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| 1 | Competition between human cells by entosis显示文摘人的癌由被知道为营养素和生长因素间接地竞争的肿瘤房间的复杂混合物组成。肿瘤房间是否能也直接竞争,例如由对手的消除,不被知道。这里,我们证明人的房间能直接由称为 entosis 的吞没的机制竞争。由 entosis,当时,房间被吞没,或吃活,并且随后经历房间死亡。我们发现吞没的身份(“ winner”) 并且吞没(“ loser”) 房间被 RhoA 和肌动球朊控制的机械 deformability 支配,有高 deformability 的肿瘤房间在此优先地吞没并且 outcompete 有在异构的人口的低 deformability 的附近的房间。我们进一步发现那激活的 Kras 并且 Rac 发信号由 downregulating 给予获胜者地位到房间可收缩的肌浆球蛋白,允许最后经历房间死亡的附近的房间的成为主观。最后,我们计算 cell-in-cell 形成的精力风景,表明那一机械在获胜者和输家房间之间微分被要求让 entosis 继续。这些数据在发生在人的肿瘤的哺乳动物的房间定义竞争的机制。 | Qiang Sun Tianzhi Luo Yixin Ren Oliver Florey Senji Shirasawa Takehiko Sasazuki Douglas N Robinson Michael Overholtzer | 2014 | Cell Research2014，24，11： | 8 |
| 2 | Expression and structure of senescence marker protein-30 (SMP-30) and its biological significance 显示文摘 | Fujita T Shirasawa T Maruyama N | 1999 | Mech Ageing Dev1999，107，3： | 2 |
| 3 | Reversible middle cerebral artery occlusion in rats using an intraluminal thread technique 显示文摘 | Kawamura S Li Y Shirasawa M Yasui N Fukasawa H | 1994 | Surg Neurol1994，41，： | 1 |
| 4 | Therapeutic effects of hyperbaric oxygenation on acute focal cerebral ischemia in rats显示文摘 | Kawamura S Yasui N Shirasawa M | 1990 | Surg Neurol1990，54，： | 1 |
| 5 | Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto' s thyroiditis to 8q23-q24 by multipoint affected sibpair linkage analysis in Japanese 显示文摘 | Sakai K Shirasawa S Ishikawa N | 2001 | Hum Mol Genet2001，10，： | 1 |
| 6 | Receptor for advanced glycation end-products is a marker of type I lung alveolar cells 显示文摘 | Shirasawa M Fujiwara N Hirabayashi S | 2004 | Genes Cells2004，9，2： | 1 |
| 7 | Expression and structure of senescence marker protein-30 (SMP30) and its biological signifi- cance 显示文摘 | Fujita T Shirasawa T Maruyama N | 1999 | Mech Age Develop1999，107，27： | 1 |
| 8 | High blood pres- sure in obese and nonobese Japanese children: Blood pressure meas- urement is necessary even in nonobese Japanese children 显示文摘 | SHIRASAWA T SHIMADA N OCHIAI H | 2010 | J Epi- demiol2010，20，5： | 1 |
| 9 | Rat middle cerebral artery occlusion using an intraluminal thread technique显示文摘 | Yasui N Shirasawa M | 1991 | Acta Neurochi1991，109，34： | 1 |
| 10 | Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sibpair linkage analysis in Japanese 显示文摘 | Sakai K Shirasawa S lshikawa N | 2001 | Hum Mol Genet2001，10，13： | 1 |
| 11 | Time se-ries observations of the structure and properties ofbrackish ice in the Gulf of Finland,the Baltic Sea显示文摘 | Kawamura T Shirasawa K Ishikawa N | 2001 | Annals of Glaciology2001，33，： | 1 |
| 12 | Rat middle cerebral artery occlusion using an intraluminal thread technique显示文摘 | Kawamura S Yasui N Shirasawa M | 1991 | Acta Neurochi1991，109，34： | 1 |
| 13 | Identification of susceptibility loci for autoimmune thyroid disease to 5q31-q33 and Hashimoto's thyroiditis to 8q23-q24 by multipoint affected sib-pair linkage analysis in Japanese显示文摘 | Sakai K Shirasawa S Ishikawa N | 2001 | Hum Mol Genet2001，10，13： | 1 |
| 14 | Therapeuatic Effects of Hyperbaric oxygenation on actue focal cerebral ischemia in rats显示文摘 | Kawamura S Yasui N Shirasawa M | 1990 | Surg Neurol1990，54，： | 1 |
| 15 | Identification of susceptibility loci for autoimmune thyroid disease to 5q31 - q33 and Hashimoto~ thyroiditis to 8@3 - @4 by multi- point affected sib -pair linkage analysis in Japanese 显示文摘 | Sakai K Shirasawa S Ishikawa N | 2001 | Hum Mol Genet2001，10，13： | 1 |
| 16 | Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction显示文摘 | Kubota Y Hashitani H Shirasawa N | 2007 | Neurourol Urodyn2007，27，8： | 1 |
| 17 | Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction显示文摘 | KUBOTA Y HASHITANI H SHIRASAWA N | 2008 | Neurourol Urodyn2008，27，4： | 1 |
| 18 | Therapeuatic effects of hyperbaric oxygenation on actue focal cerebral ischemia in rats显示文摘 | Kawamura S Yasui N Shirasawa M | 1990 | Surg Neurol1990，34，2： | 1 |
| 19 | Rat Middle Cerebral Artery Occlusion Using an Intraluminal Thread Technique显示文摘 | KAWAMURA S YASUI N SHIRASAWA M | 1991 | Acta Neurochi(S0942-0940)1991，109，34： | 1 |
| 20 | Receptor for advanced glycation end-products is a marker of type I lung alveolar ceils显示文摘 | Shirasawa M Fujiwara N Hirabayashi S | 2004 | Genes Ceils2004，9，： | 1 |
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