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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | The role of lymph node dissection in the treatment of gallbladder carcinoma显示文摘 | Endo I Togo S | 1997 | Cancer1997，79，： | 1 |
| 3 | Use of transcatheter arterial in fusion of anticancer agents with lipiodol to prevent recurrence of hep atocellular carcinoma after hepatic Tesection显示文摘 | Shimada H Togo S et a | 1999 | Hepatogastroenterol ogy1999，46，26： | 1 |
| 4 | Enhanced tolerance to salt stress and water deficit by over-expressing superoxide dismutase in tobacco(Nicotiana tabacum) chloroplasts 显示文摘 | Badawi G H Yamauchi Y Shimada E | 2004 | Plant Sci2004，166，： | 1 |
| 5 | Beneficial effects of splenectomy on massive hepatectomy model in rats 显示文摘 | Arakawa Y Shimada M Uchiyama H | 2009 | HepatolRes2009，39，4： | 1 |
| 6 | Sacral arachnoid cyst associated with marian syndrome显示文摘 | HOSHINO Y EDAKUNI H SHIMADA H | 2005 | Intern Med2005，44，3： | 1 |
| 7 | Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase显示文摘 | Hasegawa H Shimada M Yonemitsu Y | 2001 | Cancer Gene Ther2001，8，： | 1 |
| 8 | Computer aided operability study显示文摘 | Shimada Y Suzuki K Sayama H | 1996 | Computers & Chemical Engineering1996，20，： | 1 |
| 9 | Lymph node metastasis is associate with allelic loss on chromosome 13q12-13 in esophageal squamous cell carcinoma显示文摘 | Harada H Tanaka H Shimada Y | 1999 | Cancer Res1999，59，9： | 1 |
| 10 | Behavior of axons swchwann cells and perineurial cells in nerve regeneration with in implanted nerve grafts显示文摘 | Wang GY Hirai K Shimada H | 1992 | Brain Res1992，583，12： | 1 |
| 11 | Clinic pathological studies of esophageal carcinoma in achalasia:analyses of carcinogenesis using histological and immunohistochemical procedures 显示文摘 | Chino O Kijima H Shimada H | 2000 | Anticancer REs2000，20，5： | 1 |
| 12 | Initial catalyst deactivition in the hydrotreatment of coal liquid over Ni-Mo and Co-Mo-r-Al2O3 catalysts显示文摘 | Yoshimura Y Shimada H Sato T | 1987 | Applied Catalysis1987，29，1： | 1 |
| 13 | Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity 显示文摘 | Emery DW Sablinski T Shimada H | 1997 | Transplantation1997，64，10： | 1 |
| 14 | Appropriate lymph node dissection for early gastric cancer based on lymph node metastases显示文摘 | Kunisaki C Shimada H Nomura M | 2001 | Surgery2001，129，2： | 1 |
| 15 | Molecular diagnosis of human enteroviruses by phylogeny-based classification by use of the VP4 sequence 显示文摘 | Ishiko H Shimada Y Yonaha M | 2002 | J Infect Dis2002，185，6： | 1 |
| 16 | A complete full-length non- LTR retrotransposon, BMC1, on the W chromosome of the silk- worm,Bombyx mori显示文摘 | Abe H Ohbayashi F Shimada T | 1998 | Genes Genet Syst1998，73，6： | 1 |
| 17 | Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperi- gastric lymph node dissection for early gastric cancer 显示文摘 | Hayashi H Ochiai T Shimada H | 2005 | Surg En- dosc2005，19，9： | 1 |
| 18 | Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver 显示文摘 | KOMATSU T YAMAZAKI H SHIMADA N | 2001 | Clin Cancer Res2001，7，3： | 1 |
| 19 | Surgical outcome after the clearance of abdominal metastatic lymph nodes in 138 patients with thoracic esophageal carcinoma显示文摘 | Shimada H Okazumi S Matsubara H | | 0，，04： | 1 |
| 20 | Post - laminoplasty palsy of upper extremities, with special reference to the spinal cord factors (in Japanese) 显示文摘 | Shimizu T Shimada H Edaknni H | 1996 | Bessatsu Seikeigeka1996，29，： | 1 |
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