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| 1 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | The coupling loss factors for non-conservatively coupled structures显示文摘The method to calculate the coupling loss factors for non-conservatively coupled structures by using the mobilities of substructures is studied. By using the form of the energy balance equations of conservatively coupled systems, the relationship between the coupling loss factors and the energy ratios in non-conservatively coupled systems is derived. The method to calculate the energy ratios by using the mobilities of substructures is introduced, and experiment verification is carried out. The test data agree well with the predicted results. | SHENG Meiping(Institute of Acoustic Enmneering, Northwestern Polytechnzcal Uniuersity Xi’an 710072)Wang Minqing(Institute of Vibration and Noise Control, Xi ’an Jiaotong University Xi’an’ 710049)SUN Jincai(Institute of Aconstic Engineering, Northwestern P | 1998 | Chinese Journal of Acoustics1998，17，4： | 3 |
| 3 | Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population显示文摘 | Xu RY Ye P Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 4 | Theoretical consideration of optical diffraction from RCA video disc signal显示文摘 | Sheng P | 1978 | RCA Review1978，39，： | 2 |
| 5 | Regulation of matrix metallo-proteinase-9 and inhibition of tumor invasion by the membrane anchored glycoprotein RECK显示文摘 | TAKAHASHI C SHENG Z HORAN T P | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 6 | Characterization of extracellular polymeric substances of aerobic and anaerobic sludge using three- dimensional excitation and emission matrix fluorescence spectroscopy 显示文摘 | Sheng G P Yu H Q | 2006 | Water Research2006，40，6： | 1 |
| 7 | Ruthenium-iron-catalyzed oxidation of an immature asphaltene: Structural features and biomarker distribution显示文摘 | Peng P Fu J Sheng G | 1999 | Energy and Fuel1999，13，2： | 1 |
| 8 | Exercise-induced galanin release facilitated GLUT4translocation in adipocytes of type 2diabetic rats显示文摘 | Lian Y Sheng S Fang P | 2012 | Pharmacol Biochem Behav2012，100，3： | 1 |
| 9 | Analytic model of phononic crystals with local resonances 显示文摘 | Liu Z Y Chan C T Sheng P | 2005 | Physical Review B2005，71，01： | 1 |
| 10 | Low-power CMOS digital design显示文摘 | Cbandrakasan A P Sheng S Brodersen R W | 1992 | IEEE Journal of Solid-state Circuits1992，27，4： | 1 |
| 11 | US Winter Migrants' Park Community Attributes: An Importance Performance Analysis 显示文摘 | Sheng X Simpson P M Siguaw J A | 2014 | Tourism Management2014，，43： | 1 |
| 12 | Degradation and detoxification of acetochlor in soils treated by organic and thiosulfate amendments显示文摘 | Cai X J Sheng G Y Liu W P | 2007 | Chemosphere2007，66，： | 1 |
| 13 | Sorption of lead, copper, cadmium, zinc, and nickel by marine algal biomass: characterization of biosorptive capacity and investigation of mechanisms 显示文摘 | Sheng P Ting Y Chen J | 2004 | J Colloid Interface Sci2004，275，： | 1 |
| 14 | Production,purification, and characterization of recombinant maspin proteins显示文摘 | Sheng S Pemberton P A Sager R | 1994 | J Biol Chem1994，269，30： | 1 |
| 15 | Regulation of matrix metalloproteinase 9 and inhibition of tumor invasion by the membrane anchored glycoprotein RECK显示文摘 | TAKAHASHI C SHENG Z HORAN T P | 1998 | Proc Natl Acad Sci U S A1998，95，： | 1 |
| 16 | Oxy-fuel combustion technology for coalfired power generation 显示文摘 | BUHRE B J P ELLIOIT L K SHENG C D | 2005 | Progress in Energy and Combustion Science2005，31，4： | 1 |
| 17 | Simultaneousestimation of the profiles of the temperature and thescattering albedo in an absorbing,emitting,andisotropically scattering medium by inverse analysis显示文摘 | Zhou H C Yuan P Sheng F | 2000 | International Journal of Heat and Mass Transfer2000，43，23： | 1 |
| 18 | Modeling Micro-inclusion Growth and Separation in Gas-Stirred Ladles 显示文摘 | SHENG Dong-yuan Soder M Jonsson P | 2002 | Scand J Metall2002，31，2： | 1 |
| 19 | Oxy-fuelcombustion technology for coal-fired power genera-tion显示文摘 | Buhre B J P Elliott L K Sheng C D | 2005 | Progress in Energy and Combustion Science2005，31，4： | 1 |
| 20 | Feature-based process planning for environmentally conscious machining-part 1: micrnplanning 显示文摘 | Srinivasan M Sheng P | 1999 | Robotics and Computer-lntegrated Manufacturing1999，15，： | 1 |
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