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| 1 | Enhanced mechanical properties and degradation rate of Mg-Ni-Y alloy by introducing LPSO phase for degradable fracturing ball applications显示文摘In this work,as-cast Mg-Ni-Y alloys were proposed to develop a feasible material for fracturing balls,and their mechanical performance and corrosion behavior were systematically investigated.Long period stacking order(LPSO)phase was firstly introduced to improve both the mechanical properties and degradation rate of magnesium alloys.With the increase of LPSO phase,the compressive strength was improved significantly,while the elongation of the alloys decreased owing to the relatively brittle nature of LPSO phase.Due to the higher corrosion potential of LPSO phase,the LPSO phase can accelerate the corrosion process by providing more micro-couples.However,the LPSO phase would serve as the corrosion barrier between the corrosion medium and the matrix when the contents of LPSO phase are too high in Mg92.5Ni3Y4.5 and Mg87.5Ni5Y7.5 alloys.As-cast Mg97.5Ni1Y1.5 alloy with satisfactory mechanical properties and rapid degradation rate was successfully developed,exhibiting a high degradation rate of 6675 mm/a(93℃)in 3 wt.%KCl solution and a favorable ultimate compressive strength of 410 MPa.The degradation rate of Mg97.5Ni1Y1.5 alloy is 2-5 times of the current commercial magnesium alloy fracturing materials. | Jingfeng Wang Shiqing Gao Xiuying Liu Xing Peng Kui Wang Shijie Liu Weiyan Jiang Shengfeng Guo Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 13 |
| 2 | Sciatic nerve regeneration using a nerve growth factor-containing fibrin glue membrane显示文摘Our previous findings confirmed that the nerve growth factor-containing fibrin glue membrane provides a good microenvironment for peripheral nerve regeneration;however,the precise mechanism remains unclear.p75 neurotrophin receptor(p75NTR)plays an important role in the regulation of peripheral nerve regeneration.We hypothesized that a nerve growth factor-containing fibrin glue membrane can promote neural regeneration by up-regulating p75NTRexpression.In this study,we used a silicon nerve conduit to bridge a 15 mm-long sciatic nerve defect and injected a mixture of nerve growth factor and fibrin glue at the anastomotic site of the nerve conduit and the sciatic nerve.Through RT-PCR and western blot analysis,nerve growth factor-containing fibrin glue membrane significantly increased p75NTRmRNA and protein expression in the Schwann cells at the anastomotic site,in particular at 8 weeks after injection of the nerve growth factor/fibrin glue mixture.These results indicate that nerve growth factor-containing fibrin glue membrane can promote peripheral nerve regeneration by up-regulating p75NTRexpression in Schwann cells. | Shengzhong Ma Changliang Peng Shiqing Wu Dongjin Wu Chunzheng Gao | 2013 | Neural Regeneration Research2013，8，36： | 4 |
| 3 | Novel lift enhancement method based on zero-mass-flux jets and its adaptive controlling laws design显示文摘For lessening the weight and volume of flow control system,enlarging the circulation control applying area of angle of attack(AOA),and achieving nice controlling characteristics,a novel lift enhancement method based on dual synthetic jet actuators(DSJAs)and synthetic jet actuator(SJA),and an adaptive proportional integral and differential(PID)algorithm based on radial basis function neural network are introduced.DSJAs are uniformly located along the chord to suppress the separation and trailing-edge SJA is applied to achieve the high circulation.Velocities of actuators are modulated to realize the real speed profile and on–off controlling laws of DSJAs are designed.Numerical simulations show that DSJAs and SJA could suppress the separation completely and move leading-edge stagnation point and trailing-edge separation point downstream even at AOA of 19°,hence achieve the highest lift and nose-down moment augmentation(ΔCl_(max)=0.92,ΔCm_(max)=0.02534),andΔL/D can reach 11.39 at AOA of 18°.Stalling is delayed to more than 19°.Linear lift area and pitch-break angle are both increased to 16°.ΔCl/C_(μ) can reach 76.7,indicating the greatest control efficiency.The results of adaptive PID control,whose controlling effects are proved better than PID,indicate that lift could track the objective with the rise time of 0.0325 s and finally keep steady,suggesting the nice stability and rapidness. | Zhijie Zhao Zhenbing Luo Bin Xu Xiong Deng Yuyan Guo Wenqiang Peng Shiqing Li | 2021 | Acta Mechanica Sinica2021，37，10： | 3 |
