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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | Semaglutide降低2型糖尿病患者的心脑血管事件风险显示文摘心血管疾病是2型糖尿病患者发生并发症和死亡的主要原因。最近的一些临床试验报告,一种钠-葡萄糖协同转运蛋白-2抑制剂(依帕列净)和一种胰高血糖素样肽-1(GLP-1)类似物(利拉鲁肽),能够改善心血管高风险的2型糖尿病患者的心血管结局。Semaglutide是GLP-1的一种类似物,半衰期长达约1周,可以一周一次皮下注射,但是尚不清楚其对2型糖尿病患者的心血管效应;由于Semaglutide目前处于开发阶段,尚未被批准用于治疗2型糖尿病。 | Marso SP Bain SC Consoli A 王建中 | 2016 | 中华肾病研究电子杂志2016，5，5： | 141 |
| 3 | Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cells显示文摘AIM: To study the effects of preoperative regional arterychemotherapy (PRACT) in inducing growth inhibition andapoptosis of gastric carcinorna (GC) calls.METHODS: TUNEL ( terminal-deoxynucleotidyl-transferaseTdT-mediated dUTP-fluorescein and labeling) method andimmunohistochemical techniques were used to detect thestate of apoptosis and proliferation of GC cells inhistopathologic sections. A total of 110 cases of GC and 68cases of metastatic lymph node with or without PRACT wereadopted. Correlations between apoptosis index (Al),proliferation index (PI) and PRACT and prognosis wereanalysed.RESULTS: The apoptosis index (Al) was significantly higherin the PRACT group (12.5 ‰ + 4.33‰) than in the untreatedgroup (7. 1‰ + 3. 43 ‰, P < 0. 001 ), whereas theproliferation index (PI) in the PRACT group (33.8 % ± 8.8% ) was eignificantly lower than that in untreated group (43.6 % + 12.8 %, P<0.01). Both Al and PI were correlated tothe differentiation degree of GC in PRACT group, the Al inthe differentiated group was higher than that inundifferentiated group (P<0.001), but the PI was lower inthe differentiated group than that of the undifferentiatedgroup ( P < 0.01 ). The Al of GC cells in metastatic lymphnode was also significantly higher in the PRACT group (7.9‰+ 3.41‰) than in the untreated group (3.6 ‰ + 2.93 ‰,P < 0.01 ), though the PI of GC cells in metastatic lymphnodes in the PRACT group (17. 2 % + 6. 8 % ) wassignificantly lower than that in the untreated group (26.7 %+ 9. 3 %, P < 0. 01 ). The severity of histopathologicchanges was significantly higher in the PRACT group than inthe untreated group ( P < 0.05). In addition, postoperativesurveys demonstrated that the 5-year survival rate of GCpatients in the PRACT group was significantly higher than thatof patients in the untreated group (P<0.01).CONCLUSION: Preoperative regional artery chemotherapy(PRACT) showed inhibitory action on the growth of GC cellsmainly through inhibiting proliferation and inducing theapoptosis of tumor cells. PRACT can improve the prognosisof GC patients also. | Tao, HQ Zou, SC | 2002 | World Journal of Gastroenterology2002，8，3： | 49 |
| 4 | 甘草黄酮类化合物对酪氨酸酶单酚酶的抑制显示文摘研究了甘草中四种黄酮类化合物甘草甙、异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲对酪氨酸酶单酚酶活性的抑制。结果表明异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲的IC50分别为0.072mM,0.038mM,0.0258mM,它们都属于竞争性抑制剂,甘草甙没有抑制活性。研究表明,异甘草素葡萄糖芹菜甙、异甘草甙和甘草查耳酮甲可以作为潜在的美白化妆品添加剂。 | 傅博强 李欢 王小如 LEE Frank SC | 2005 | 天然产物研究与开发2005，17，4： | 38 |
| 5 | 室内氡与肺癌关系研究显示文摘目的 直接调查居室水平氡浓度对居民肺癌危险度的影响 ,并与由矿工受照结果推导的结论相比较。方法 在甘肃省平凉、庆阳两地区进行病例 对照研究。该地区居民稳定而室内氡水平较高。肺癌病例必须是在 1994年 1月至 1998年 4月期间诊断 ,年龄在 30~ 75岁之间 ,居住在平凉和庆阳两地区的居民。根据人口调查资料随机选取对照 ,对照要在年龄、性别、地区方面与病例相匹配。在过去 5~ 30年期间 ,凡住过两年以上的房间都布放了氡探测器。氡测量涵盖了 77%的照射周期。结果 病例居室的平均氡浓度为 2 30 4Bq m3 (n =76 8) ,对照为 2 2 2 2Bq m3 (n =16 5 9)。居民肺癌危险度随室内氡水平的增高有所上升 (P <0 0 0 1)。根据线性模型 ,对全部研究个体而言 ,在 10 0Bq m3 情况下 ,附加比值比 (EOR)为 0 19(95 %CI:0 0 5 ,0 47)。对测量涵盖了 10 0 %照射周期的个体 ,为 0 31(95 %CI:0 10 ,0 81)。在对照射的不确定度进行调整后 ,估算值可增加70 %。结论 研究结果证明室内水平氡照射会增加肺癌危险度 。 | 王作元 Lubin JH 王陇德 张守志 Boice JD Jr 崔宏星 张淑蓉 Conrath SC 夏英 尚兵 Brenner A 雷苏文 Metayer KC 曹吉生 Chen KW 雷淑杰 Kleinerman RA | 2002 | 中华放射医学与防护杂志2002，22，3： | 28 |
