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| 1 | Diagnosis of Helicobacter pylori : What should be the gold standard?显示文摘Since the discovery of Helicobacter pylori(H. pylori) in 1983, numerous detection methods for the presence of the bacterium have been developed. Each one of them has been associated with advantages and disadvantages. Noninvasive tests such as serology, 13 C urea breath test(UBT) and stool antigen tests are usually preferred by the clinicians. Serology has its own limitation especially in endemic areas while 13 C UBT is technically very demanding. The stool antigen detection method, although specific, is usually associated with poor sensitivity. The 13 C UBT is believed to be specific, but with present revelation of the fact that stomach is colonized by many other urease producing bacteria makes it questionable. Histology, culture, rapid urease test and polymerase chain reaction(PCR) are the tests which are carried out on antral biopsies collected by invasive means. Histology has been proposed to be very sensitive and specific but the question is how by simply looking the morphology of the bacteria in the microscope, one can claim that the curved bacterium is exclusively H. pylori. Rapid urease test(RUT), the doctor's test, is also challenged because the presence of other urease producing bacteria in the stomach cannot be denied. Moreover, RUT has been reported with poor sensitivity specially, when density of the bacterium is low. Isolation of H. pylori is essential to investigate its growth requirements, antibiotic susceptibility testing, studying virulence factor to develop vaccine and many more explorations. It has also got several disadvantages i.e., special condition for transporting, media, incubation and few days waiting for the colonies to appear, apart from the speed essentially needed to process the specimens. Till date, majority of the microbiological laboratories in the world are not equipped and trained to isolate such fastidious bacterium. The option left is PCR methods to detect H. pylori 's DNA in gastric mucosa, gastric juice, saliva, dental plaques and environmental specimens. There are speculations for false positivity due to detection of non-pylori Helicobacters due to genetic sharing; and false negativity due to low bacterial counts and presence of PCR inhibitors. However, specimen collection, transportation and processing do not require speed and special conditions. PCR based diagnosis may be considered as gold standard by designing primers extremely specific to H. pylori and targeting at least more than one conserved genes. Similarly specificity of PCR may be improved by use of internal Primers. Further, nested PCR will take care of false negatives by countering the effect of PCR inhibitors and low bacterial counts. Therefore, nested PCR based methods if performed properly, may be proposed as gold standard test. | Saurabh Kumar Patel Chandra Bhan Pratap Ashok Kumar Jain Anil Kumar Gulati Gopal Nath | 2014 | World Journal of Gastroenterology2014，20，36： | 30 |
| 2 | Outcome of open reduction and internal fixation of intraarticular calcaneal fracture fixed with locking cal- caneal plate显示文摘ObjectiveDebate 关于跟骨的破裂的管理继续,在开的减小和内部固定和关上的治疗之间。因此,我们瞄准在与锁跟骨的 plate.MethodsIn 修理的跟骨的破裂的代替的联合消沉类型评估开的减小和内部固定的放射学、功能的结果这个系列, 28 个病人( 26 单方并且 2 双边)与跟骨的破裂的联合消沉类型,作为每 Essex-Lopresti ,分类系统与在 3 星期损害以内锁跟骨的板被操作。病人们以 anteroposterior 的联系损害和 X 光被评估, calcaneum 的侧面、轴的看法。CT 扫描被做估计粉碎和关节的消沉的数量。病人们被跟随在上面临床上并且放射学地至少为 1 年。放射学的评价被 Bohler’s 角度和 Gissane’s 角度与跟骨的高度和宽度的测量一起做。功能的结果用 14.5 个月的美国 Orthopaedics 英尺和脚关节社会( AOFAS ) scale.ResultsAt 一般水准后续被估计,平均 AOFAS 分数是 86.3 (范围 66~97 ),与86%有对好结果优秀并且 2 (7.7%)并且 1 (3.7%)分别地有公平、差的结果。所有病人让稳定的脚关节与所有有的背屈和脚底的屈曲连接超过 30 °
。运动的平均 subtalar 范围是 17 °
。吝啬的 Bohler’s 角度,吝啬的 Gissane’s 角度,跟骨的高度和宽度是 25.47 °
, 121.3 °