| 4 | UPF1 increases amino acid levels and promotes cell proliferation in lung adenocarcinoma via the eIF2α-ATF4 axis显示文摘Up-frameshift 1(UPF1),as the most critical factor in nonsense-mediated messenger RNA(mRNA)decay(NMD),regulates tumor-associated molecular pathways in many cancers.However,the role of UPF1 in lung adenocarcinoma(LUAD)amino acid metabolism remains largely unknown.In this study,we found that UPF1 was significantly correlated with a portion of amino acid metabolic pathways in LUAD by integrating bioinformatics and metabolomics.We further confirmed that UPF1 knockdown inhibited activating transcription factor 4(ATF4)and Ser51 phosphorylation of eukaryotic translation initiation factor 2α(eIF2α),the core proteins in amino acid metabolism reprogramming.In addition,UPF1 promotes cell proliferation by increasing the amino-acid levels of LUAD cells,which depends on the function of ATF4.Clinically,UPF1 mRNA expression is abnormal in LUAD tissues,and higher expression of UPF1 and ATF4 was significantly correlated with poor overall survival(OS)in LUAD patients.Our findings reveal that UPF1 is a potential regulator of tumor-associated amino acid metabolism and may be a therapeutic target for LUAD. | Lei FANG Huan QI Peng WANG Shiqing WANG Tianjiao LI Tian XIA Hailong PIAO Chundong GU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，10： | 2 |
| 5 | Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs显示文摘Endothelial NO synthase (eNOS) expression is regulated by a number of transcriptional and post-transcriptional mechanisms, but the effects of competing endogenous RNAs (ceRNAs) on eNOS mRNA and the underlying mechanisms are still unknown. Our bioinformatic analysis revealed three highly expressed eNOS-targeting miRNAs (miR-15b, miR-16, and miR-30b) in human endothelial cells (ECs). Among the 1103 mRNA targets of these three miRNAs, 15 mRNAs share a common disease association with eNOS. Gene expression and correlation analysis in patients with cardiovascular diseases identified insulin receptor substrate 2 (IRS2) as the most correlated eNOS-ceRNA. The expression levels of eNOS and IRS2 were coincidentally increased by application of laminar shear but reduced with eNOS or IRS2 siRNA transfection in human ECs, which was impeded by Dicer siRNA treatment. Moreover, luciferase reporter assay showed that these three miRNAs directly target the 3′UTR of eNOS and IRS2. Overexpression of these three miRNAs decreased, whereas inhibition of them increased, both mRNA and protein levels of eNOS and IRS2. Functionally, silencing eNOS suppressed the Akt signal pathway, while IRS2 knockdown reduced NO production in ECs. Thus, we identified eNOS and IRS2 as ceRNAs and revealed a novel mechanism explaining the coincidence of metabolic and cardiovascular diseases. | Xiaoli Sun Huizhen Lv Peng Zhao Jinlong He Qinghua Cui Minxin Wei Shiqing Feng Yi Zhu | 2019 | Journal of Molecular Cell Biology2019，11，6： | 2 |
| 6 | Prevalence and associated metabolic factors of fatty liver disease in the elderly显示文摘 | Zhongli Wang Ming Xu Jianhong Peng Li Jiang Zhengguo Hu Hua Wang Shiqing Zhou Rui Zhou Michael Hultstr?m En Yin Lai | 2013 | Experimental Gerontology2013，，8： | 2 |
| 7 | HbMyb1,a Myb transcription factor from Hevea brasiliensis,suppresses stress in-duced cell death in transgenic tobacco显示文摘 | Peng Shiqing Wu Kunxin Huang Guixiu | 2011 | Plant Physiology and Biochemistry2011，49，12： | 1 |
| 8 | Improving the quality of acute pain services: experiences of treatment of 5212 patients显示文摘 | Shiqing L Kangqing X Peng Y | 2009 | Anestez jol Intens Ter2009，41，4： | 1 |
