|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | Stem-like cells in bone sarcomas: implications for tumorigenesis显示文摘 | Gibbs C P Kukekov V G Reith J D Tchigrinova O Suslov O N Scott E W | 2005 | Neoplasia2005，7，： | 1 |
| 5 | Improving tourism destination governance:a complexity science approach显示文摘 | Baggio R SCOTT N COOPER C | | 0，，04： | 1 |
| 6 | Destination networks: four Aus- tralian cases 显示文摘 | Scott N Cooper C Baggio R | 2008 | Annals of Tourism Research2008，35，1： | 1 |
| 7 | Network Science: A Review Fo- cused on Tourism 显示文摘 | Baggio R Scott N Cooper C | 2010 | Annals of Tourism Research2010，37，3： | 1 |
| 8 | Widespread ironrich conditions in the mid-Proterozoic ocean显示文摘 | Planavsky N J Mc Goldrick P Scott C T | 2011 | Nature2011，477，： | 1 |
| 9 | Immunity and protection against Brucella abortus 显示文摘 | Golding B Scott DE Scharf 0 Huang LY Zaitseva M Lapham C Eller N Golding H | 2001 | Microbes Infect2001，3，1： | 1 |
| 10 | Use of load control to regulate vohage on distribution networks with embedded generation 显示文摘 | Scott N C Atkinson D J Morrell J E | 2002 | IEEE Trans on Power Systems2002，17，2： | 1 |
| 11 | Destination networks: Four Australian cases 显示文摘 | Scott N Cooper C Baggio R | 2008 | Annals of Tourism Research2008，35，1： | 1 |
| 12 | Network anal- ysis and tourism from theory to practice显示文摘 | SCOTT N BAGGIO R COOPER C | 2008 | Channel View Publication2008，，： | 1 |
| 13 | Single doppler radar observations of a minisupercell tornadic thunderstorm显示文摘 | Westcott N E Scott R W | 1993 | Mon Wea Rev1993，121，6： | 1 |
| 14 | Network science: A review focused on tourism 显示文摘 | Baggio R Scott N Cooper C | 2010 | Annals of Tourism Research2010，37，3： | 1 |
| 15 | Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries显示文摘 | SCOTT N A CIPOLLA G D ROSS C E | 1996 | Circulation1996，93，： | 1 |
| 16 | Use of load control to regulate voltage on distribution networks with embedded generation 显示文摘 | SCOTT N C ATKINSON D J MORRELL J E | 2002 | IEEE Transactions on Power Systems2002，17，2： | 1 |
| 17 | Burden of valvular heart diseases: a population-based study 显示文摘 | Nkomo V T Gardin J M Skelton T N Gottdiener J S Scott C G Enriquez-Sarano M | 2006 | Lancet2006，368，： | 1 |
| 18 | The holey spine: a summary of the history of scientific investigation of the intervertebral foramlna显示文摘 | Cramer GD Scott C Tuck N | 1998 | Chiropr Hist1998，18，2： | 1 |
| 19 | Characteristics and outcomes of patients who achieve high workload (~10 met- abolic equivalents) during treadmill exercise echocardiography 显示文摘 | FINE N M PELLIKKA P A SCOTT C G et a l | 2013 | Mayo Clin Proc2013，88，12： | 1 |
| 20 | Destination networks: Four Australian cases 显示文摘 | Scott N Cooper C Baggio R | 2008 | Annals of Tourism Research2008，35，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员