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| 1 | Pre-existing diabetes mellitus increases the risk of gastric cancer:A meta-analysis显示文摘AIM:To systematically assess the association between diabetes and incidence of gastric cancer.METHODS:We searched MedLine (PubMed),EMBASE,and the Cochrane Library without any limitations with respect to publication date or language,we also searched the references of qualifying articles.Casecontrol studies and cohort studies comparing the risk of gastric cancer between diabetic patients and control subjects were included.We excluded studies reporting only standardized incidence ratios without control groups and those that investigated only mortality but not incidence.Seventeen studies met our criteria,and the qualities of these studies were assessed using theNewcastle-Ottawa Quality Assessment Scale.We performed a meta-analysis of pre-existing diabetes and gastric cancer incidence using the DerSimonian-Laird method for random-effects.For subgroup analyses,we separated the studies by study type,region,sex and method to determine confounding factors and reliability.We also conducted subgroup analyses to examine the effects of smoking,Helicobacter pylori (H.pylori) infection,and cancer site.Publication bias was evaluated using Begg's test.RESULTS:A random-effects model meta-analysis showed an increased gastric cancer risk in diabetic patients [relative risk (RR)=1.19;95%CI:1.08-1.31].Subgroup analyses indicated that this result persisted in cohort studies (RR=1.20;95%CI:1.08-1.34),in studies on populations of both Western (RR=1.18;95%CI:1.03-1.36) and Eastern countries (RR=1.19;95%CI:1.02-1.38),in a female subgroup (RR=1.24;95%CI:1.01-1.52),and in highly qualified studies (RR=1.17;95%CI:1.05-1.31).Moreover,these results persisted when the analysis was confined to studies adjusted for well-known gastric cancer risk factors such as smoking (RR=1.17;95%CI:1.01-1.34) and H.pylori infection (RR=2.35;95%CI:1.24-4.46).CONCLUSION:Pre-existing diabetes mellitus may increase the risk of gastric cancer by approximately 19%.This effect seems to be unrelated to geographical region. | Jae Moon Yoon Ki Young Son Chun Sick Eom Daniel Durrance Sang Min Park | 2013 | World Journal of Gastroenterology2013，19，6： | 14 |
| 2 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 3 | WATCHMAN左心耳封闭系统用于房颤患者卒中预防的全球初步经验 | Sick P.B. Schuler G. Hauptmann K.E. 朱冰坡 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，8： | 3 |
| 4 | Arguments for an individualized closure of the pancreatic remnant after distal pancreatic resection显示文摘AIM:To analyze risk factors for postoperative pancreatic fistula(POPF) rate after distal pancreatic resection(DPR).METHODS:We performed a retrospective analysis of 126 DPRs during 16 years.The primary endpoint was clinically relevant pancreatic fistula.RESULTS:Over the years,there was an increasing rate of operations in patients with a high-risk pancreas and a significant change in operative techniques.POPF was the most prominent factor for perioperative morbidity.Significant risk factors for pancreatic fistula were high body mass index(BMI) [odds ratio(OR) = 1.2(CI:1.1-1.3),P = 0.001],high-risk pancreatic pathology [OR = 3.0(CI:1.3-7.0),P = 0.011] and direct closure of the pancreas by hand suture [OR = 2.9(CI:1.2-6.7),P = 0.014].Of these,BMI and hand suture closure were independent risk factors in multivariate analysis.While hand suture closure was a risk factor in the low-risk pancreas subgroup,high BMI further increased the fistula rate for a high-risk pancreas.CONCLUSION:We propose a risk-adapted and indication-adapted choice of the closure method for the pancreatic remnant to reduce pancreatic fistula rate. | Ulrich Friedrich Wellner Frank Makowiec Olivia Sick Ulrich Theodor Hopt Tobias Keck | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 3 |