| 9 | Tuning electronic configuration of WP_(2) nanosheet arrays via nickel doping for high-efficiency hydrogen evolution reaction显示文摘Modulate the electronic structure and surface energy by nanostructure and heteroatom doping is an efficient strategy to improve electrocatalytic activity of hydrogen evolution reaction(HER).Herein,nickel incorporated WP_(2) self-supporting nanosheet arrays cathode was synthesized on carbon cloth(Ni-WP_(2) NS/CC)by in-situ phosphating reduction of the Ni-doped WO3.It shows that heteroatom doping and the three-dimensional(3D)nanosheet arrays morphology both facilitate to reduce the interfacial transfer resistance and increase electrochemical-active surface areas,which effectively improve electrocatalytic hydrogen evolution reaction(HER)activity.The optimized catalyst,1%Ni-WP_(2) NS/CC,exhibits an outstanding electrocatalytic performance with an overpotential of 110 m V at 10 m A cm^(-2) and a Tafel slope of 65 m V dec^(-1) in the acid solution.DFT calculations further demonstrate the nickel doping can adjust the intrinsic structure of electronics,lower the Gibbs free energy of adsorption of hydrogen(DGH*),and effectively improve the HER performance. | Wei Liu Peng Geng Shiqing Li Wenhui Liu Dayong Fan Huidan Lu Zhenhuan Lu Yongping Liu | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 10 | Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1-Notch1显示文摘Cardiac-resident macrophages(CRMs)play important roles in homeostasis,cardiac function,and remodeling.Although CRMs play critical roles in cardiac regeneration of neonatal mice,their roles are yet to be fully elucidated.Therefore,this study aimed to investigate the dynamic changes of CRMs during cardiac ontogeny and analyze the phenotypic and functional properties of CRMs in the promotion of cardiac regeneration.During mouse cardiac ontogeny,four CRM subsets exist successively:CX3CR1+CCR2-Ly6C-MHCII-(MP1),CX3CR1lowCCR2lowLy6C-MHCII-(MP2),CX3CR1-CCR2+Ly6C+MHCII-(MP3),and CX3CR1+CCR2-Ly6C-MHCII+(MP4).MP1 cluster has different derivations(yolk sac,fetal liver,and bone marrow)and multiple functions population.Embryonic and neonatal-derived-MP1 directly promoted cardiomyocyte proliferation through Jagged-1-Notch1 axis and significantly ameliorated cardiac injury following myocardial infarction.MP2/3 subsets could survive throughout adulthood.MP4,the main population in adult mouse hearts,contributed to inflammation.During ontogeny,MP1 can convert into MP4 triggered by changes in the cellular redox state.These findings delineate the evolutionary dynamics of CRMs under physiological conditions and found direct evidence that embryonic and neonatal-derived CRMs regulate cardiomyocyte proliferation.Our findings also shed light on cardiac repair following injury. | Rong Chen Shiqing Zhang Fang Liu Lin Xia Chong Wang Siamak Sandoghchian Shotorbani Huaxi Xu Subrata Chakrabarti Tianqing Peng Zhaoliang Su | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 1 |
| 11 | Association of decreased expression of a Myb transcription factor with the TPD (tapping panel dryness) syndrome in Hevea brasiliensis 显示文摘 | SHOUCAI CHEN SHIQING PENG GUIXIU HUANG | 2003 | Plant Molecular Biology2003，51，1： | 1 |
| 12 | Improving the quality of acute pain services:experiences of treatment of 5212 patients显示文摘 | Shiqing L Kangqing X Peng Y | | Anestezjol Intens Ter0，，： | 1 |
| 13 | Improving hole transfer of boron nitride quantum dots modified PDI for efficient photodegradation显示文摘In recent years,organic photocatalyst under visible-light absorption has shown significant potential for solving environmental problems.However,it is still a great challenge for constructing a highly active organic photocatalyst due to the low separation efficiency of photogenerated carriers.Herein,an effective and robust photocatalyst perylene-3,4,9,10-tetracarboxylic diamide/boron nitride quantum dots(PDI/BNQDs),consisting of selfassemble PDI withπ–πstacking structure and BNQDs,has been constructed and researched under visible light irradiation.The PDI/BNQDs composite gradually increases organic pollutant photodegradation with the loading amount of BNQDs.With 10 mL of BNQDs solution added(PDI/BNQDs-10),the organic pollutant photodegradation performance reaches a maximum,about 6.16 times higher with methylene blue and 