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| 1 | First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype显示文摘AIM: To evaluate the effect of first line esomeprazole(EPZ)-based triple therapy on Helicobacter pylori(H. pylori) eradication.METHODS: A total of 80 Japanese patients with gastritis who were diagnosed as positive for H. pylori infection by endoscopic biopsy-based or ^(13)C-urea breath tests were included in this study. The average age of the patients was 57.2 years(male/female, 42/38). These patients were treated by first-line eradication therapy with EPZ 40 mg/d, amoxicillin 1500 mg/d, and clarithromycin 400 mg/d for 7 d. All drugs were given twice per day. Correlations between H. pylori eradication, CYP2C19 genotype, and serum pepsinogen(PG) level were analyzed. This study was registered with the UMIN Clinical Trials Registry(UMIN000009642).RESULTS: The H. pylori eradication rates by EPZbased triple therapy evaluated by intention-to-treat and per protocol were 67.5% and 68.4%, respectively, which were similar to triple therapies with other first-generation proton pump inhibitors(PPIs). The eradication rates in three different CYP2C19 genotypes, described as extensive metabolizer(EM), intermediate metabolizer, and poor metabolizer, were 52.2%, 72.1%, and 84.6%, respectively. The H. pylori eradication rate was significantly lower in EM than non-EM(P < 0.05). The serum PG?Ⅰ?level and PG?Ⅰ/Ⅱ ratio were significantly increased after eradication of H. pylori(P < 0.01), suggesting that gastric atrophy was improved by H. pylori eradication. Thus, first-line eradication by EPZbased triple therapy for patients with H. pylori-positive gastritis was influenced by CYP2C19 genotype, and the eradication rate was on the same level with other firstgeneration PPIs in the Japanese population.CONCLUSION: The results from this study suggest that there is no advantage to EPZ-based triple therapy on H. pylori eradication compared to other firstgeneration PPIs. | Yoshimasa Saito Hiroshi Serizawa Yukako Kato Masaru Nakano Masahiko Nakamura Hidetsugu Saito Hidekazu Suzuki Takanori Kanai | 2015 | World Journal of Gastroenterology2015，21，48： | 13 |
| 2 | ADCP application for long-term monitoring of coastal water显示文摘Three kind of application of ADCP is reported for long-term monitoring in coastal sea.(1)The rourine monitoring of water qualities.The water quality and ADCP echo data (600 kHz) observed in the long-term are analgzed at MT (Marine Tower) Station of Kansai International Airport in the Osaka Bay, Japan. The correlation between the turbidity and echo intensity in the surface layer is not good because air bubbles generated by breaking wave are not detected by the turbidity meter, but detected well by ADCP. When estimating the turbidity consists of plankton population from echo intensity, the effect ofbubbles have to be eliminated. (2) Monitoring stirring up of bottom sediment. The special observation was carded out by using following two ADCP in the Osaka Bay, One ADCP was installed upward on the sea. The other ADCP was hanged downward at the gate type stand about 3 m above from the bottom. At the spring tide, high echo intensities indicating the stirring up of bottom sediment were observed. (3) The monitoring for the boundary condition of water mixing at an estuary. In summer season, the ADCP was set at the mouth of Tanabe Bay in Wakayama Prefecture, Japan.During the observation, water temperature near the bottom showed remarkable falls with interval of about 5~7 d. When the bottom temperature fell, the inflow current with low echo intensity water appears at the bottom layer in the ADCP record. It is concluded that when occasional weak northeast wind makes weak coastal upwelling at the mouth of the bay, the combination of upwelling with internal tidal flow causes remarkable water exchange and dispels the red tide. | YOSHIOKA Hiroshi TAKAYAMA Tomotsuka SERIZAWA Shigeatsu | 2005 | Acta Oceanologica Sinica2005，24，1： | 4 |
