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| 1 | Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant显示文摘We report a case of fatal liver failure due to reactivation of lamivudine-resistant HBV. A 53-year-old man was followed since 1998 for HBV-related chronic hepatitis. Serum HBV-DNA was 150 MEq/mL (branched DNA signal amplification assay) and ALT levels fluctuated between 50-200 IU/L with no clinical signs of liver cirrhosis. Lamivudine (100 mg/d) was started in May 2001 and serum HBV-DNA subsequently decreased below undetectable levels. In May 2002, serum HBV-DNA had increased to 410 MEq/mL, along with ALT flare (226 IU/L). The YMDD motif in the DNA polymerase gene had been replaced by YIDD. Lamivudine was continued and ALT spontaneously decreased to the former levels. On Oct 3 the patient presenting with general fatigue, nausea and jaundice was admitted to our hospital. The laboratory data revealed HBV reactivation and liver failure (ALT: 1828 IU/L, total bilirubin: 10 mg/dL, and prothrombin INR: 3.24). For religious reasons, the patient and his family refused blood transfusion, plasma exchange and liver transplantation. The patient died 10 d after admission. The autopsy revealed remarkable liver atrophy. | Tatehiro Kagawa Norihito Watanabe Hisashi Kanouda Ichiro Takayama Tadahiko Shiba Takashi Kanai Kazuya Kawazoe Shinji Takashimizu Nobue Kumaki Kazuo Shimamura Shohei Matsuzaki Tetsuya Mine | 2004 | World Journal of Gastroenterology2004，10，11： | 10 |
| 2 | ELECTRONIC STATES AND HYDROGEN EMBRITTLEMENTIN TRANSITION METALS显示文摘An electronic approach to the mechanism of hydrogen embrittlement in metals is pre-sented and discussed. Some problems of the mechanism of hydrogen embrittlement are pointed out from an electronic point of view. Electronic structure calculations in a periodically cleaved or slipped lattice are developed in orker to identofy deformation-sensitive electronic states in the absence of hydrogen. The calculational results are given and discussed for a trunsition metal, Pd. Electronic structure calculations in the presence of hydrogen are outlined and hydrogen embrittlement in transition metals is discussed in terms of electronic states. | S. Tanimori and S. Shimamura(Department of Applied Science, Faculty of Engineering, Yamaguchi University, Ube 755, Japan) | 1997 | Acta Metallurgica Sinica(English Letters)1997，10，3： | 6 |
| 3 | Endoscopic diagnosis and treatment of early esophageal squamous neoplasia显示文摘Esophageal cancer is one of the leading causes of cancer-related death and is associated with high morbidity and mortality.It carries a poor prognosis as more than half of patients present with advanced and unresectable disease.One contributing factor is the increased risk of lymph node metastases at early stages of disease.As such,it is essential to detect squamous cell neoplasia (SCN) at an early stage.In order to risk stratify lesions,endoscopists must be able to perform image enhanced endoscopy including magnification and Lugol's chromoendoscopy.The assessment of both the horizontal extent and depth of any lesion is also of utmost importance prior to treatment.Endoscopic mucosal resection and submucosal dissection remain the standard of care with literature supportive their respective use.Radiofrequency ablation and other endoscopic treatments are currently available although should not be considered first line at this time.Our objective is to review the current options for the endoscopic diagnosis and treatment of esophageal SCN. | Yuto Shimamura Takashi Ikeya Norman Marcon Jeffrey D Mosko | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 5 |