| 5 | Single-Molecule Identification by Spectrally and Time-Resolved Fluorescence Detection 显示文摘 | Prummer M Hubner C G Sick B | 2000 | Anal Chem2000，72，3： | 2 |
| 6 | An immortalized cell line expresses properties of activated microglial cells显示文摘 | Bocchini V Mazzolla R Barluzzi R Blasi E Sick P Kettenmann H | 1992 | J Neurosci Res1992，31，4： | 2 |
| 7 | 水泵水轮机尾水管中涡带的研究显示文摘在部分负荷条件下,水泵水轮机尾水管的非稳定流态(即所谓的尾水管涡带)和它对转轮轴的影响已经通过雷诺应力紊流模型利用非稳态雷诺Navier-Stokes法进行了数值模拟。为了寻求尾水管涡带对转轮轴的瞬变力和扭矩的作用,计算域包含了全部转轮和尾水管。模拟流场的结果与转轮轴上的力、扭矩还有尾水管壁的壁而脉动的实验数据完全一致。尾水管中涡带引起的力、压力脉动的频率和幅值是设计水轮机转轮的重要信息,而这蝼可以通过CFD方法得到珲想的预测。 | Mirjam Sick 金东杰(译) 吴新润(校) | 2006 | 国外大电机2006，，1： | 2 |
| 8 | Long-Term Outcome after 92 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Comparison of Beger and Frey Procedures显示文摘 | Tobias Keck Ulrich Friedrich Wellner Hartwig Riediger Ulrich Adam Olivia Sick Ulrich Theodor Hopt Frank Makowiec | 2010 | Journal of Gastrointestinal Surgery2010，，3： | 2 |
| 9 | Ischemic Stroke Subtypes: A Population-Based Study of Functional Outcome, Survival, and Recurrence显示文摘 | George W. Petty Robert D. Brown Jack P. Whisnant JoRean D. Sicks W. Michael O’Fallon David O. Wiebers | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 2 |
| 10 | Effects on imaging diagnostics of hollowcone sprays显示文摘 | Sick V Stojkovic B | 2001 | Applied Optics2001，40，： | 1 |
| 11 | Stroke prevention technology for patients with non-valvular AF-wordwide experience with the new watchman LAA system显示文摘 | Sick PB Ulrich M Hauptmann C | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 12 | Stroke prevention in non-valvular atrial fibrillation:Long-term results after 6 years of the watchman left atrial appendage occlusion pilot study显示文摘 | Sick PB Turi Z Grube E | | European Heart Journal0，，： | 1 |
| 13 | High-speed imaging for direct-injection gasoline engine research and development显示文摘 | Volker Sick Michael C. Drake Todd D. Fansler | 2010 | Experiments in Fluids2010，，4： | 1 |
| 14 | Scanning near-field opti- cal microscopy with aperture probes:Fundamentals and applica- tions 显示文摘 | HECHT B SICK B WILD U P | 2000 | The Journal of Chemical Physics2000，112，18： | 1 |
| 15 | WNT and DKK determine hair foilicle spacing through a reaction - diffusion mechanism 显示文摘 | SICK S REINKER S TIMMER J | 2006 | Science2006，314，5804： | 1 |
| 16 | Tracer-LIF diagnostics:Quantitative measurement of fuel concentration,temperature and fuel /air ratio in practical combustion systems显示文摘 | Schulz C Sick V | 2005 | Progress in Energy and Combustion Science2005，31，1： | 1 |
| 17 | Hydrogen peroxide decomposition by a non -heme iron (Ⅲ) catalase mimic:a DFT study显示文摘 | Sicking W Korth H G Jansen G | 2007 | Chem Eur J2007，13，： | 1 |
| 18 | Compressplate fixation in actuediaphyscal fractures of the radius and ulna 显示文摘 | Anderson LD Sick TD Tooms RE | 1975 | J Bone Joint Surg(Am)1975，57，3： | 1 |
| 19 | Vascularizatiou of the adipose body of the cheek显示文摘 | Kahn JL Sick H Laude M | 1990 | Arch Anat Histol Embryol1990，73，： | 1 |
| 20 | The Marfan syndrome in early childood: analysis of 15 patients diag nosed at less than 4 years of ages显示文摘 | Sick HE Zahka KG Pyeritz RE | 1983 | Am J Cardiol1983，52，： | 1 |
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