, 4.32 厘米和 3.81 厘米分别地在最后的后续。三个病人在切口地点有拍动坏死,一个人有表面、深的感染。Subtalar 关节炎在 5 个病人被看见,而在 1 个病人的小腿腹的神经 hypoaesthesia。任何一个都没病人有分隔空间症候群,脚跟垫问题,小腿侧的 tendinitis,反射同情的 dystropy 或与锁住植入 failure.ConclusionOpen 减小和内部固定跟骨的板给声音功能的结果,即解剖地恢复高度,宽度, Bohler’s 和 calcaneum 的 Gissiane’s 角度的重建,并且允许早动员。 | Saurabh Jain Anti Kumar Jain Ish Kumar | 2013 | Chinese Journal of Traumatology2013，16，6： | 25 |
| 3 | Critical review of EPS production, synthesis and composition for sludge flocculation显示文摘Extracellular polymeric substances(EPS) produced by microorganisms represent biological macromolecules with unfathomable potentials and they are required to be explored further for their potential application as a bioflocculant in various wastewater sludge treatment. Although several studies already exist on biosynthetic pathways of different classical biopolymers like alginate and xanthan, no dedicated studies are available for EPS in sludge. This review highlights the EPS composition, functionality, and biodegradability for its potential use as a carbon source for production of other metabolites. Furthermore, the effect of various extraction methods(physical and chemical) on compositional, structural, physical and functional properties of microbial EPS has been addressed. The vital knowledge of the effect of extraction method on various important attributes of EPS can help to choose the suitable extraction method depending upon the intended use of EPS. The possible use of different molecular biological techniques for enhanced production of desired EPS was summarized. | Klai Nouha Ram Saurabh Kumar Sellamuthu Balasubramanian Rajeshwar Dayal Tyagi | 2018 | Journal of Environmental Sciences2018，30，4： | 19 |
| 4 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 5 | MR纵向弛豫时间定量成像评价肥厚型心肌病心肌纤维化的初步研究显示文摘目的探讨纵向弛豫时间定量(T1 mapping)成像对肥厚型心肌病(HCM)纤维化的诊断价值。方法按诊断标准人选48例HCM患者和18名健康志愿者,分别行常规延迟强化(LGE)检查与T1 mapping成像,按HCMLGE有无及程度,分为LGE远处正常区、LGE边缘区、LGE区(分为晕状LGE与典型斑片状LGE),分别测量2组心肌对比剂增强后T.值的变化率并进行卡方检验、两两对比及ROC曲线分析。结果健康志愿者T1值变化率与HCM远离LGE区差异无统计学意义(3.98±3.19和3.36±2.77.t=0.98,P〉0.05),与LGE周边区(13.51±5.67)、晕状区(17.70±5.57)、斑片区(36.62±8.03)比较差异有统计学意义(t值分别为15.28、17.13和47.48,P值均〈0.01);远处正常区(3.36±2.77)与LGE周边区、晕状区及斑片区比较差异均有统计学意义(t值分别为19.64、20.76和56.64,P值均〈0.01);LGE周边区与LGE晕状区和斑片区比较差异均有统计学意义(t值分别为6.12和39.90,P值均〈0.01);LGE晕状区与斑片区比较差异有统计学意义(t=25.63,P〈0.01)。ROC曲线提示T1 mapping成像较传统LGE成像有更大的曲线下面积(0.974±0.050和0.751±0.180)。结论HCM纤维化常见,且受累心肌的纤维化程度不一,T1mapping成像能对HCM患者心肌纤维化的严重程度进行评价,能够发现处于纤维化早期的病变。 | 陆敏杰 赵世华 蒋世良 尹刚 赵涛 张岩 凌坚 韦云青 刘琼 陈秀玉 马宁 相里伟 殷小荣 安靖 Renate Jerecic Shah Saurabh Xue Hui | 2013 | 中华放射学杂志2013，47，5： | 14 |
| 6 | A global,high-resolution(30-m)inland water body dataset for 2000:first results of a topographic-spectral classification algorithm显示文摘The science and management of terrestrial ecosystems require accurate,high-resolution mapping of surface water.We produced a global,30-m-resolution inland surface water dataset with an automated algorithm using Landsat-based surface reflectance estimates,multispectral water and vegetation indices,terrain metrics,and prior coarse-resolution water masks.The dataset identified 3,650,723 km2 of inland water globally–nearly three quarters of which was located in North America(40.65%)and Asia(32.77%),followed by Europe(9.64%),Africa(8.47%),South America(6.91%),and Oceania(1.57%).Boreal forests contained the largest portion of terrestrial surface water(25.03%of the global total),followed by the nominal‘inland water’biome(16.36%),tundra(15.67%),and temperate broadleaf and mixed forests(13.91%).Agreement with respect to the Moderate-resolution Imaging Spectroradiometer water mask and Landsat-based national land-cover datasets was very high,with commission errors<4%and omission errors<14%relative to each.Most of these were accounted for in the seasonality of water cover,snow and ice,and clouds–effects which were compounded by differences in image acquisition date relative to reference datasets.The Global Land Cover Facility(GLCF)inland surface water dataset is available for open access at the GLCF website(http://gffzzc4da8a9a1d6d4c7ahbwxcxnnw696c6un5.ffgz.tsg.suse.edu.cn). | Min Feng Joseph O.Sexton Saurabh Channan John R.Townshend | 2016 | International Journal of Digital Earth2016，9，2： | 13 |