| 4 | Repeat endoscopic submucosal dissection for recurrent gastric cancers after endoscopic submucosal dissection显示文摘AIM:To clarify the safety and efficacy of repeat endoscopic submucosal dissection(re-ESD)for locally recurrent gastric cancers after ESD.METHODS:A retrospective evaluation was performed of the therapeutic efficacy,complications and followup results from ESD treatment for early gastric cancers in 521 consecutive patients with 616 lesions at St.Luke`s International Hospital between April 2004 and November 2012.In addition,tumor size,the size of resected specimens and the operation time were compared between re-ESD and initial ESD procedures.A flex knife was used as the primary surgical device and a hook knife was used in cases with severe fibrosis in the submucosal layer.Continuous variables were analyzed using the non-parametric Mann-Whitney U test and are expressed as medians(range).Categorical variables were analyzed using a Fisher’s exact test and are reported as proportions.Statistical significance was defined as a P-value less than 0.05.RESULTS:The number of cases in the re-ESD group and the initial ESD group were 5 and 611,respectively.The median time interval from the initial ESD to re-ESD was 14(range,4-44 mo).En bloc resection with free lateral and vertical margins was successfully performed in all re-ESD cases without any complications.No local or distant recurrence was observed during the median follow-up period of 48(range,11-56 mo).Tumor size was not significantly different between the re-ESD group and the initial ESD group(median 22 mm vs 11mm,P=0.09),although the size of resected specimens was significantly larger in the re-ESD group(median 47 mm vs 34 mm,P<0.05).There was a nonsignificant increase observed in re-ESD operation time compared to initial ESD(median 202 min vs 67 min,respectively,P=0.06).CONCLUSION:Despite the low patient number and short follow-up,the results suggest that re-ESD is a safe and effective endoscopic treatment for recurrent gastric cancer after ESD. | Yuto Shimamura Naoki Ishii Kaoru Nakano Takashi Ikeya Kenji Nakamura Koichi Takagi Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，12： | 5 |
| 5 | Endoscopic naso-pancreatic drainage for the treatment of pancreatic fistula occurring after LDLT显示文摘Pancreatic fistula is a quite rare complication in patients who undergo living donor liver transplantation(LDLT).However,in the cases that show pancreatic fistula,the limited volume of the graft and the resultant inadequate liver function may complicate the management of the fistula.As a result,the pancreatic fistula may result in the death of the patient.We present 2 cases in whichendoscopic treatment was effective against pancreatic fistulas that developed after LDLT.In case 1,a 61-yearold woman underwent LDLT for primary biliary cirrhosis.Because of a portal venous thrombus caused by a splenorenal shunt,the patient underwent portal vein reconstruction,and a splenorenal shunt was ligated on postoperative day(POD)7.The main pancreatic duct was injured during the manipulation to achieve hemostasis,thereby necessitating open drainage.However,discharge of pancreatic fluid continued even after POD 300.Endoscopic naso-pancreatic drainage(ENPD)was performed,and this procedure resulted in a remarkable decrease in drain output.The refractory pancreatic fistula healed on day 40 after ENPD.In case 2,a 58-year-old man underwent LDLT for cirrhosis caused by the hepatitis C virus.When the portal vein was exposed during thrombectomy,the pancreatic head was injured,which led to the formation of a pancreatic fistula.Conservative therapy was ineffective;therefore,ENPD was performed.The pancreatic fistula healed on day 38 after ENPD.The findings in these 2 cases show that endoscopic drainage of the main pancreatic duct is a less invasive and effective treatment for pancreatic fistulas that develop after LDLT. | Akihisa Nagatsu Toshiya Kamiyama Satoru Todo Masahiko Taniguchi Tomomi Suzuki Hiroyuki Furukawa Tsuyoshi Shimamura Kenichiro Yamashita Hiroshi Kawakami Daisuke Abo | 2011 | World Journal of Gastroenterology2011，17，30： | 5 |
