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| 1 | Diabetes mellitus carries a risk of gastric cancer:A metaanalysis显示文摘AIM:To investigate the association and quantify the relationship between diabetes mellitus(DM) and gastric cancer(GC) by an updated meta-analysis.METHODS:The initial PubMed search identified 1233publications. Studies not reporting GC or those not reporting actual number of GC were excluded. Twelve pertinent studies were retrieved from the PubMed database or from a manual search and considered for the meta-analysis. Pooled risk ratios and 95%CI were estimated by a random-effects model. Subgroup analysis was performed according to gender or geographical regions. Heterogeneity and publication bias were evaluated by I2and funnel plot analysis,respectively.RESULTS:DM was significantly associated with GC with a RR of 1.41(P = 0.006)(95%CI:1.10-1.81).Subgroup analyses revealed that both sexes showed a significant association with GC,with a greater magnitude of risk in females(RR = 1.90; 95%CI:1.27-2.85;P = 0.002) than in males(RR = 1.24; 95%CI:1.08-1.43;P = 0.002). In addition,the link between DM and GC was significant in East Asian DM patients(RR = 1.77;95%CI:1.38-2.26; P < 0.00001) but not in Western DM patients(RR = 1.23; 95%CI:0.90-1.68; P = 0.2).There was no evidence of publication bias,but the results indicated significant heterogeneity.CONCLUSION:This updated meta-analysis has provided evidence of positive DM-GC associations. The limited information on potentially important clinical confounding factors in each study deserves further investigation. | Shouji Shimoyama | 2013 | World Journal of Gastroenterology2013，19，40： | 11 |
| 2 | Stool antigen tests for the management of Helicobacter pylori infection显示文摘Stool antigen tests(SATs)are noninvasive diagnostic modules for Helicobacter pylori(H.pylori)infection.Two types of SATs exist for the diagnosis of H.pylori infection,one based on enzyme immunoassay(EIA)and another on immunochromatography(ICA).SATs do not require expensive chemical agents or specified equipment;hence,they are less expensive compared with the urea breath test.Both European and Japanese guidelines have shown that EIA-based SATs using monoclonal antibodies are useful for primary diagnosis as well as for the assessment of eradication therapy.ICA-based tests do not require particular equipment and are therefore useful in developing countries.SATs are also useful for the diagnosis of H.pylori infection in children and post gastric surgery patients.SATs performed via EIA can assess H.pylori infection in a large number of subjects,almost as well as serology.Thus,SATs would be useful or detecting current infection in such a survey to identify and eradicate H.pylori infection.The accuracy of SATs is lower when the stool samples are unformed or watery,because H.pylorispecific antigens in the stool samples are diluted.Temperature and the interval between stool sample collection and measurement also affect the results of SATs.The choice of test kit depends on the sensitivity and specificity in each region and the circumstances of each patient. | Tadashi Shimoyama | 2013 | World Journal of Gastroenterology2013，19，45： | 8 |
| 3 | Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test显示文摘AIM: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration. RESULTS: Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A450/630) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099). | Masaaki Kodama Kazunari Murakami Tadayoshi Okimoto Yoshihiro Fukuda Tadashi Shimoyama Masumi Okuda Chieko Kato Intetsu Kobayashi Toshio Fujioka | 2012 | World Journal of Gastroenterology2012，18，1： | 7 |