| 7 | Newer perspectives of coronary artery disease in young显示文摘Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young CAD.Recent studies show a prevalence of 1.2% of CAD cases in this age group.Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD subjects.But the prevalence of these risk factors seems to vary in younger subjects.By far the most commonly associated risk factor is smoking in young CAD.Several genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo B.Biomarkers such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer studies.In general CAD in young has better prognosis than older subjects.In terms of prognosis two risk factors obesity and current smoking are associated with poorer outcomes.Angiographic studies shows predominance of single vessel disease in young CAD patients.Like CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events. | Amitesh Aggarwal Saurabh Srivastava M Velmurugan | 2016 | World Journal of Cardiology2016，8，12： | 13 |
| 8 | Comparison of phenotypic markers and neural differentiation potential of multipotent adult progenitor cells and mesenchymal stem cells显示文摘AIM: To compare the phenotypic and neural differentiation potential of human bone marrow derived multipotent adult progenitor cells (MAPC) and mesenchymal stem cells (MSC). METHODS: Cultures of MAPC and MSC were established in parallel from same samples of human bone marrow (n = 5). Both stem cell types were evaluated for expression of pluripotency markers including Oct-4 and Nanog by immunocytochemistry and reversetranscription polymerase chain reaction (RT-PCR) and expression of standard mesenchymal markers including CD14, CD34, CD44, CD45, CD73, CD90, CD105 andhuman leukocyte antigen (HLA)-ABC by flow cytometry. After treatment with neural induction medium both MAPC and MSC were evaluated for expression of neural proteins [neuronal filament-200 (NF-200) and glial fibrillar acidic protein (GFAP)] by immunocytochemistry and Western blotting and neural genes [NF-200, GFAP, Tau, microtubule-associated protein (MAP)-1B, MAP-2, neuron-specific enolase (NSE) and oligodendrocyte-1 (Olig-1)] by quantitative real-time-PCR. RESULTS: MAPC had small trigonal shaped while MSC had elongated spindle-shaped morphology. The MAPC expressed Oct-4 and Nanog both at gene and protein levels, whereas MSC were negative for these pluripotent markers. MAPC were negative for HLA-ABC while MSC had high expression of HLA-ABC. In addition, MAPC as compared to MSC had significantly lower expression of CD44 (36.56% ± 1.92% vs 98.23% ± 0.51%), CD73 (15.11% ± 2.24% vs 98.53% ± 2.22%) and CD105 (13.81% ± 3.82%vs 95.12% ± 5.65%) (P < 0.001, for all) MAPC cultures compared to MSC cultures treated with neural induction medium had significantly higher fold change expression of NF-200 (0.64), GFAP (0.52), Tau (0.59), MAP-2 (0.72), Olig-1 (0.18) and NSE (0.29) proteins (P < 0.01 for Olig-1 and P < 0.001 for rest) as well as higher fold change expression of genes of NF-200 (1.34),GFAP (1.12),Tau (1.08),MAP-1B (0.92), MAP-2 (1.14) andNSE (0.4) (P < 0.001 for all). CONCLUSION: MAPC can be differentially characterized from MSC as Oct-4 and Nanog positive stem cells with no expression of HLA-ABC and low expression of mesenchymal markers CD44, CD73 and CD105 and when compared to MSC they possess greater predilection for differentiation into neuro-ectodermal lineage. | Saurabh Pratap Singh Naresh Kumar Tripathy Soniya Nityanand | 2013 | World Journal of Stem Cells2013，5，2： | 10 |
