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| 1 | 阿司匹林在冠心病二级预防中的应用现况显示文摘目的了解中国多省市冠心病患者阿司匹林应用现况。方法以2781例既往曾确诊患有冠心病的门诊患者为研究对象。2006年在中国内地31个省市自治区选择32家三级医院和32家二级医院,每家医院以研究启动时点起连续选择既往曾确诊冠心病的门诊患者50例。采用访谈形式收集患者信息,填写统一表格。主要分析患者阿司匹林的应用及医生处方情况。结果(1)在2781例门诊冠心病患者中,男性1914例,女性867例,年龄(65±10)岁;(2)门诊冠心病患者阿司匹林的服用率为83.6%,男性(85.1%)高于女性(80.4%,P〈0.01),随着年龄的增加,阿司匹林的服用率呈下降趋势(P〈0.05),不同省市协作医院间阿司匹林的服用率存在差异(P〈0.01),其中贵州省患者阿司匹林的服用率最低(64.2%),浙江省最高(97.8%);(3)门诊冠心病患者阿司匹林的处方率为90.4%,总计93.0%的医生处方剂量符合《阿司匹林在动脉硬化性心血管疾病中临床应用:中国专家共识(2005)》中建议使用的剂量(75~150mg/d),不同省市协作医院医生处方剂量存在差异,个别医院1/3的处方剂量低于75mg/d;(4)女性、高龄、月收入低、既往无经皮冠状动脉介入治疗史及冠心病病程长的门诊冠心病患者,阿司匹林的服用率低。结论我国内地门诊冠心病患者阿司匹林的总服用率为83.6%,但31个省市、64家医院间差异较大;各医院医生阿司匹林处方剂量间也存在很大差异,应在冠心病二级预防中引起足够重视。 | 刘军 赵冬 刘静 孙佳艺 Sidney C Smith Jr | 2009 | 中华内科杂志2009，48，10： | 23 |
| 2 | Comparison of sperm retrieval and reproductive outcome in azoospermic men with testicular failure and obstructive azoospermia treated for infertility显示文摘我们估计了精子检索和 intracytoplasmic 精子注射结果的率,包括构思的婴儿的新生的侧面,在有阴囊的失败的人。三 -- 经历了微解剖的阴囊的精子抽取的有阴囊的失败的 165 个人在这研究被包括。我们把他们的结果与 40 作比较为注射使用了施主精子由于的有阴囊的失败的人与妨碍的精子缺乏没有通过检索,和 146 个人经历了经皮的精子检索。在阴囊的失败的检索率是 41.4% ,并且结果比妨碍的精子缺乏低(100% ;调整机会比率:0.033;95% CI:0.007-0.164;P <0.001 ) 。在精子注射以后的实时出生率与施主精子相比在有阴囊的失败(19.9%) 的人是更低的(37.5% ;调整或:0.377 (95% CI:0.233-0.609, P <0.001 )) 并且妨碍的精子缺乏(34.2% ;调整或:0.403 (95% CI:0.241-0.676, P = 0.001 ) 。构思的婴儿的新生的参数不在这些组之中是显著地不同的。我们断定在检索上获得精子并且在 intracytoplasmic 精子注射(ICSI ) 以后完成实时出生的机会与阴囊的失败在人被减少。在精子注射不似乎被阴囊的失败否定地影响以后,婴儿的侧面怀孕了。 | Sandro C Esteves Christina Prudencio Bill Seol Sidney Verza jr Christopher Knoedler Ashok Agarwal | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 3 | 中国多省市急性冠状动脉综合征住院患者高胆固醇血症患病现况显示文摘目的了解中国多省市急性冠状动脉综合征(ACS)住院患者高胆固醇血症的患病、知晓及治疗现状。方法以2751例住院诊断的ACS患者为研究对象。2006年在中国31个省市自治区选择32家三级医院和32家二级医院,每家医院以研究启动时点起连续选择50例经住院诊断的ACS患者。为避免研究可能带来的干预影响,采用回顾形式收集已出院患者的病历,填写统一表格,分析患者高胆固醇血症的患病、院前知晓及治疗情况。结果(1)在调查的2751例ACS住院患者中,男性占68.8%(1893例),女性占31.2%(858例),平均年龄(65±11)岁;其中心电图ST段抬高心肌梗死占39.4%,非ST段抬高心肌梗死8.8%,不稳定性心绞痛占51.8%;既往有ACS病史者27.3%。(2)2751例ACS住院患者中19.6%伴有高胆固醇血症,女性(25.5%)高于男性(16.9%,P〈0.01);按地理区域分为7个地区(华北、华东、华南、华中、东北、西北和西南),其中华东地区患者高胆固醇血症患病率最高(24.7%),华中地区最低(10.0%),各地区间的差异具有统计学意义(P〈0.01)。(3)在540例高胆固醇血症患者中,入院前知晓率为12.2%,各地区间知晓率的差异具有统计学意义(P〈0.05);入院前高胆固醇血症的治疗率为8.2%,知晓者的治疗率为66.7%;治疗率最高的是华南地区(83.3%),最低是西南地区(0%)。(4)既往有ACS史的患者中高胆固醇血症的患病率为22.1%,知晓率为18.1%,治疗率为76.7%,上述三率均高于既往无ACS病史者(18.7%、9.7%、58.3%);其中仅有21.2%的患者胆固醇控制达标。结论ACS住院患者中近20%伴有高胆固醇血症;入院前高胆固醇血症知晓率为12.2%;治疗率为66.7%。既往有ACS史的高胆固醇血症患者仅有1/5控制达标,这在冠心病二级预防中应当引起重视。 | 刘军 赵冬 刘群 刘静 孙佳艺 Sidney C Smith Jr | 2009 | 中华心血管病杂志2009，37，5： | 6 |
| 4 | 冠心病介入治疗后血管闭合装置Angio-Seal^(TM)的临床应用显示文摘目的 评价在肝素联合强效抗血小板制剂GPⅡb Ⅲa受体拮抗剂应用的情况下 ,经皮穿刺冠状动脉介入治疗 (PCI)术后使用Angio SealTM的效果和患者的满意度。方法 本组 16 1例患者接受肝素、GPⅡb Ⅲa受体拮抗剂和常规PCI治疗 ,其中术后应用Angio SealTM(A组 ) 10 5例 ,Femostop(B组 ) 5 6例。观察两组术后止血时间、早期行走时间和血管并发症及电话随访出院后 4 8h患者的满意度 ,并进行统计学分析。结果 Angio SealTM应用成功率为 98.1%。两组术后止血时间分别是 (1.8± 2 .2 )min和 (12 9± 5 1)min (P <0 .0 0 0 1) ;术后早期开始行走时间分别为(6 .4± 2 .3)h和 (15 .2± 4 .8)h(P <0 .0 0 0 1)。A组出现 2例血肿 ,均保守治疗 ;B组分别有 3例血肿 ,2例假性动脉瘤和 1例动静脉瘘 ,其中 3例送外科手术 ;两组总血管并发症的发生率分别为 1.9%与 10 .7% (P <0 .0 5 )。术后住院时间分别为 (2 8.2± 10 .4 )h和 (5 8.4± 10 .2 )h(P <0 .0 0 0 1)。出院后 4 8h随访满意度两组分别为 93.3%和 6 0 .7% (P<0 .0 0 1)。结论 在需要强效抗凝的情况下 ,PCI术后应用Angio SealTM在即刻止血、早期行走和缩短住院时间方面均优于传统压迫方法 ,尤其是能显著降低血管并发症的发生率和提高患者的满意度。 | 李志忠 Sidney L Juergens C | 2004 | 北京医学2004，26，6： | 2 |