| 4 | Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous显示文摘瞄准:在活跃的煽动性的肠疾病(IBD ) 调查冷沉纤维蛋白(CF ) 的角色。方法:CF 是在 284 个题目的 assayed:61 与活跃并且 63 与不活跃的 ulcerative (UC ) , 45 有 proctocolectomy, 35 与活跃并且 20 与不活跃的 Crohn 的疾病(CD ) , 40 与另外的疾病和 20 健康控制。胰岛素禁止者(TI ) 和 TI 抗体(TI-Ab ) 被 ELISA 在血浆和 CF 建筑群测量。结果:在活跃 UC 的 CF 与所有另外的组(c2<0.001 ) 相比惊人地高。同样, CF 比在不活跃的 CD 或在控制(c2<0.01 ) 在活跃 CD 是显著地更高的。在 UC,高 CF 和 TI-Ab 与对操作的需要被联系。进一步,在血浆的高 CF, CF/fibrinogen 比率,低 TI 和高 TI-Ab 与疾病活动或倔强被联系到药。提高的 CF 没与相似 C 反应的蛋白质和白血房间除了红细胞沉降率数的尖锐反应物被联系,建议那提高的 CF 不是急性炎的后果。结论:在活跃 IBD 的提高的 CF 看起来是致病。CF 经由二主要机制支持 IBD, TI (一种反煽动性的物质) 熄灭并且损害由形成蛋白质总数的微脉管的灌注。CF 可以也用作长期的 IBD 的一个简历标记。另外的研究被保证充分在 IBD 评估 CF 的角色,结果应该贡献 IBD 的致病的更好的理解。 | Koji Sawada Ryouki Takahashi Abbi R Saniabadi Maiko Ohdo Takashi Shimoyama | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 5 | Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘 | Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori | 2004 | Journal of Gastroenterology2004，，9： | 2 |
| 6 | Predictability of in vivo ch-emosensitivity by in vitro MTT assay with reference to the clonogen-icassay显示文摘 | Shimoyama Y Kubota T Watanabe M | 1989 | J Surg Oncol1989，41，1： | 2 |
| 7 | Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma显示文摘 | Minato K Watanabe S | 1979 | Jpn J Clin Oncol1979，，： | 1 |
| 8 | ESR detection of wheat flour before and after irradiation显示文摘 | Shimoyama Y Ukai M Nakamura H | 2006 | Spectrochimica Acta Part A2006，63，4： | 1 |
| 9 | Indications of a minimized scope of lymphadenectomy for submucosal gastric cancer 显示文摘 | Shimoyama S Yasuda H Mafune K | 2002 | Ann Surg Oncol2002，9，7： | 1 |
| 10 | Percutaneous vertebroplasty immediatelyrelieves pain of osteoporotie vertebral com-pression fractures and prevents prolongedimnobilization of patients显示文摘 | Kobayashi K Shimoyama K Nakamura K eta1 | 2005 | Eur Radiol2005，15，2： | 1 |
| 11 | ABC screening for gastric cancer is not applicable in a Japanese population with high prevalence of atrophic gastritis显示文摘 | Shimoyama T Aoki M Sasaki Y | | 0，，03： | 1 |
| 12 | Clay minerals and petroleumforming reactions during burial and diagenesis显示文摘 | JOHNS W D SHIMOYAMA A | 1972 | AAPG Bulletin1972，56，11： | 1 |
| 13 | The CD8+ dendritic cell subset selectively enddocytoses dying cell in culture and in vivo 显示文摘 | Shimoyama S Kang L | 2002 | J Exp Med2002，195，10： | 1 |
| 14 | Increased serum angiogenin concentration in colorectal cancer is correlated with cancer progression显示文摘 | Yamasaki K Kawahara M | 1999 | Clin Cancer Res1999，5，5： | 1 |
| 15 | Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria显示文摘 | Fukuda S Shimoyama T | 2004 | J Gastroenterol2004，39，9： | 1 |
| 16 | Fragment-specific actionsof parathyroid hormone in isolated perfused rat hearts显示文摘 | Shimoyama M Ogino K Uchida K | 2001 | Calcif Tissue Int2001，69，2： | 1 |
| 17 | Granulocytic sarcoma of megakaryoblastic differentiation in the lymph nodes terminating as acute megakaryoblastic leukemia in a case of chronic idiopathic myelofibrosis persisting for 16 years显示文摘 | Hirose Y Masaki Y Shimoyama K | 2001 | Eur J Haematol2001，67，3： | 1 |
| 18 | Aprotinin attenuated ischemia reperfusion injury in an isolated rat lung model after 18-hours preservation显示文摘 | Shimoyama T Tabuchi N Kojima K | 2005 | Eur J Cardiothorac Surg2005，28，： | 1 |
| 19 | Dynamics of a Microflight MechanismWith MagneticRotational Wings in an Alternating Mag- netic Field 显示文摘 | Norihisa Miki Isao Shimoyama | 2002 | Joumal Of Micro electromechanical Systems2002，1011，5： | 1 |
| 20 | Peripheral odontogenic keratocyst: a report of 2 cases 显示文摘 | Ide F Shimoyama T Horie N | 2002 | J Periodontol2002，73，9： | 1 |
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