| 9 | Centralized multi-agent implementation for securing critical loads in PV based microgrid显示文摘The promotion of recent critical load securing of power system research has been directed towards centralized commands and control functions.This paper presents a multi-agent based critical load securing in a PV based microgrid.For the trustworthy operation of critical buildings,the reliability,efficiency and security of the power system should be guaranteed.At present,to increase the security and reliability of electricity supply there is a need to design a distributed and autonomous subset of a larger grid or a microgrid.This work also clearly discusses the modelling and simulation of specialized microgrid called an Intelligent Distributed Autonomous Power Systems(IDAPS).The IDAPS microgrid plays a crucial role in constructing power grid that facilitate use of renewable energy technologies.IDAPS microgrid comprising of solar photovoltaic as distributed energy resources,different loads and their control algorithms,has been developed.Several case studies have been simulated to evaluate the operation of the IDAPS microgrid during parallel,islanded mode operation and securing critical loads during emergency. | A.SUJIL Saurabh Kumar AGARWAL Rajesh KUMAR | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，1： | 10 |
| 10 | Global characterization and monitoring of forest cover using Landsat data: opportunities and challenges显示文摘The compilation of global Landsat data-sets and the ever-lowering costs of computing now make it feasible to monitor the Earth’s land cover at Landsat resolutions of 30 m.In this article,we describe the methods to create global products of forest cover and cover change at Landsat resolutions.Nevertheless,there are many challenges in ensuring the creation of high-quality products.And we propose various ways in which the challenges can be overcome.Among the challenges are the need for atmospheric correction,incorrect calibration coefficients in some of the data-sets,the different phenologies between compila-tions,the need for terrain correction,the lack of consistent reference data for training and accuracy assessment,and the need for highly automated character-ization and change detection.We propose and evaluate the creation and use of surface reflectance products,improved selection of scenes to reduce phenological differences,terrain illumination correction,automated training selection,and the use of information extraction procedures robust to errors in training data along with several other issues.At several stages we use Moderate Resolution Spectro-radiometer data and products to assist our analysis.A global working prototype product of forest cover and forest cover change is included. | John R.Townshend Jeffrey G.Masek Chengquan Huang Eric.F.Vermote Feng Gao Saurabh Channan Joseph O.Sexton Min Feng Raghuram Narasimhan Dohyung Kim Kuan Song Danxia Song Xiao-Peng Song Praveen Noojipady Bin Tan Matthew C.Hansen Mengxue Li Robert E.Wolfe | 2012 | International Journal of Digital Earth2012，5，5： | 10 |
| 11 | Chronic hepatitis E: A brief review显示文摘Hepatitis E viral infection has traditionally been considered an acute, self-limited, water borne disease similar to hepatitis A, endemic to developing countries. However, over the past decade, zoonotic transmission and progression to chronicity in human patients has been identified, resulting in persistently elevated transaminase levels, progressive liver injury and cirrhosis. In addition to liver injury, neurological, renal and rheumatological manifestations have also been reported. Chronic hepatitis E occurs mainly in immunosuppressed individuals such as transplant recipients, human immunodeficiency virus patients with low CD4 counts and in patients with hematological malignancies receiving chemotherapy. Diagnosis is established by persistent elevation of hepatitis E virus RNA in the stool or serum. This population often requires treatment with antiviral agents, particularly ribavirin, as spontaneous clearance with reduction in immunosuppression occurs only in about a third of the patients. The purpose of this review, is to further discuss the clinical presentation, and recent advances in diagnosis, treatment and prophylaxis of chronic hepatitis E. | Arvind R Murali Vikram Kotwal Saurabh Chawla | 2015 | World Journal of Hepatology2015，7，19： | 9 |