| 6 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 7 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger MF Mackay AM Beck SC | | 0，，： | 18 |
| 8 | A clinical and long-term follow-up study of perioperative sequential triple therapy for gastric cancer显示文摘INTRODUCTIONAlthough the long-term postoperative survival rateof gastric cancer(GC) patients has been improvedsignificantly since the local dissection of lymph nodewas widely used in China,yet the low curativeresection rate and the high recurrence rate fromperitoneal and hepatic metastases hinder it fromfurther improvement.To alter the currentunsatisfactory status of GC treatment,a | Zou SC Qiu HS Zhang CW Tao HQ | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 9 | 多发性硬化基于病程的分型(2013版)简介显示文摘1996年,美国全国多发性硬化协会(US National Multiple Sclerosis Society, NMSS)的临床试验建议委员会(Advisory Committee on Clinical Trials in Multiple Sclerosis)根据对多发性硬化(multiple sclerosis,MS)专家的调查问卷确立了MS基于病程的临床分型,旨在明确自然史和人口学研究的亚组定义、促进临床试验受试者的均质化纳入以及在医生和MS患者之间的明确交流,确定了复发缓解型(RRMS)、继发进展型(SPMS)、原发进展型(PPMS)和进展复发型(PRMS)四种类型,并给出了良性和恶性MS的定义。 | Lublin FD Reingold SC Cohen JA 李海峰 | 2014 | 中国神经免疫学和神经病学杂志2014，21，4： | 16 |
| 10 | Proline accumulation in rice seedlings exposed to hydroxyl radical stress in relation to antioxidation显示文摘PROLINE(Pro)is an essential amino acid for proteins and free Pro extensively exists in plants.Pro accumulates in plant cells in response to water stress,salinity,low temperature,air pollu-tants,etc.and has been mainly studied for its role in the osmotic adjustment of plants subject-ed to drought and salinity.In addition to acting as a cytoplasmic osmoticum,Pro | Jiang, MY Guo, SC Zhang, XM | 1997 | Chinese Science Bulletin1997，42，10： | 14 |
| 11 | 共焦显微镜鉴别诊断真菌性角膜炎的实验研究显示文摘目的 研究利用眼科用共焦显微镜鉴别诊断不同真菌性角膜炎的可行性。方法18只新西兰白兔均分为3组,右眼分别接种白色念珠菌、烟曲霉菌和腐皮镰刀菌。接种时,去除角膜中央区5mm直径的上皮,滴新鲜培养的1×107个细胞/ml的白色念珠菌悬浮液,或涂上新鲜培养的烟曲霉菌或腐皮镰刀菌孢子,盖上软性接触镜,行睑裂缝合。在角膜感染后的第5,10和15天时,行共焦显微镜检查、真菌涂片检查和病理切片检查。结果 感染早期(1~5天)炎症反应明显,中期(5~10天)炎症逐渐减轻,10~15天角膜形成疤痕而自愈。烟曲霉菌和腐皮镰刀菌的病程较迁延,反应较白色念珠菌重。共焦显微镜下,感染的白色念珠菌早期主要呈现芽孢状,成高亮度结构,以后发展成具有大量分支的树枝状结构,再发展成链状结构。感染10天后未见任何真菌结构。烟曲霉菌的菌丝在早期则呈较白色念珠菌菌丝粗但分支相对较少的明亮的树枝状结构。中期以后其分支减少并变长,它在角膜组织中保留的时间较白色念珠菌长。在感染早期,腐皮镰刀菌则表现为蚯蚓状结构,以后发展为分支很少的粗短树枝状结构,其分支在3种真菌中最少但直径最粗。真菌涂片和组织学检查的结果与共焦显微镜检查相符。结论 | 李绍伟 Gebhardt BM 史伟云 Beuerman RW Kaufman SC Kaufman HE 谢立信 | 2001 | 眼科研究2001，19，5： | 13 |
| 12 | Chemotherapy of glioblastoma in rats using doxorubicin - loaded nanoparticles显示文摘Glioblastomas belong to the most aggressive human cancers with short survival times.Due to the blood-brainbarrier,they are mostly inaccessible to traditional chemotherapy.We have recently shown that doxorubicin boundto polysorbate-coated nanoparticles crossed the intact blood-brain barrier,thus reaching therapeutic concentra-tions in the brain.Here,we investigated the therapeutic potential of this formulation of doxorubicin in vivo using ananimal model created by implantation of 101/8 glioblastoma tumor in rat brains.Groups of 5-8 glioblastoma- | Steiniger SC Kreuter J Khalansky AS Skidan IN Bobruskin I Smirnova ZS Severin SE Uhl R Kock M Geiger KD Gelperina SE | 2004 | 中国神经肿瘤杂志2004，2，1： | 13 |
| 13 | 湖泊热结构和蒸发的模拟计算显示文摘应用一维涡扩散模型计算一年内不同时期的湖泊垂直温度分布和湖水蒸发率。主管方程是同一水平面内均温的一维非定常热传导方程。模型不要求特定的湖泊拟会参数。模型中涡扩散系数通过Richardson数计算,水面热交换用能量平衡法计算,湖底假定为绝热,主管方程用有限差分法求解。对ColoradoCity湖和Calhoun湖的模拟计算表明:水面温度和温度剖面的计算值与实测值吻合很好,最大差值均在2℃范围内。湖泊年蒸发量的计算值与实测值亦很接近,差值仅为实测值的5%。 | 周从直 Chap.,SC | 1994 | 环境科学1994，15，2： | 12 |
