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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats显示文摘Objective:To study the antioxidant efficacy of Commiphora mukul(C.mukul) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic rats.Methods:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with C.mukul gum resin ethanolic extract(CMEE) for 60 days.The biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.Results:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group.Administration of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.Conclusions:In conclusion,our data indicate the preventive role of C.mukul against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status. | Ramesh B Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi Bhusana Rao B Saralakumari D | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 3 | Linear estimation in Krein spaces part Ⅱ: Applications 显示文摘 | Sayed A H Kailath T | 1996 | IEEE Transactions on Automatic Control1996，41，1： | 1 |
| 4 | Size distributions of small ice pieces calved from icebergs显示文摘 | SAVAGE S B CROCKER G B SAYED M | 2000 | Cold Regions Sci and Technol2000，31，： | 1 |
| 5 | Gravity balancing leg ortho-sis and its performance evaluation 显示文摘 | Sai K B Sunil K A Abbas F | 2006 | IEEE Transactions on Robotics2006，22，6： | 1 |
| 6 | Stress corrosion behavior of α-aluminum bronze in saline water显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 7 | Effect of oxidant treatment of date pit active carbons used as Pd supports in catalytic hydrogenation of nitrobenzene显示文摘 | SAI N B GRANGE P VERHASSELT P | 2005 | App Catal A: Gen2005，286，2： | 1 |
| 8 | Temporary and persistent poverty among ethnic minorities and majority in rural China显示文摘 | Gustafsson B Sai D | 2009 | Review of Income and Wealth2009，55，1： | 1 |
| 9 | Villages where China's ethnic minorities live显示文摘 | Gustafsson B Sai D | 2009 | China Economic Review2009，20，2： | 1 |
| 10 | Linear Estimation in Krein Spaces - Part Ⅱ: Application显示文摘 | Hassibi B Sayed A H Kailath T | 1996 | IEEE Transactions on Automatic Control1996，41，1： | 1 |
| 11 | Linear estimation in Krein spaces: part: I : theory 显示文摘 | HASSIBI B SAYED A H KAILATH T | 1996 | IEEE Transactions on Automatic Control1996，，1： | 1 |
| 12 | Stress developed by cohesion less granularmaterials sheared in an annular shear shell显示文摘 | SAVAGE S B SAYED M | 1984 | Journal of Fluid Mechanics1984，142，： | 1 |
| 13 | Linear estimation in Krein spaces: part I1 : applications 显示文摘 | HASSIBI B SAYED A H KAILATH T | 1996 | IEEE Transactions on Automatic Control1996，，1： | 1 |
| 14 | Brick-ballast and recycled-aggregate concrete显示文摘 | Kumar V Roy B N Sai A S R | 1988 | Indian Concrete Journal1988，62，： | 1 |
| 15 | Robust adaptive variable structure control of spacecraft under control input saturation 显示文摘 | Jovan D B Sai Ming Li Mehra K | 2001 | Journal of Guidance Control and Dynamics (S0731-5090)2001，24，1： | 1 |
| 16 | Stress corrosion behavior of α-aluminum bronze in saline water 显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 17 | Purification, Sequencing, and Biochemical Characterization of a Novel Calcium- Indep- endent Ci - Amylase AmyTVE from Thermoactinomyces vulgaris显示文摘 | El- Sayed A K A Dobara M I B El- Fallal A A | 2013 | Applied Biochemistry and Biotechnology2013，170，3： | 1 |
| 18 | Brick-ballast and recycled-aggregate concrete显示文摘 | Kumar V Roy B N Sai A S R | 1988 | Indian Concrete Journal1988，62，： | 1 |
| 19 | Stresses developed by dry cohesiordess granular materials sheared in an annular shear cell显示文摘 | Savage S B Sayed M | 1984 | Journal of Fluid Mechanics1984，142，： | 1 |
| 20 | The effects of a hydrogel polymer on the growth of certain horticultural crops under saline conditions显示文摘 | EL SAYED H KIRKWOOD R C GRAHAM N B | 1991 | J Expt Bot1991，42，： | 1 |
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