| 12 | Portal hypertensive enteropathy显示文摘Portal hypertensive enteropathy(PHE) is a condition that describes the pathologic changes and mucosal abnormalities observed in the small intestine of patients with portal hypertension. This entity is being increasingly recognized and better understood over the past decade due to increased accessibility of the small intestine made possible by the introduction of video capsule endoscopy and deep enteroscopy. Though challenged by its diverse endoscopic appearance, multiple scoring systems have been proposed to classify the endoscopic presentationand grade its severity. Endoscopic findings can be broadly categorized into vascular and non-vascular lesions with many subtypes of both categories. Clinical manifestations of PHE can range from asymptomatic incidental findings to fatal gastrointestinal hemorrhage. Classic endoscopic findings in the setting of portal hypertension may lead to a prompt diagnosis. Occasionally histopathology and cross sectional imaging like computed tomography or magnetic resonance imaging may be helpful in establishing a diagnosis. Management of overt bleeding requires multidisciplinary approach involving hepatologists, endoscopists, surgeons, and interventional radiologists. Adequate resuscitation, reduction of portal pressure, and endoscopic therapeutic intervention remain the main principles of the initial treatment. This article reviews the existing evidence on PHE with emphasis on its classification, diagnosis, clinical manifestations, endoscopic appearance, pathological findings, and clinical management. A new schematic management of ectopic variceal bleed is also proposed. | Parit Mekaroonkamol Robert Cohen Saurabh Chawla | 2015 | World Journal of Hepatology2015，7，2： | 8 |
| 13 | RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway显示文摘天生的有免疫力的反应是主人防卫的第一根线消除病毒的感染。在 cytosol 的模式识别受体例如 RIG-I-like 受体( RLR )和像点头的受体( NLR ),并且如同受体( TLR )检测病毒的感染并且开始抗病毒的基因的一个队的抄写,膜绑了使用费,包括干扰素( IFN )和干扰素刺激了基因( ISG ),它最终堵住病毒的复制。减少病毒的传播的另一机制通过 RIPA, apoptosis 的导致 RLR 的调停 IRF3 的小径,哪个原因经历早熟的死亡的感染的房间。抄写因素 IRF3 能调停由两个都导致抗病毒的基因并且通过 RIPA 的激活触发 apoptosis 的细胞的抗病毒的回答。在 RIPA 的 IRF3 激活的机制从 transcriptional 激活的是不同的;它要求 IRF3 的特定的离氨酸残余的线性 polyubiquitination。用 RIPA 活跃,却 transcriptionally 不活跃, IRF3 异种,它被看那 RIPA 能在老鼠阻止病毒的复制和致病。 | Saurabh Chattopadhyay Ganes C. Sen | 2017 | Protein & Cell2017，8，3： | 7 |
| 14 | Viral degradasome hijacks mitochondria to suppress innate immunity显示文摘在主人和病原体的能力的天生的免疫之间的平衡影响致病和毒力强烈躲避它。二 nonstructural (NS ) 蛋白质, NS1 和 NS2,呼吸 syncytial,病毒(RSV ) 极其为 RSV 被要求毒力。一起,他们强烈压制类型我干扰素(IFN ) 调停了由降级或禁止多重细胞的因素的主人房间的天生的免疫为 IFN 正式就职或反应要求了小径包括 RIG-I, IRF3, IRF7, TBK1 和 STAT2。这里,我们为 NS 蛋白质装配的大、异构的 degradative 建筑群的存在提供证据,我们把它称为 “ NS-degradasome”(NSD ) 。NSD 是粗略地,在尺寸的 ~ 300-750 kD,和它的 degradative 活动被净化的线粒体的增加在 vitro 提高。在房间, NS 蛋白质的多数和到在 RSV 感染之上的线粒体的 NSD translocated 的底层内。基因并且药理学证据证明天生的豁免的最佳的抑制要求 mitochondrial MAVS 和 mitochondrial 活动性。一起,我们建议在的一个新奇范例线粒体,知道为主人的天生的有免疫力的激活重要,为天生的免疫的病毒的抑制也是重要的。 | Ramansu Goswami Tanmay Majumdar Jayeeta Dhar Saurabh Chattopadhya3~ Sudip K Bandyopadhyay Valentina Verbovetskaya Ganes C Sen Sailen Barik | 2013 | Cell Research2013，23，8： | 6 |
