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| 1 | Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmacological approach显示文摘瞄准:调查在试管内和在活体内治疗学的效果嘘胆道癌症上的一 deacetylase 禁止者 NVP-LAQ824 和 NVP-LBH589。方法:由 NVP-LAQ824 和 NVP-LBH589 的房间生长抑制是在由 MTT 试金的 7 根人的胆道癌症房间线的学习在试管内。另外, NVP-LBH589 的 anti-tumoral 效果在一个妄想的老鼠模型被学习。Anti-tumoral 药机制被为 MIB-1 为 acH4 和 p21 弄污 WAF-1/CIP-1, PARP 试金,房间周期分析, TUNEL 试金,和 immunhistochemistry 的免疫估计。结果:有两混合物的在试管内治疗显著地压制了所有癌症房间线的生长[吝啬的 IC50 ( 3 d ) 0.11 和 0.05 mumol/L ,分别地],并且与 nucleosomal 的 hyperacetylation 被联系嘘一 H4 , p21 WAF-1/CIP-1 的增加的表示, apoptosis ( PARP 劈开)感应,并且房间周期在 G2/M 逮捕检查点。在 28 d 以后, NVP-LBH589 显著地减少了在 66% 集体的肿瘤(胆汁管癌) 并且 87%( 胆囊癌症) 与安慰剂相比的在活体内,并且加强 gemcitabine 的功效。揭示的肿瘤标本的进一步的分析由 TUNEL 试金增加了 apoptosis 并且减少了房间增长(MIB-1 ) 。结论:我们的调查结果建议 NVP-LBH589 和 NVP-LAQ824 对人的胆道癌症是活跃的在试管内。另外, NVP-LBH589 表明了重要在活体内活动并且加强 gemcitabine 的功效。因此,为胆道癌症的治疗的这新药的进一步临床的评估被推荐。 | Thilo Bluethner Manuel Niederhagen Karel Caca Frederik Serr Helmut Witzigmann Christian Moebius Joachim Mossner Marcus Wiedmann | 2007 | World Journal of Gastroenterology2007，13，35： | 5 |
| 2 | Generation of 84-fs pulses from a mode-locked Tm:CNNGG disordered garnet crystal laser显示文摘A mode-locked laser based on a Tm:CNNGG disordered crystal as an active medium and a single-walled carbon nanotube saturable absorber is demonstrated, operating at a central wavelength of 2018 nm. Transformlimited 84 fs pulses are generated with an average output power of 22 mW at a repetition rate of ~90 MHz.A maximum output power of 98 mW is obtained at a slightly longer pulse duration of 114 fs. | ZHONGBEN PAN YICHENG WANG YONGGUANG ZHAO HUALEI YUAN XIAOJUN DAI HUAQIANG CAI JI EUN BAE SUN YOUNG CHOI FABIAN ROTERMUND XAVIER MATEOS JOSEP MARIA SERRES PAVEL LOIKO UWE GRIEBNER VALENTIN PETROV | 2018 | Photonics Research2018，6，8： | 4 |
| 3 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 4 | Biomimetic Autopilot Based on Minimalistic Motion Vision for Navigating along Corridors Comprising U-shaped and S-shaped Turns显示文摘 | Julien R. Serres Franck Ruffier | 2015 | Journal of Bionic Engineering2015，12，1： | 2 |
| 5 | Endograft planning without preoperative arteriography: a clinical feasibility study 显示文摘 | Beebe H Kritpracha B Serres S | 2000 | J Endovasc Surg2000，7，： | 2 |
| 6 | Importance of viral and bacterial infections in chronic obstructive disease eacerbations显示文摘 | De Serres G Lampron N La Forge J | 2009 | Clin Virol2009，46，2： | 1 |
| 7 | Global existence of solutions for the systems of compressible adiabaatic flow through porous media显示文摘 | HSIAO Ling Serre D | 1996 | SIAM J Math Anal1996，27，1： | 1 |
| 8 | Mitochondria genome a rearrangement leads to extension and relocation of the cytochrome C oxidase Subunit I gene in sorghum显示文摘 | Bailey Serres J Hanson D K Fox T D | 1986 | Cell1986，47，： | 1 |
| 9 | Adsorption of elemental mercury on the residual carbon in coal fly ash显示文摘 | SERRE S D SILCOX G D | 2000 | Industrial & Engineering Chemical Resource2000，39，： | 1 |
| 10 | A three-dimensional pseudospectral method for rotating flows in a cylinder显示文摘 | Serre E Pulicani J P | | 0，，： | 1 |
| 11 | A 'combined' levodopa test as a usefulmethod for evaluating the efficacy of dopamine agonists: application to pergolideand bromocriptine显示文摘 | Serre I Marconi R | 1995 | Mov Disord1995，10，5： | 1 |
| 12 | Development of a Cl-impregnated activated carbon for entrained-flow capture of elemental mercury 显示文摘 | Ghorishi S B Keeney R M Serre S D | 2002 | Environmental Science & Technology2002，36，20： | 1 |
| 13 | Antifilaggrin autoanti bodies in early rheumatoid arthritis 显示文摘 | Forslind K Vincent C Serre G | 2000 | Scand J Rheumatol2000，29，5： | 1 |
| 14 | Effects of increased habitat complexity on fish assemblages associated with large artificial reef units (French Mediterranean coast) 显示文摘 | CHARBONNEL E SERRE C RUTTON S | 2002 | ICES Journal of Marine Science2002，59，： | 1 |
| 15 | Evaluation of C4d deposition and circulating antibody in small bowel transplantation显示文摘 | de Serre N P Canioni D Lacaille F | 2008 | Am J Transplant2008，8，6： | 1 |
| 16 | A component-based frame- work for face detection and identification显示文摘 | B Heisele T Serre T Poggio | 2007 | International Journal of Computer Vision2007，74，2： | 1 |
| 17 | Erythrocyte deformability measurement in patients with glaucoma显示文摘 | Mary A Serre I Brun JF | 1993 | J Glaucoma1993，2，： | 1 |
| 18 | Triply bridged dinuclear tris (bipyridine)iron(11) complex: synthesis and electrochemical and structural studies 显示文摘 | Serr B R Andersen K A Elliott C M | 1988 | Inorg Chem1988，27，： | 1 |
| 19 | Kinetics of uptake and metabolism of atrazine in model plant systems显示文摘 | RAVETON M RAVANEL P SERRE A M | 1997 | Pestic Sci1997，49，： | 1 |
| 20 | Use of passive samplers to measure atmospheric ammonia levels in a high-density industrial hog farm area of eastern North Carolina显示文摘 | WILSON S M SERRE M L | | 0，，28： | 1 |
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