| 14 | Fischer Plots of Wumishan Cyclothems,Precambrian Records of Third-OrderSea-Level Changes显示文摘The Mesoproterozoic Wumishan Formation ((1310 ± 20 ) Ma - (l 207 ± 10) Ma) in Jixian, Tianjin represents a succession of 3 300 meter thick carbonate strata where are the best developed stromatolite biostromes and thrombolite bioherms. These biostromes and bioherms, together with tidal-flat dolomites and muddy dolostones, form Wumishan cyclothems with approximately symmetrical faciessuccession fabrics, which belong to carbonate meter-scale cyclic sequences of peritidal type. These cyclothems are overlain by lagoon dolomitic mudstones and shales and by frequently developed paleosol layers, indicating that the boundary of Wumishan cyclothems is marked by an instantaneously-exposed punctuated surface. Viewed form the regularly vertical stacking patterns of Wumishan cyclothems in long-term sequences, 26 third-order sequences may be discerned in Wumishan Formation. These thirdorder sequences may also be incorporated into six second-order sequences. In order to study the variation range of third-order sea-level changes and the formation period of third-order sequence, 626 cyclothems are discerned in the middle and upper parts of Wumishan Formation where the outcrops are well developed. In terms of the total thickness and the formation period of Mesoproterozoic Wumishan Formation, the crust subsidence rate in the sedimentary period of Wumishan Formation is supposed to be 3 meters at each interval of 100 thousands years. Based on this assumption, Fischer plot might be designed to simulate the third-order sea-level changing pattern. | Mei Mingxiang Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083 Ma Yongsheng China Petrochemical Corporation (SINOPEC), Beijing 100029 Zhou Hongrui Du Benming Luo Zhiqing Guo Qingyin Faculty of Earth Sc | 2001 | Journal of China University of Geosciences2001，12，1： | 11 |
| 15 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 16 | Maize ZmFDR3 localized in chloroplasts is involved in iron transport显示文摘Iron is an essential nutrient for plant metabolism such that Fe-limited plants display chlorosis and suffer from reduced photosynthetic efficiency. Differential display previously identified genes whose expression was elevated in Fe-deficient maize roots. Here,we describe the functional characterization of one of the genes identified in the screen,ZmFDR3 (Zea maize Fe-deficiency-related). Heterologous functional complementation assays using a yeast iron uptake mutant showed that ZmFDR3 functions in iron transport. ZmFDR3 contains a domain found in FliN-proteins of the type III secretion system and is predicted to localize to the thylakoid of plastids. Fluorescence immunocytochemistry showed that ZmFDR3 is localized in the plastids of roots,stems and leaves,with high expression found in guard cell chloroplasts. Transgenic tobacco expressing a 35S-ZmFDR3 construct contains elevated iron content,displays well arranged thylakoid membranes and has photosynthetic indices that are higher than those of the wild type. Together,these results suggest that ZmFDR3 functions in chloroplast iron transport. | HAN JianHui1,SONG XiuFang1,LI Peng1,YANG HuiJun2 & YIN LiPing1 1 College of Life Science,Capital Normal University,Beijing 100048,China 2 Department of Biological Sciences,University of South Carolina,Columbia,SC 29208,USA | 2009 | Science China(Life Sciences)2009，52，9： | 7 |
| 17 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 18 | 异麦芽酮糖醇降低血糖及有益健康的研究动态显示文摘 | 杰弗里.里夫赛(G Livesey B Sc) | 2005 | 中国公共卫生2005，21，3： | 7 |
| 19 | 活性维生素D与慢性肾脏病显示文摘 | Palmer SC 张益民(摘) 李幼姬(校) | 2008 | 中国中西医结合肾病杂志2008，9，5： | 6 |
| 20 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
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