| 15 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 16 | Global, 30-m resolution continuous fields of tree cover: Landsat-based rescaling of MODIS vegetation continuous fields with lidar-based estimates of error显示文摘We developed a global,30-m resolution dataset of percent tree cover by rescaling the 250-m MOderate-resolution Imaging Spectroradiometer(MODIS)Vegetation Continuous Fields(VCF)Tree Cover layer using circa-2000 and 2005 Landsat images,incorporating the MODIS Cropland Layer to improve accuracy in agricultural areas.Resulting Landsat-based estimates maintained consistency with the MODIS VCF in both epochs(RMSE=8.6%in 2000 and 11.9%in 2005),but showed improved accuracy in agricultural areas and increased discrimination of small forest patches.Against lidar measurements,the Landsat-based estimates exhibited accuracy slightly less than that of the MODIS VCF(RMSE=16.8%for MODIS-based vs.17.4%for Landsat-based estimates),but RMSE of Landsat estimates was 3.3 percentage points lower than that of the MODIS data in an agricultural region.The Landsat data retained the saturation artifact of the MODIS VCF at greater than or equal to 80%tree cover but showed greater potential for removal of errors through calibration to lidar,with post-calibration RMSE of 9.4%compared to 13.5%in MODIS estimates.Provided for free download at the Global Land Cover Facility(GLCF)website(www.landcover.org),the 30-m resolution GLCF tree cover dataset is the highest-resolution multi=temporal depiction of Earth’s tree cover available to the Earth science community. | Joseph O.Sexton Xiao-Peng Song Min Feng Praveen Noojipady Anupam Anand Chengquan Huang Do-Hyung Kim Kathrine M.Collins Saurabh Channan Charlene DiMiceli John R.Townshend | 2013 | International Journal of Digital Earth2013，6，5： | 5 |
| 17 | Pyogenic liver abscess caused by Fusobacterium in a 21-year-old immunocompetent male显示文摘A 21-year-old male with no significant past medical history, presented with right upper quadrant(RUQ) abdominal pain along with fevers and chills. Lab work revealed leukocytosis, anemia, and slightly elevated alkaline phosphatase. Viral serology for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus were negative and he was immunocompetent.Computed tomography imaging revealed hepatic abscesses, the largest measuring 9.5 cm. Empiric antibiotics were started and percutaneous drains were placed in the abscesses. Anaerobic cultures from the abscesses grew Fusobacterium nucleatum. This is a gram negative anaerobic bacteria; a normal flora of the oral cavity. Fusobacterium is most commonly seen in Lemiere's disease, which is translocation of oral bacteria to the internal jugular vein causing a thrombophlebitis and subsequent spread of abscesses. Our patient did not have Lemiere's, and is the first case described of fusobacterium pyogenic liver abscess in a young immunocompetent male with good oral hygiene. This case was complicated by sepsis, empyema, and subsequent abscesses located outside the liver. These abscesses' have the propensity to flare abruptly and can be fatal. This case not only illustrates fusobacterium as a rare entity for pyogenic liver abscess, but also the need for urgent diagnosis and treatment. It is incumbent on physicians to diagnose and drain any suspicious hepatic lesions. While uncommon, such infections may develop without any overt source and can progress rapidly. Prompt drainage with antibiotic therapy remains the cornerstone of therapy. | Zohair Ahmed Saurabh K Bansal Sonu Dhillon | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 18 | Neglected isolated fracture of the trochlea humeri显示文摘 | Ajay Pal Singh Ish Kumar Dhammi Anil Kumar Jain Saurabh Jain | 2010 | Chinese Journal of Traumatology2010，13，4： | 4 |