| 6 | Shape of Barrett's epithelium is associated with prevalence of erosive esophagitis显示文摘AIM:To test the hypothesis that the shape and length of Barrett's epithelium are associated with prevalence of erosive esophagitis.METHODS:A total study population comprised 869 patients who underwent endoscopy during a health checkup at our hospital.The presence and extent of Barrett's epithelium were diagnosed based on the Prague C & M Criteria.We originally classified cases of Barrett's epithelium into two types based on its shape,namely,flamelike and lotus-like Barrett's epithelium,and into two groups based on its length,its C extent < 2 cm,and ≥ 2 cm.Correlation of shape and length of Barrett's epithelium with erosive esophagitis was examined.RESULTS:Barrett's epithelium was diagnosed in 374 cases(43%).Most of these were diagnosed as shortsegment Barrett's epithelium.The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium,and in those with a C extent of ≥ 2 cm than < 2 cm.CONCLUSION:Flame-like rather than lotus-like Barrett's epithelium,and Barrett's epithelium with a longer segment were more strongly associated with erosive esophagitis. | Tomoyuki Akiyama Masahiko Inamori Hiroshi Iida Hiroki Endo Kunihiro Hosono Yasunari Sakamoto Koji Fujita Masato Yoneda Hirokazu Takahashi Tomoko Koide Chikako Tokoro Ayumu Goto Yasunobu Abe Takeshi Shimamura Noritoshi Kobayashi Kensuke Kubota Satoru Saito Atsushi Nakajima | 2010 | World Journal of Gastroenterology2010，16，4： | 4 |
| 7 | A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells显示文摘 | Toshiaki Teratani Kengo Tomita Takahiro Suzuki Tetsuya Oshikawa Hirokazu Yokoyama Katsuyoshi Shimamura Susumu Tominaga Sadayuki Hiroi Rie Irie Yoshikiyo Okada Chie Kurihara Hirotoshi Ebinuma Hidetsugu Saito Ryota Hokari Kazuo Sugiyama Takanori Kanai Soich | 2012 | Gastroenterology2012，，1： | 2 |
| 8 | Cause and Management of Recurrent Primary Spontaneous Pneumothorax After Thoracoscopic Stapler Blebectomy显示文摘 | Takashi Muramatsu Mie Shimamura Motohiko Furuichi Tatsuhiko Nishii Shinji Takeshita Shinichiro Ishimoto Hiroaki Morooka Yoko Tanaka Chiyoshi Yagasaki Kazumitsu Ohmori Motomi Shiono | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 9 | Determination of a new H+ -K+ ATPase inhibitor (E3810) and its four metabolites in human plasma by high-performance liquid chromatography 显示文摘 | Nakai H Shimamura Y Kanazawa T | 1994 | J Chromatogr B Biomed Appl1994，660，1： | 2 |
| 10 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 11 | Perioperative Management of Hepatic Resection Toward Zero Mortality and Morbidity: Analysis of 793 Consecutive Cases in a Single Institution显示文摘 | Toshiya Kamiyama Kazuaki Nakanishi Hideki Yokoo Hirofumi Kamachi Munenori Tahara Kenichiro Yamashita Masahiko Taniguchi Tsuyoshi Shimamura Michiaki Matsushita Satoru Todo | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 12 | Acute subdural hematoma caused by anemysmal rupture : incidence and clinical features 显示文摘 | Ohkuma H Shimamura N Fujita S | 2003 | Cerebrovasc Dis2003，16，： | 1 |
| 13 | Seminal vesicle cyst associated with contralateral renal agenesis : a case report 显示文摘 | Shimamura M Koizumi H Hisazumi H | 1984 | Hinyokika Kiyo1984，30，9： | 1 |
| 14 | Radiation dose reduction in hepatic multidetector computed tomography with a novel adaptive noise reduction filter显示文摘 | Yoshinori Funama Kazuo Awai Osamu Miyazaki Taiga Goto Yoshiharu Nakayama Masamitchi Shimamura Kumiko Hiraishi Shinichi Hori Yasuyuki Yamashita | 2008 | Radiation Medicine2008，，3： | 1 |
| 15 | Antimutagenic activity of(+)-β-eudesmol and paeonol from dioscorea japonica 显示文摘 | Miyazawa M Shimamura H Nakamura S | 1996 | Journal of Agricultural and Food Chemistry1996，44，7： | 1 |
| 16 | Bifidobactena: research and develop- ment in Japan显示文摘 | ISHIBASHI N SHIMAMURA S | 1993 | Food Teehnol1993，47，6： | 1 |
| 17 | Childhood idiopathic thrombocytopenic purpura associated with human parvovirus B19 infection显示文摘 | Hida M Shimamura Y Ueno E Watanabe J | 2000 | Pediatr Int2000，42，6： | 1 |
| 18 | Dynamics of a discoordination game with classical and quantum correlations显示文摘 | SHIMAMURA J MORIKOSHI F IMOTO N | 2004 | Phys Lett A2004，333，： | 1 |
| 19 | Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase显示文摘 | Shimamura M Matsuda M Yasumo H | 2007 | Arterioscler Thromb Vasc Biol2007，27，2： | 1 |
| 20 | Morphology and structure of highly elastic poly(vinyl alcohol) hydrogel prepared by repeated freezing-and-melting显示文摘 | Yokoyama F Masada I Shimamura K | 1986 | Colloid Polym Sci1986，264，： | 1 |
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