| 3 | Three-Dimensional Atom Probe Characterization of Nanoclusters Responsible for Multistep Aging Behavior of an Al-Mg-Si Alloy显示文摘 | A. Serizawa S. Hirosawa T. Sato | 2008 | Metallurgical and Materials Transactions A2008，，2： | 4 |
| 4 | Impact of friction stir welding on recrystallization of oxide dispersion strengthened ferritic steel显示文摘Oxide dispersion strengthened(ODS) steels can be used as the structural materials in the future fusion reactors and the fuel cladding materials in the advanced fission reactors. However, the weldability of ODS steels is a severe problem. In the present study, defect-free joints of the 15Cr-ODS ferritic steel were achieved by friction stir welding at different rotation speeds. The recrystallization, hardness and tensile properties are highly related with the rotation speed of the stir tool. The higher rotation speed results in coarser grains in the top SZ, while the grain size exhibits more complicated relation with the rotation speed in the SZ center. The joint welded at 250 rpm exhibits a maximum tensile strength of 974 MPa that reaches about 84% of that of the base metal. | Wentuo Han Pingping Liu Xiaoou Yi Qian Zhan Farong Wan Kiyohiro Yabuuchi Hisashi Serizawa Akihiko Kimura | 2018 | Journal of Materials Science & Technology2018，34，1： | 4 |
| 5 | Wide-area current differential backup protection employing broadband communications and time transfer systems显示文摘 | Serizawa Y Myoujin M Kitamura K | 1998 | IEEE Trans on Power Delivery1998，13，4： | 2 |
| 6 | Phase I clinical trial of peptide vaccination with URLC10 and VEGFR1epitope peptides in patients with advanced gastric cancer显示文摘 | Yoshie Higashihara Junko Kato Akihito Nagahara Kentaro Izumi Masae Konishi Tomohiro Kodani Nobuko Serizawa Taro Osada Sumio Watanabe | 2014 | International Journal of Oncology2014，，： | 2 |
| 7 | 显示文摘 | Serizawa T Akashi M | 1999 | Chem Mater1999，11，5： | 1 |
| 8 | Simulation study of QoS guaranteed ATM transmission for future power system communication显示文摘 | Doi H Serizawa Y Tode H | 1999 | IEEE Trans onPowerDelivery1999，14，2： | 1 |
| 9 | Optimal trade policy in an international mixed oligopoly 显示文摘 | Serizawa N | 2000 | Seoul Journal of Economics2000，13，1： | 1 |
| 10 | Obstructive sleep apnea is associated with greater thoracic aortic size显示文摘 | Serizawa N Yumino D Takagi A | 2008 | J Am Coll Cardiol2008，52，10： | 1 |
| 11 | Measurement of 2-dimensional local instantaneous liquid film thickness around simulated nuclear fuel rod by uhrasonic transmission technique 显示文摘 | Kamei T Serizawa A | 1998 | Nuclear Engineering and Design1998，184，： | 1 |
| 12 | Capture of HIV-1 gp120 and virions by lectin-immobilized polystyrene nanospheres显示文摘 | Akashi M Niikawa T Serizawa T | 1998 | Bioconjugate Chemistry1998，9，： | 1 |
| 13 | Widearea current differential backup protection employing broadband communications and time transfer systems 显示文摘 | Serizawa Y Myoujin M Kitamura K | 1998 | IEEE Trans on Power Delivery1998，13，4： | 1 |
| 14 | OsHAP3 genes regulate chloroplast biogenesis in rice显示文摘 | Miyoshi K Ito Y Serizawa A | 2003 | The Plant Journal2003，36，4： | 1 |
| 15 | Gamma knife radiosurgery for metastatic brain tumors from lung cancer:a comparison between small cell and non-small cell carcinoma显示文摘 | Serizawa T Ono J Iichi T | | 0，，5： | 1 |
| 16 | X-ray Debye temperature and Grüneisen constant of NpO 2显示文摘 | Hiroyuki Serizawa Yasuo Arai Masahide Takano Yasufumi Suzuki | 1999 | Journal of Alloys and Compounds1999，，1： | 1 |
| 17 | Numerical simul-ation of pear-shaped bead cracking in narrow gap welding显示文摘 | Shibahara M Ito S Serizawa H | 2003 | Transactionsof Joining and Welding Research Institute2003，32，2： | 1 |
| 18 | Representation formulas for integrated semigroups and sine families显示文摘 | Serizawa H | 1992 | Aequationes Math1992，44，23： | 1 |
| 19 | Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B)显示文摘 | Swrizawa N Serizawa S Nakagawa K | 1983 | J Antibiotics1983，36，： | 1 |
| 20 | Radiosurgery for metastatic brain tumors 显示文摘 | Serizawa T | 2009 | Int J Clin Oneol2009，14，： | 1 |
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