1.68 times higher with ciprofloxacin than that of pure PDI supramolecular.The enhancement is attributed to improved separation of photogenerated carriers from self-assembled PDI by BNQDs due to their preeminent ability to extract holes.This work is significant for the supplement of PDI supramolecular composite materials.We believe that this photocatalytic design is capable of expanding organic semiconductors’potential for their applications in photocatalysis. | Shiqing Ma Chundong Peng Zeyu Jia Yanmei Feng Kai Chen Hao Ding Daimei Chen Zhong-Yong Yuan | 2023 | Frontiers of Chemical Science and Engineering2023，17，11： | 0 |
| 14 | Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development显示文摘The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen development.The transcription factors (TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1,a gatekeeper TF in the tapetum.Nevertheless,the regulatory mechanisms governing the activity of bHLH010/089/091 remain unknown.In this study,we reveal that caffeoyl coenzyme A O-methyltransferase 1 (CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089,probably through their K259 site.Our findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and bHLH089.Intriguingly,elevated CCoAOMT1 expression resulted in defective pollen development,mirroring the phenotype observed in bhlh010 bhlh089 mutants.Moreover,our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by CCoAOMT1.Importantly,transgenic plants with the probHLH089::bHLH089^(K259A)construct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 mutants.Collectively,these findings emphasize the need to maintain balanced TF homeostasis for male fertility.They firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development. | Zesen Lai Jianzheng Wang Ying Fu Menghan Wang Hong Ma Shiqing Peng Fang Chang | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 15 | Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms显示文摘Background and purpose Light transmission aggregometry(LTA)and CYP2C19 genotype analysis are commonly used to evaluate the antiplatelet effects of clopidogrel during the interventional treatment of intracranial aneurysms.The aim of this study was to determine which test can predict ischaemic events during these treatments.Methods Patient demographic information,imaging data,laboratory data and ischaemic complications were recorded.LTA and CYP2C19 genotype results were compared,and multiple linear regression was performed to examine factors related to platelet reactivity.Multivariate regression analysis was performed to determine whether LTA and CYP2C19 could predict ischaemic complications and to identify other clinical risk factors.Receiver operating characteristic curve analysis was conducted to calculate the cut-off value for predicting ischaemic complications.A subgroup analysis was also performed for different CYP2C19 genotype metabolisers,as well as for patients with flow diverters and traditional stents.Results A total of 379 patients were included,of which 22 developed ischaemic events.Maximum platelet aggregation induced by ADP(ADP-MPA)could predict ischaemic events(p<0.001;area under the curve,0.752(95%CI 0.663 to 0.842)),and its cut-off value was 41.5%.ADP-MPA(p=0.001)and hypertension duration>10 years(p=0.022)were independent risk factors for ischaemic events,while the CYP2C19 genotype was not associated with ischaemic events.In the subgroup analysis,ADP-MPA could predict ischaemic events in fast metabolisers(p=0.004)and intermediate metabolisers(p=0.003).The cut-off value for ischaemic events was lower in patients with flow diverters(ADP-MPA=36.4%)than in patients with traditional stents(ADP-MPA=42.9%).Conclusions ADP-MPA can predict ischaemic complications during endovascular treatment of intracranial aneurysms.Patients with flow diverters require stronger antiplatelet medication than patients with traditional stents. | Yangyang Zhou Wenqiang Li Chao Wang Ruhang Xie Yongnan Zhu Qichen Peng Limin Zhang Hongqi Zhang Yuxiang Gu Shiqing Mu Jian Liu Xinjian Yang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
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