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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Changes in ABA turnover and sensitivity that accompany dormancy termination of yellow-cedar ( Chamaecyparis nootkatensis ) seeds 显示文摘 | Schmitz N Abrams S R Kermode A R | 2002 | Journal of Experimental Botany2002，53，366： | 1 |
| 3 | Somatostatin enhances insulin stimulated glucose uptake in the perfused human forearm显示文摘 | Moller N Bagger JP Schmitz O | 1995 | J Clin Endocrinol Metab1995，80，6： | 1 |
| 4 | Conventional chemoimmunotherapy(R-CHOEP-14)or high-dose therapy(R-Mega-CHOEP)for young,high-risk patients with aggressive B-cell lymphoma:Final results of the randomized Mega-CHOEP trial of the German High-Grade Non-Hodgkin Lymphoma Study Group(DSHNHL)显示文摘 | Schmitz N Nickelsen M Ziepert M | 2011 | J Clin Oncol2011，29，15： | 1 |
| 5 | Rituximab Purging and/or Maintenance in Patients Undergoing Autologous Transplantation for Relapsed Follicular Lymphoma:a Prospective Randomized Trial From the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation显示文摘 | Pettengell R Schmitz N Gisselbrecht C | | 0，，3： | 1 |
| 6 | Stress, burnout and locus of control in German nurses显示文摘 | SCHMITZ N NEUMANN W OPERMANN R | 2000 | Inter- national Journal of Nursing Studies2000，37，2： | 1 |
| 7 | The pattern of depressivesymptoms in people with type 2 diabetes : A prospective communitystudy 显示文摘 | Schmitz N Gariepy G Smith KJ | 2013 | J Psychosom Res2013，74，2： | 1 |
| 8 | Identification of a Survivin-derived peptide that induces HLA-A0201-restricted antileukemia cytotoxic T lymphocytes显示文摘 | Siegel S Steinmann J Schmitz N | 2004 | Leukemia2004，18，12： | 1 |
| 9 | Diagnosing mental disorders in primary care:The general health questionnaire (GHQ) and the symptom check list (SCL-90-R) as screening instruments显示文摘 | Schmitz N Kruse J Heckrath C | 1999 | Soc Psychiatry Psychiatr Epidemiol1999，34，7： | 1 |
| 10 | Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett's esophagus?A meta-analysis显示文摘 | Coery K E Schmitz S M Shaheen N J | 2003 | Am J Gastroenterol2003，98，11： | 1 |
| 11 | The use of ultrasound and computed tomography for the diagnosis of a squamous cell carcinoma of the oesophago-cardial region of the stomach in a rhesus monkey显示文摘 | Schmitz HC Weishaupt D Borel N | | 0，，01： | 1 |
| 12 | Androgens stimulate gonadotropin-II beta-subunit in eel pituitary cells in vitro 显示文摘 | Huang Y S Schmitz M Le Belle N | 1997 | Molecular and Cellular Endocrinology1997，131，2： | 1 |
| 13 | PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking显示文摘 | Wood CS Schmitz KR Bessman N J | | 0，，： | 1 |
| 14 | Recurrent subthreshold depression in type 2 diabetes: an important risk factor for poor health outcomes 显示文摘 | SCHMITZ N GARIEPY G SMITH K J | 2013 | Diabetes Cam2013，43，6： | 1 |
| 15 | Heat production during different ultrasonic and conventional osteotomy preparations for dental implants显示文摘 | Rashad A Kaiser A Prochnow N Schmitz I Hoffmann E Maurer P | 2011 | Clin Oral Implants Res2011，22，12： | 1 |
| 16 | VSIG4, a B7 family-relatedprotein, is a negative regulator of T cell activation 显示文摘 | Vogt L Schmitz N Kurrer MO | 2006 | J Clin Invest2006，10，116： | 1 |
| 17 | Stress, burnout and locus of control in German nurses 显示文摘 | Schmitz N Neumann W Oppermann R | 2000 | International Journal of Nursing Studies2000，37，2： | 1 |
| 18 | Conventional chemothera- py (CHOEP-14) with rituximab or high-dose chemotherapy (MegaCHOEP) with rituximab for young, high-risk patients with aggressive B-ceU lymphoma: an open-label, randomised, phase 3 trial (DSHNHL 2002-1)显示文摘 | Schmitz N Nickelsen M Ziepert M | 2012 | Lancet Oncol2012，13，12： | 1 |
| 19 | Targets to tackle the pathophysiology of the disease显示文摘 | Schmitz N Kraus VB Aigner T | 2010 | Curr Drug Targets2010，11，5： | 1 |
| 20 | Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection 显示文摘 | Schmitz N Kurrer M Bachmann M F | 2005 | J Virol2005，79，10： | 1 |
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