1 |
| 10 | Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese,and Black African individuals 显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 11 | Calculated temperature distribution during laser annealing in silicon and cadmium telluride 显示文摘 | BELL R O TOULEMONDE M SIFFERT P | 1979 | Appl Phys1979，19，3： | 1 |
| 12 | Wordwide ethnicdistribution of the G protein beta3subunit 825Tallele and itsassociation with obesity in Caucasian,Chinese and BlackAfrican individuals显示文摘 | Siffert W Rorester P Jockel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 13 | Worldwide ethnic distribu-tion of the g - protein (33 subunit c825T allele and its associationwith obesity in Caucasian, Chinese, and black Afican individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，： | 1 |
| 14 | Worldwide ethnic distribution of the G protein B3 subunit 825T allele and its association with obesity in aucasian Chinese,and Black African individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | Am Soc Nephrol1999，10，： | 1 |
| 15 | Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian,Chinese,and Black African individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 16 | Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，9： | 1 |
| 17 | Thrombin-induced cytosolic alkalinization in human platelets occurs without an apparent involvement of HCO3-/Cl- exchange显示文摘 | Clemens N Siffert W Scheid P | 1990 | Pflugers Arch1990，416，12： | 1 |
| 18 | Parameters affecting the sign andmagnitude of the eletrokinetic potential of calcite 显示文摘 | Siffert B Fimbel P | 1984 | Colloids andSurfaces1984，11，： | 1 |
| 19 | Acid-base characteristics of asphaltenes isolated from mechanical sheared oil distillation residues显示文摘 | SIFFERT B RAGEUL P PAPIRER E | 1996 | Fuel1996，75，14： | 1 |
| 20 | Worldwide ethnic distribution of the G - Protein p3 subunit C 825T allele and its association with besity in Caucasian, Chinese, and Black Afican Individuals显示文摘 | Siffert W Forster P Jockel KH | 1999 | J Am Soc Nephrol1999，10，： | 1 |
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