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| 1 | Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice显示文摘AIM: To study the relative efficacy of cisapride,metoclopramide, domperidone, erythromycin and mosapride on gastric emptying (GE) and small intestinal transit (SIT)in morphine treated mice.METHODS: Phenol red marker meal was employed to estimate GE and SIT in Swiss albino mice of either sex. The groups included were control, morphine 1 mg/kg (s.c. 15min before test meal) alone or with (45 min before test meal p.o.) cisapride 10 mg/kg, metoclopramide 20 mg/kg,domperidone 20 mg/kg, erythromycin 6 mg/kg and mosapride 20 mg/kg.RESULTS: Cisapride, metoclopramide and mosapride were effective in enhancing gastric emptying significantly (P<0.001)whereas other prokinetic agents failed to do so in normal mice. Metoclopramide completely reversed morphine induced delay in gastric emptying followed by mosapride.Metoclopramide alone was effective when given to normal mice in increasing the SIT. Cisapride, though it did not show any significant effect on SIT in normal mice, was able to reverse morphine induced delay in SIT significantly (P<0.001)followed by metoclopramide and mosapride.CONCLUSION: Metoclopramide and cisapride are most effective in reversing morphine-induced delay in gastric emptying and small intestinal transit in mice respectively. | AD Suchitra SA Dkhar DG Shewade CH Shashindran | 2003 | World Journal of Gastroenterology2003，9，4： | 3 |
| 2 | Single nucleotide polymorphism of CYP3A5*3contributes to clopidogrel resistance in coronary artery disease patients among Tamilian population显示文摘 | PRIYADHARSINI R SHEWADE DG SUBRAJA K | 2014 | Mol Biol Rep2014，41，10： | 1 |
| 3 | Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats显示文摘 | Asad M Shewade DG Koumaravelou K | 2001 | Acta Pharmacol Sin2001，22，6： | 1 |
| 4 | Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population显示文摘 | Krishna Kumar D Shewade DG Loriot MA | 2014 | Eur J Clin Pharmacol2014，70，1： | 1 |
| 5 | Influence of CYP2C9 genetic polymorphism and undernourishment on plasma - free pheny- toin concentrations in epileptic patients 显示文摘 | Ramasamy K Narayan SK Shewade DG | 2010 | Ther Drug Monit2010，32，： | 1 |
| 6 | Gly460Trp polymorphism of the ADD1 gene and essential hypertension in an Indian population: A meta-analysis on hypertension risk 显示文摘 | Ramu P Umamaheswaran G Shewade DG | 2010 | Indian J Hum Genet2010，16，1： | 1 |
| 7 | Influence of CYP2C9 Genetic Polymorphism and Undernourishment on Plasma-Free Phenytoin Concentrations in Epileptic Patients显示文摘 | Ramasamy K Narayan SK Shewade DG | 2010 | Ther Drug Monit2010，32，6： | 1 |
| 8 | Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs显示文摘 | Asad M Shewade DG Koumaravelou K Abraham BK Vasu S Ramaswamy S | 2001 | Life Sci2001，70，1： | 1 |
| 9 | Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs显示文摘 | Shewade DG Koumaravelou K | 2001 | Life Sci2001，70，1： | 1 |
| 10 | Gly460Trp polymor- phism of the ADD1 gene and essential hypertension in an Indian popula- tion : A meta-analysis on hypertension risk 显示文摘 | Ramu P Umamaheswaran G Shewade DG | 2010 | Indian Journal of Hu- man Genetics2010，16，1： | 1 |
| 11 | Gastric antisecretory and antiulcer activty of oxytoncin in rats and guinea pig显示文摘 | Asad M Shewade DG Kounaravelou K | 2001 | Life Sci2001，70，1： | 1 |
| 12 | Candidatcgene polymor- phisms of renin angiotensin system and essential hypertension in a South Indiaz Tamilian population 显示文摘 | Ramu P Umamaheswman G Shewade DG | 2011 | Int J Hum Genet2011，11，： | 1 |
| 13 | Effect of centrally administered oxytocin on gastric and duodenal ulcers in rats 显示文摘 | Asad M Shewade DG Koumaravelou K | 2001 | Acta Pharmacol Sin2001，22，6： | 1 |
| 14 | Gly460Trppolymorphism of the ADD1 gene and essential hypertension in anIndian population:a meta-analysis on hypertension risk显示文摘 | Ramu P Umamaheswaran G Shewade DG | 2010 | IndianJ Human Genet2010，20，16： | 1 |
| 15 | Influence of CYP2C9 genetic polymorphism and undernourishment on plasma- free phenytoin concentrations in epileptic patients显示文摘 | Ramasamy K Narayan SK Shewade DG | 2010 | Ther Drug Monit2010，32，6： | 1 |
| 16 | Influence of CYP2C9 genetic polymorphism and under nourishment on plasma-free phenytoin concentrations in epileptic patients 显示文摘 | Ramasamy K Narayan SK Shewade DG | 2010 | Ther Drug Monit2010，32，6： | 1 |
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