| 19 | Pseudomonas fluorescens-like bacteria from the stomach:A microbiological and molecular study显示文摘AIM:To characterize oxidase-and urease-producing bacterial isolates,grown aerobically,that originated from antral biopsies of patients suffering from acid peptic diseases.METHODS:A total of 258 antral biopsy specimens were subjected to isolation of bacteria followed by tests for oxidase and urease production,acid tolerance and aerobic growth.The selected isolates were further characterized by molecular techniques viz.amplifications for 16S rRNA using universal eubacterial and HSP60 gene specific primers.The amplicons were subjected to restriction analysis and partial sequencing.A phylogenetic tree was generated using unweighted pair group method with arithmetic mean(UPGMA) from evolutionary distance computed with bootstrap test of phylogeny.Assessment of acidity tolerance of bacteria isolated from antrum was performed using hydrochloric acid from 10-7 mol/L to 10-1 mol/L.RESULTS:Of the 258 antral biopsy specimens collected from patients,179(69.4%) were positive for urease production by rapid urease test and 31%(80/258) yielded typical Helicobacter pylori(H.pylori) after 5-7 d of incubation under a microaerophilic environment.A total of 240(93%) antral biopsies yielded homogeneous semi-translucent and small colonies after overnight incubation.The partial 16S rRNA sequences revealed that the isolates had 99% similarity with Pseudomonas species.A phylogenetic tree on the basis of 16S rRNA sequences denoted that JQ927226 and JQ927227 were likely to be related to Pseudomonas fluorescens(P.fluorescens).On the basis ofHSP60 sequences applied to the UPGMA phylogenetic tree,it was observed that isolated strains in an aerobic environment were likely to be P.fluorescens,and HSP60 sequences had more discriminatory potential rather than 16S rRNA sequences.Interestingly,this bacterium was acid tolerant for hours at low pH.Further,a total of 250(96.9%) genomic DNA samples of 258 biopsy specimens and DNA from 240 bacterial isolates were positive for the 613 bp amplicons by targeting P.fluorescens-specific conserved putative outer membrane protein gene sequences.CONCLUSION:This study indicates that bacterial isolates from antral biopsies grown aerobically were P.fluorescens,and thus acid-tolerant bacteria other than H.pylori can also colonize the stomach and may be implicated in pathogenesis/protection. | Saurabh Kumar Patel Chandra Bhan Pratap Ajay Kumar Verma Ashok Kumar Jain Vinod Kumar Dixit Gopal Nath | 2013 | World Journal of Gastroenterology2013，19，7： | 4 |
| 20 | Endoscopic ultrasound-guided vascular interventions: Current insights and emerging techniques显示文摘Endoscopic ultrasound(EUS)is one of the significant breakthroughs in the field of advanced endoscopy.In the last two decades,EUS has evolved from a diagnostic tool to a real-time therapeutic modality.The luminal gastrointestinal(GI)tract provides a unique opportunity to access multiple vascular structures,especially in the mediastinum and abdomen,thus permitting a variety of EUS-guided vascular interventions.The addition of the doppler and contrast-enhanced capability to EUS has further helped provide real-time visualization of blood flow in vessels through the GI tract.EUS-guided vascular interventions rely on standard endoscopic accessories and interventional tools such as fine-needle aspiration needles and fine-needle biopsy.EUS allows the visualization of various structures in real-time by differentiating tissue densities and vascularity,thus,avoiding radiation exposure.EUS-guided techniques also allow real-time microscopic examination after target biopsy.Furthermore,many necessary interventions can be done during the same procedure after diagnosis.This article provides an overview of EUS-guided vascular interventions such as variceal,non-variceal bleeding interventions,EUSguided portal vein(PV)access with the formation of an intrahepatic portosystemic shunt,and techniques related to diagnosis of GI malignancies.Furthermore,we discuss current insights and future outlook of therapeutic modalities like PV embolization,PV sampling,angiography,drug administration,and portal pressure measurement. | Rupinder Mann Hemant Goyal Abhilash Perisetti Saurabh Chandan Sumant Inamdar Benjamin Tharian | 2021 | World Journal of Gastroenterology2021，27，40： | 4 |
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