| 5 | ACC/AHA Guidelines for percutaneous coronary intervention 显示文摘 | Smith Jr James T | 2001 | Circulation2001，103，24： | 1 |
| 6 | A systematic assessment of MI-IC class II peptide binding predictions and evaluation of a consensus approach显示文摘 | WANG P SIDNEY J DOW C | 2008 | PLoS Comput Biol2008，4，： | 1 |
| 7 | Davis Aerosol particle charging by free electrons 显示文摘 | DAVIDD B O' HARA J SIDNEY CLEMENTS WRIGHT C FINNEY | 1989 | Journal of Aerosol Science1989，20，： | 1 |
| 8 | 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-- Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percu- taneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) : A Report of the American College of Cardi- ology Foundation/American Heart Association Task Force on Prac- tice Guidelines显示文摘 | Frederick G K Mary H Sidney C S | 2009 | JACC2009，54，23： | 1 |
| 9 | Association of hostility with coronary artery calcification in young adults: the CARD1A study显示文摘 | Iribarren C Sidney S Bild DE | 2000 | J AMA2000，283，19： | 1 |
| 10 | Calcification of the aortic arch: risk factor and association with coronary heart disease, stroke, and peripheral vascular disease 显示文摘 | Iribarren C Sidney S Sternfeld B | 2000 | JAMA2000，283，： | 1 |
| 11 | COPD and incident cardiovascular disease hospitalizations and mortality : Kaiser Per- manente Medical Care Program 显示文摘 | Sidney S Sorel M Quesenberry C J | 2005 | Chest2005，128，4： | 1 |
| 12 | Interpersonal relatedness, self-definition, and their motivational orientation during adolescence: A heorical and empirical integration显示文摘 | Shahar Golan Henrich Christopher C Blatt Sidney j | 2003 | Developmental Psychology2003，39，3： | 1 |
| 13 | 2009 Focused Updates:ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guide line and 2007 focused update) a report of the American College of Cardiology Foundation /American Heart Association Task Force on practice guidelines显示文摘 | Frederick G Kushner Mary Hand Sidney C Smith | 2009 | Circulation2009，，120： | 1 |
| 14 | A comparison of risk factors for recurrent TIA and stroke in patients diagnosed with TIA 显示文摘 | Johnston S C Sidney S Bernstein A C | 2003 | Neurology2003，60，： | 1 |
| 15 | ACC/AHA/SCA 2005 guideline update for percutaneous coronary intervention;a report of the American College of Cardiology/American Heart Association Task Force on Practice Guideline(ACC/AHA/SCA I Writing Committee to Update the 2001 Guideline for Percutaneous Coronary lntervention)显示文摘 | Sidney C Smith SC Jr Ted E el aI | 2006 | J Am CoU Cardiol2006，47，： | 1 |
| 16 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 17 | Ischemie stroke and use of estrogen and estrogen/proestrogen as hormone replacement therapy显示文摘 | Petitti D B Sidney S Quesenberry C P | 1998 | Stroke1998，29，： | 1 |
| 18 | Overcoming T cell tolerance to the hepatitis ]3 virus surface antigen in hepatitis B virus- transgenic mice 显示文摘 | Sette AD Oseroff C Sidney J | 2001 | J Immunol2001，166，2： | 1 |
| 19 | Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases显示文摘 | Iribarren C Jacobs DR Sidney S | 1998 | Epidemiol Infect1998，121，2： | 1 |
| 20 | Pullout resistance of individual longitudinal and transverse geogrid ribs 显示文摘 | Sidnei H C T Benedito S B Jorge G Z | 2007 | Journal of Geoteehnieal and Geoenvironmental Engineering2007，133，1： | 1 |
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